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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
The red circled blue spheres are used for the predicted targets.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB01234


19 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa04066 HIF-1 signaling pathway Environmental Information Processing Signal transduction NOS2 1 0.11 0.07
2 hsa05142 Chagas disease (American trypanosomiasis) Human Diseases Infectious diseases: Parasitic NOS2 1 0.11 0.07
3 hsa05145 Toxoplasmosis Human Diseases Infectious diseases: Parasitic NOS2 1 0.12 0.071
4 hsa04371 Apelin signaling pathway Environmental Information Processing Signal transduction NOS2 1 0.13 0.073
5 hsa04926 Relaxin signaling pathway Organismal Systems Endocrine system NOS2 1 0.11 0.073
6 hsa05146 Amoebiasis Human Diseases Infectious diseases: Parasitic NOS2 1 0.14 0.075
7 hsa05222 Small cell lung cancer Human Diseases Cancers: Specific types NOS2 1 0.11 0.08
8 hsa05152 Tuberculosis Human Diseases Infectious diseases: Bacterial NOS2 1 0.11 0.085
9 hsa04020 Calcium signaling pathway Environmental Information Processing Signal transduction NOS2 1 0.22 0.085
10 hsa05132 Salmonella infection Human Diseases Infectious diseases: Bacterial NOS2 1 0.15 0.088
11 hsa04146 Peroxisome Cellular Processes Transport and catabolism NOS2 1 0.23 0.093
12 hsa05133 Pertussis Human Diseases Infectious diseases: Bacterial NOS2 1 0.13 0.1
13 hsa05140 Leishmaniasis Human Diseases Infectious diseases: Parasitic NOS2 1 0.13 0.11
14 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction NR3C1 1 0.27 0.12
15 hsa04927 Cortisol synthesis and secretion Organismal Systems Endocrine system NR0B1 1 0.19 0.14
16 hsa00220 Arginine biosynthesis Metabolism Amino acid metabolism NOS2 1 0.19 0.16
17 hsa00330 Arginine and proline metabolism Metabolism Amino acid metabolism NOS2 1 0.17 0.16
18 hsa05200 Pathways in cancer Human Diseases Cancers: Overview NOS2 1 0.28 0.21
19 hsa01100 Metabolic pathways Metabolism Global and overview maps NOS2 1 0.27 0.43


70 pathways for predicted targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa04913 Ovarian steroidogenesis Organismal Systems Endocrine system HSD17B2;ALOX5;CYP17A1 3 0.19 0.01
2 hsa00140 Steroid hormone biosynthesis Metabolism Lipid metabolism HSD11B2;HSD17B2;CYP17A1 3 0.42 0.01
3 hsa04917 Prolactin signaling pathway Organismal Systems Endocrine system ESR2;CYP17A1;MAPK14 3 0.13 0.011
4 hsa04960 Aldosterone-regulated sodium reabsorption Organismal Systems Excretory system HSD11B2;NR3C2 2 0.35 0.054
5 hsa05014 Amyotrophic lateral sclerosis (ALS) Human Diseases Neurodegenerative diseases NOS1;MAPK14 2 0.16 0.081
6 hsa04370 VEGF signaling pathway Environmental Information Processing Signal transduction NOS3;MAPK14 2 0.15 0.088
7 hsa00590 Arachidonic acid metabolism Metabolism Lipid metabolism ALOX5;LTA4H 2 0.15 0.088
8 hsa04664 Fc epsilon RI signaling pathway Organismal Systems Immune system ALOX5;MAPK14 2 0.17 0.089
9 hsa04931 Insulin resistance Human Diseases Endocrine and metabolic diseases NOS3;PTPN1 2 0.13 0.14
10 hsa04659 Th17 cell differentiation Organismal Systems Immune system AHR;MAPK14 2 0.14 0.14
11 hsa04933 AGE-RAGE signaling pathway in diabetic complications Human Diseases Endocrine and metabolic diseases NOS3;MAPK14 2 0.13 0.15
12 hsa01522 Endocrine resistance Human Diseases Drug resistance: Antineoplastic ESR2;MAPK14 2 0.11 0.15
13 hsa04071 Sphingolipid signaling pathway Environmental Information Processing Signal transduction NOS3;MAPK14 2 0.14 0.16
14 hsa04611 Platelet activation Organismal Systems Immune system NOS3;MAPK14 2 0.11 0.16
15 hsa05418 Fluid shear stress and atherosclerosis Human Diseases Cardiovascular diseases NOS3;MAPK14 2 0.12 0.16
16 hsa04915 Estrogen signaling pathway Organismal Systems Endocrine system NOS3;ESR2 2 0.12 0.16
17 hsa04728 Dopaminergic synapse Organismal Systems Nervous system SCN1A;MAPK14 2 0.12 0.16
18 hsa04934 Cushing syndrome Human Diseases Endocrine and metabolic diseases AHR;CYP17A1 2 0.12 0.18
19 hsa05010 Alzheimer disease Human Diseases Neurodegenerative diseases CDK5R1;NOS1 2 0.13 0.21
20 hsa05167 Kaposi sarcoma-associated herpesvirus infection Human Diseases Infectious diseases: Viral BECN1;MAPK14 2 0.11 0.23
21 hsa04215 Apoptosis - multiple species Cellular Processes Cell growth and death BECN1 1 0.49 0.23
22 hsa04136 Autophagy - other Cellular Processes Transport and catabolism BECN1 1 0.27 0.23
23 hsa05030 Cocaine addiction Human Diseases Substance dependence CDK5R1 1 0.13 0.32
24 hsa04620 Toll-like receptor signaling pathway Organismal Systems Immune system MAPK14 1 0.16 0.35
25 hsa04625 C-type lectin receptor signaling pathway Organismal Systems Immune system MAPK14 1 0.13 0.35
26 hsa04670 Leukocyte transendothelial migration Organismal Systems Immune system MAPK14 1 0.3 0.36
27 hsa04668 TNF signaling pathway Environmental Information Processing Signal transduction MAPK14 1 0.16 0.36
28 hsa04726 Serotonergic synapse Organismal Systems Nervous system ALOX5 1 0.14 0.36
29 hsa04914 Progesterone-mediated oocyte maturation Organismal Systems Endocrine system MAPK14 1 0.11 0.36
30 hsa04660 T cell receptor signaling pathway Organismal Systems Immune system MAPK14 1 0.16 0.36
31 hsa04921 Oxytocin signaling pathway Organismal Systems Endocrine system NOS3 1 0.11 0.36
32 hsa04145 Phagosome Cellular Processes Transport and catabolism NOS1 1 0.28 0.36
33 hsa04722 Neurotrophin signaling pathway Organismal Systems Nervous system MAPK14 1 0.15 0.36
34 hsa04750 Inflammatory mediator regulation of TRP channels Organismal Systems Sensory system MAPK14 1 0.11 0.36
35 hsa04630 JAK-STAT signaling pathway Environmental Information Processing Signal transduction EPOR 1 0.18 0.37
36 hsa04022 cGMP-PKG signaling pathway Environmental Information Processing Signal transduction NOS3 1 0.12 0.37
37 hsa04068 FoxO signaling pathway Environmental Information Processing Signal transduction MAPK14 1 0.12 0.37
38 hsa05160 Hepatitis C Human Diseases Infectious diseases: Viral MAPK14 1 0.14 0.37
39 hsa04520 Adherens junction Cellular Processes Cellular community - eukaryotes PTPN1 1 0.17 0.37
40 hsa04622 RIG-I-like receptor signaling pathway Organismal Systems Immune system MAPK14 1 0.29 0.37
41 hsa05224 Breast cancer Human Diseases Cancers: Specific types ESR2 1 0.12 0.37
42 hsa04723 Retrograde endocannabinoid signaling Organismal Systems Nervous system MAPK14 1 0.11 0.37
43 hsa04621 NOD-like receptor signaling pathway Organismal Systems Immune system MAPK14 1 0.15 0.37
44 hsa05164 Influenza A Human Diseases Infectious diseases: Viral MAPK14 1 0.12 0.37
45 hsa04910 Insulin signaling pathway Organismal Systems Endocrine system PTPN1 1 0.14 0.37
46 hsa04550 Signaling pathways regulating pluripotency of stem cells Cellular Processes Cellular community - eukaryotes MAPK14 1 0.23 0.37
47 hsa04218 Cellular senescence Cellular Processes Cell growth and death MAPK14 1 0.12 0.37
48 hsa05120 Epithelial cell signaling in Helicobacter pylori infection Human Diseases Infectious diseases: Bacterial MAPK14 1 0.18 0.37
49 hsa04380 Osteoclast differentiation Organismal Systems Development MAPK14 1 0.12 0.37
50 hsa04140 Autophagy - animal Cellular Processes Transport and catabolism BECN1 1 0.18 0.37
51 hsa04261 Adrenergic signaling in cardiomyocytes Organismal Systems Circulatory system MAPK14 1 0.12 0.37
52 hsa05131 Shigellosis Human Diseases Infectious diseases: Bacterial MAPK14 1 0.21 0.37
53 hsa04137 Mitophagy - animal Cellular Processes Transport and catabolism BECN1 1 0.36 0.37
54 hsa04730 Long-term depression Organismal Systems Nervous system NOS1 1 0.25 0.37
55 hsa05215 Prostate cancer Human Diseases Cancers: Specific types KLK3 1 0.12 0.37
56 hsa04640 Hematopoietic cell lineage Organismal Systems Immune system EPOR 1 0.25 0.38
57 hsa04713 Circadian entrainment Organismal Systems Environmental adaptation NOS1 1 0.15 0.39
58 hsa04657 IL-17 signaling pathway Organismal Systems Immune system MAPK14 1 0.12 0.4
59 hsa04912 GnRH signaling pathway Organismal Systems Endocrine system MAPK14 1 0.16 0.4
60 hsa05205 Proteoglycans in cancer Human Diseases Cancers: Overview MAPK14 1 0.12 0.41
61 hsa05169 Epstein-Barr virus infection Human Diseases Infectious diseases: Viral MAPK14 1 0.12 0.41
62 hsa04151 PI3K-Akt signaling pathway Environmental Information Processing Signal transduction EPOR;NOS3 2 0.17 0.41
63 hsa04015 Rap1 signaling pathway Environmental Information Processing Signal transduction MAPK14 1 0.12 0.41
64 hsa05170 Human immunodeficiency virus 1 infection 0 0 MAPK14 1 0.13 0.41
65 hsa04658 Th1 and Th2 cell differentiation Organismal Systems Immune system MAPK14 1 0.22 0.42
66 hsa04714 Thermogenesis Organismal Systems Environmental adaptation MAPK14 1 0.16 0.42
67 hsa05163 Human cytomegalovirus infection 0 0 MAPK14 1 0.12 0.42
68 hsa04970 Salivary secretion Organismal Systems Digestive system NOS1 1 0.12 0.43
69 hsa04060 Cytokine-cytokine receptor interaction Environmental Information Processing Signaling molecules and interaction EPOR 1 0.2 0.5
70 hsa04010 MAPK signaling pathway Environmental Information Processing Signal transduction MAPK14 1 0.12 0.5


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.