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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB01234


19 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa04066 HIF-1 signaling pathway Environmental Information Processing Signal transduction NOS2 1 0.11 0.07
2 hsa05142 Chagas disease (American trypanosomiasis) Human Diseases Infectious diseases: Parasitic NOS2 1 0.11 0.07
3 hsa05145 Toxoplasmosis Human Diseases Infectious diseases: Parasitic NOS2 1 0.12 0.071
4 hsa04371 Apelin signaling pathway Environmental Information Processing Signal transduction NOS2 1 0.13 0.073
5 hsa04926 Relaxin signaling pathway Organismal Systems Endocrine system NOS2 1 0.11 0.073
6 hsa05146 Amoebiasis Human Diseases Infectious diseases: Parasitic NOS2 1 0.14 0.075
7 hsa05222 Small cell lung cancer Human Diseases Cancers: Specific types NOS2 1 0.11 0.08
8 hsa05152 Tuberculosis Human Diseases Infectious diseases: Bacterial NOS2 1 0.11 0.085
9 hsa04020 Calcium signaling pathway Environmental Information Processing Signal transduction NOS2 1 0.22 0.085
10 hsa05132 Salmonella infection Human Diseases Infectious diseases: Bacterial NOS2 1 0.15 0.088
11 hsa04146 Peroxisome Cellular Processes Transport and catabolism NOS2 1 0.23 0.093
12 hsa05133 Pertussis Human Diseases Infectious diseases: Bacterial NOS2 1 0.13 0.1
13 hsa05140 Leishmaniasis Human Diseases Infectious diseases: Parasitic NOS2 1 0.13 0.11
14 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction NR3C1 1 0.27 0.12
15 hsa04927 Cortisol synthesis and secretion Organismal Systems Endocrine system NR0B1 1 0.19 0.14
16 hsa00220 Arginine biosynthesis Metabolism Amino acid metabolism NOS2 1 0.19 0.16
17 hsa00330 Arginine and proline metabolism Metabolism Amino acid metabolism NOS2 1 0.17 0.16
18 hsa05200 Pathways in cancer Human Diseases Cancers: Overview NOS2 1 0.28 0.21
19 hsa01100 Metabolic pathways Metabolism Global and overview maps NOS2 1 0.27 0.43


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.