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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
The red circled blue spheres are used for the predicted targets.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB02141


17 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa04915 Estrogen signaling pathway Organismal Systems Endocrine system NOS3 1 0.14 0.026
2 hsa05418 Fluid shear stress and atherosclerosis Human Diseases Cardiovascular diseases NOS3 1 0.14 0.026
3 hsa04921 Oxytocin signaling pathway Organismal Systems Endocrine system NOS3 1 0.14 0.026
4 hsa04022 cGMP-PKG signaling pathway Environmental Information Processing Signal transduction NOS3 1 0.14 0.026
5 hsa04020 Calcium signaling pathway Environmental Information Processing Signal transduction NOS3 1 0.19 0.028
6 hsa04371 Apelin signaling pathway Environmental Information Processing Signal transduction NOS3 1 0.29 0.028
7 hsa04926 Relaxin signaling pathway Organismal Systems Endocrine system NOS3 1 0.13 0.031
8 hsa04611 Platelet activation Organismal Systems Immune system NOS3 1 0.13 0.033
9 hsa04071 Sphingolipid signaling pathway Environmental Information Processing Signal transduction NOS3 1 0.18 0.035
10 hsa04931 Insulin resistance Human Diseases Endocrine and metabolic diseases NOS3 1 0.15 0.038
11 hsa04066 HIF-1 signaling pathway Environmental Information Processing Signal transduction NOS3 1 0.2 0.041
12 hsa00330 Arginine and proline metabolism Metabolism Amino acid metabolism NOS3 1 0.32 0.045
13 hsa04370 VEGF signaling pathway Environmental Information Processing Signal transduction NOS3 1 0.23 0.045
14 hsa04933 AGE-RAGE signaling pathway in diabetic complications Human Diseases Endocrine and metabolic diseases NOS3 1 0.16 0.046
15 hsa00220 Arginine biosynthesis Metabolism Amino acid metabolism NOS3 1 0.34 0.048
16 hsa04151 PI3K-Akt signaling pathway Environmental Information Processing Signal transduction NOS3 1 0.19 0.05
17 hsa01100 Metabolic pathways Metabolism Global and overview maps NOS3 1 0.27 0.17


45 pathways for predicted targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa05032 Morphine addiction Human Diseases Substance dependence PDE10A;PDE4D;PDE4C;PDE4A;PDE4B;PDE3A 6 0.1 3.0E-6
2 hsa00230 Purine metabolism Metabolism Nucleotide metabolism PDE10A;PDE4D;PDE5A;PDE4B;PDE4A;PDE4C;PDE3A 7 0.14 3.0E-6
3 hsa04024 cAMP signaling pathway Environmental Information Processing Signal transduction PDE3A;PDE4D;PDE4C;CHRM1;PDE4A;PDE4B 6 0.19 9.8E-5
4 hsa04928 Parathyroid hormone synthesis, secretion and action Organismal Systems Endocrine system PDE4D;PDE4C;PDE4B;PDE4A 4 0.13 0.0014
5 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction HRH2;CHRM4;CHRM1;HTR2C 4 0.27 0.042
6 hsa04725 Cholinergic synapse Organismal Systems Nervous system CHRM4;CHRM1 2 0.11 0.24
7 hsa00670 One carbon pool by folate Metabolism Metabolism of cofactors and vitamins DHFR 1 0.44 0.32
8 hsa04726 Serotonergic synapse Organismal Systems Nervous system HTR2C 1 0.14 0.33
9 hsa05145 Toxoplasmosis Human Diseases Infectious diseases: Parasitic NOS2 1 0.12 0.33
10 hsa04668 TNF signaling pathway Environmental Information Processing Signal transduction MMP3 1 0.12 0.33
11 hsa04750 Inflammatory mediator regulation of TRP channels Organismal Systems Sensory system HTR2C 1 0.11 0.33
12 hsa05142 Chagas disease (American trypanosomiasis) Human Diseases Infectious diseases: Parasitic NOS2 1 0.11 0.33
13 hsa04659 Th17 cell differentiation Organismal Systems Immune system AHR 1 0.11 0.34
14 hsa05215 Prostate cancer Human Diseases Cancers: Specific types MMP3 1 0.12 0.34
15 hsa04142 Lysosome Cellular Processes Transport and catabolism CTSD 1 0.25 0.34
16 hsa04140 Autophagy - animal Cellular Processes Transport and catabolism CTSD 1 0.16 0.34
17 hsa05146 Amoebiasis Human Diseases Infectious diseases: Parasitic NOS2 1 0.15 0.34
18 hsa05152 Tuberculosis Human Diseases Infectious diseases: Bacterial NOS2;CTSD 2 0.1 0.34
19 hsa01523 Antifolate resistance Human Diseases Drug resistance: Antineoplastic DHFR 1 0.21 0.34
20 hsa04210 Apoptosis Cellular Processes Cell growth and death CTSD 1 0.13 0.35
21 hsa04713 Circadian entrainment Organismal Systems Environmental adaptation NOS1 1 0.13 0.35
22 hsa00790 Folate biosynthesis Metabolism Metabolism of cofactors and vitamins DHFR 1 0.2 0.36
23 hsa04657 IL-17 signaling pathway Organismal Systems Immune system MMP3 1 0.11 0.36
24 hsa05222 Small cell lung cancer Human Diseases Cancers: Specific types NOS2 1 0.11 0.37
25 hsa04145 Phagosome Cellular Processes Transport and catabolism NOS1 1 0.2 0.37
26 hsa04934 Cushing syndrome Human Diseases Endocrine and metabolic diseases AHR 1 0.11 0.37
27 hsa04630 JAK-STAT signaling pathway Environmental Information Processing Signal transduction PIM1 1 0.15 0.37
28 hsa04810 Regulation of actin cytoskeleton Cellular Processes Cell motility CHRM4;CHRM1 2 0.11 0.38
29 hsa00260 Glycine, serine and threonine metabolism Metabolism Amino acid metabolism GATM 1 0.3 0.38
30 hsa04970 Salivary secretion Organismal Systems Digestive system NOS1 1 0.11 0.38
31 hsa05010 Alzheimer disease Human Diseases Neurodegenerative diseases NOS1 1 0.11 0.38
32 hsa05323 Rheumatoid arthritis Human Diseases Immune diseases MMP3 1 0.18 0.39
33 hsa05202 Transcriptional misregulation in cancer Human Diseases Cancers: Overview MMP3 1 0.12 0.4
34 hsa05200 Pathways in cancer Human Diseases Cancers: Overview NOS2;PIM1 2 0.26 0.4
35 hsa04540 Gap junction Cellular Processes Cellular community - eukaryotes HTR2C 1 0.11 0.4
36 hsa05132 Salmonella infection Human Diseases Infectious diseases: Bacterial NOS2 1 0.17 0.41
37 hsa05133 Pertussis Human Diseases Infectious diseases: Bacterial NOS2 1 0.13 0.42
38 hsa04971 Gastric acid secretion Organismal Systems Digestive system HRH2 1 0.13 0.42
39 hsa05014 Amyotrophic lateral sclerosis (ALS) Human Diseases Neurodegenerative diseases NOS1 1 0.14 0.42
40 hsa04146 Peroxisome Cellular Processes Transport and catabolism NOS2 1 0.2 0.42
41 hsa05140 Leishmaniasis Human Diseases Infectious diseases: Parasitic NOS2 1 0.13 0.44
42 hsa05221 Acute myeloid leukemia Human Diseases Cancers: Specific types PIM1 1 0.18 0.44
43 hsa04924 Renin secretion Organismal Systems Endocrine system PDE3A 1 0.11 0.44
44 hsa04730 Long-term depression Organismal Systems Nervous system NOS1 1 0.2 0.46
45 hsa05206 MicroRNAs in cancer Human Diseases Cancers: Overview PIM1 1 0.11 0.54


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.