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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB02141


17 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa04915 Estrogen signaling pathway Organismal Systems Endocrine system NOS3 1 0.14 0.026
2 hsa05418 Fluid shear stress and atherosclerosis Human Diseases Cardiovascular diseases NOS3 1 0.14 0.026
3 hsa04921 Oxytocin signaling pathway Organismal Systems Endocrine system NOS3 1 0.14 0.026
4 hsa04022 cGMP-PKG signaling pathway Environmental Information Processing Signal transduction NOS3 1 0.14 0.026
5 hsa04020 Calcium signaling pathway Environmental Information Processing Signal transduction NOS3 1 0.19 0.028
6 hsa04371 Apelin signaling pathway Environmental Information Processing Signal transduction NOS3 1 0.29 0.028
7 hsa04926 Relaxin signaling pathway Organismal Systems Endocrine system NOS3 1 0.13 0.031
8 hsa04611 Platelet activation Organismal Systems Immune system NOS3 1 0.13 0.033
9 hsa04071 Sphingolipid signaling pathway Environmental Information Processing Signal transduction NOS3 1 0.18 0.035
10 hsa04931 Insulin resistance Human Diseases Endocrine and metabolic diseases NOS3 1 0.15 0.038
11 hsa04066 HIF-1 signaling pathway Environmental Information Processing Signal transduction NOS3 1 0.2 0.041
12 hsa00330 Arginine and proline metabolism Metabolism Amino acid metabolism NOS3 1 0.32 0.045
13 hsa04370 VEGF signaling pathway Environmental Information Processing Signal transduction NOS3 1 0.23 0.045
14 hsa04933 AGE-RAGE signaling pathway in diabetic complications Human Diseases Endocrine and metabolic diseases NOS3 1 0.16 0.046
15 hsa00220 Arginine biosynthesis Metabolism Amino acid metabolism NOS3 1 0.34 0.048
16 hsa04151 PI3K-Akt signaling pathway Environmental Information Processing Signal transduction NOS3 1 0.19 0.05
17 hsa01100 Metabolic pathways Metabolism Global and overview maps NOS3 1 0.27 0.17


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.