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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
The red circled blue spheres are used for the predicted targets.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB07119


6 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa05224 Breast cancer Human Diseases Cancers: Specific types NCOA1;ESR2 2 0.17 0.0012
2 hsa04915 Estrogen signaling pathway Organismal Systems Endocrine system NCOA1;ESR2 2 0.14 0.0012
3 hsa05200 Pathways in cancer Human Diseases Cancers: Overview NCOA1;ESR2 2 0.25 0.0099
4 hsa04917 Prolactin signaling pathway Organismal Systems Endocrine system ESR2 1 0.24 0.028
5 hsa01522 Endocrine resistance Human Diseases Drug resistance: Antineoplastic ESR2 1 0.14 0.031
6 hsa04919 Thyroid hormone signaling pathway Organismal Systems Endocrine system NCOA1 1 0.14 0.031


90 pathways for predicted targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa04913 Ovarian steroidogenesis Organismal Systems Endocrine system CYP19A1;INS;CYP1B1 3 0.15 0.01
2 hsa04914 Progesterone-mediated oocyte maturation Organismal Systems Endocrine system INS;PGR;MAPK14 3 0.11 0.034
3 hsa04931 Insulin resistance Human Diseases Endocrine and metabolic diseases PPARA;INS;PTPN1 3 0.11 0.034
4 hsa04910 Insulin signaling pathway Organismal Systems Endocrine system INS;PRKCI;PTPN1 3 0.12 0.053
5 hsa00140 Steroid hormone biosynthesis Metabolism Lipid metabolism CYP19A1;CYP1B1 2 0.25 0.11
6 hsa04015 Rap1 signaling pathway Environmental Information Processing Signal transduction INS;PRKCI;MAPK14 3 0.12 0.11
7 hsa05160 Hepatitis C Human Diseases Infectious diseases: Viral PPARA;MAPK14 2 0.12 0.25
8 hsa04068 FoxO signaling pathway Environmental Information Processing Signal transduction INS;MAPK14 2 0.11 0.25
9 hsa04114 Oocyte meiosis Cellular Processes Cell growth and death INS;PGR 2 0.11 0.28
10 hsa04611 Platelet activation Organismal Systems Immune system PRKCI;MAPK14 2 0.11 0.28
11 hsa04932 Non-alcoholic fatty liver disease (NAFLD) Human Diseases Endocrine and metabolic diseases PPARA;INS 2 0.12 0.29
12 hsa04620 Toll-like receptor signaling pathway Organismal Systems Immune system MAPK14 1 0.13 0.33
13 hsa04625 C-type lectin receptor signaling pathway Organismal Systems Immune system MAPK14 1 0.11 0.33
14 hsa04670 Leukocyte transendothelial migration Organismal Systems Immune system MAPK14 1 0.21 0.33
15 hsa05145 Toxoplasmosis Human Diseases Infectious diseases: Parasitic MAPK14 1 0.13 0.33
16 hsa04722 Neurotrophin signaling pathway Organismal Systems Nervous system MAPK14 1 0.13 0.33
17 hsa04152 AMPK signaling pathway Environmental Information Processing Signal transduction INS 1 0.13 0.33
18 hsa04659 Th17 cell differentiation Organismal Systems Immune system MAPK14 1 0.12 0.33
19 hsa04668 TNF signaling pathway Environmental Information Processing Signal transduction MAPK14 1 0.13 0.33
20 hsa04071 Sphingolipid signaling pathway Environmental Information Processing Signal transduction MAPK14 1 0.11 0.33
21 hsa04926 Relaxin signaling pathway Organismal Systems Endocrine system MAPK14 1 0.11 0.33
22 hsa04728 Dopaminergic synapse Organismal Systems Nervous system MAPK14 1 0.12 0.33
23 hsa04922 Glucagon signaling pathway Organismal Systems Endocrine system PPARA 1 0.13 0.33
24 hsa04380 Osteoclast differentiation Organismal Systems Development MAPK14 1 0.11 0.34
25 hsa04140 Autophagy - animal Cellular Processes Transport and catabolism INS 1 0.13 0.34
26 hsa05142 Chagas disease (American trypanosomiasis) Human Diseases Infectious diseases: Parasitic MAPK14 1 0.12 0.34
27 hsa05418 Fluid shear stress and atherosclerosis Human Diseases Cardiovascular diseases MAPK14 1 0.12 0.34
28 hsa04550 Signaling pathways regulating pluripotency of stem cells Cellular Processes Cellular community - eukaryotes MAPK14 1 0.19 0.34
29 hsa04660 T cell receptor signaling pathway Organismal Systems Immune system MAPK14 1 0.13 0.34
30 hsa04072 Phospholipase D signaling pathway Environmental Information Processing Signal transduction INS 1 0.13 0.34
31 hsa04723 Retrograde endocannabinoid signaling Organismal Systems Nervous system MAPK14 1 0.11 0.34
32 hsa04150 mTOR signaling pathway Environmental Information Processing Signal transduction INS 1 0.16 0.34
33 hsa04261 Adrenergic signaling in cardiomyocytes Organismal Systems Circulatory system MAPK14 1 0.12 0.34
34 hsa04390 Hippo signaling pathway Environmental Information Processing Signal transduction PRKCI 1 0.29 0.35
35 hsa04066 HIF-1 signaling pathway Environmental Information Processing Signal transduction INS 1 0.12 0.35
36 hsa04933 AGE-RAGE signaling pathway in diabetic complications Human Diseases Endocrine and metabolic diseases MAPK14 1 0.11 0.35
37 hsa04218 Cellular senescence Cellular Processes Cell growth and death MAPK14 1 0.11 0.35
38 hsa05164 Influenza A Human Diseases Infectious diseases: Viral MAPK14 1 0.11 0.35
39 hsa04530 Tight junction Cellular Processes Cellular community - eukaryotes PRKCI 1 0.16 0.35
40 hsa04022 cGMP-PKG signaling pathway Environmental Information Processing Signal transduction INS 1 0.12 0.35
41 hsa04750 Inflammatory mediator regulation of TRP channels Organismal Systems Sensory system MAPK14 1 0.11 0.36
42 hsa04621 NOD-like receptor signaling pathway Organismal Systems Immune system MAPK14 1 0.13 0.36
43 hsa04912 GnRH signaling pathway Organismal Systems Endocrine system MAPK14 1 0.14 0.36
44 hsa04657 IL-17 signaling pathway Organismal Systems Immune system MAPK14 1 0.11 0.36
45 hsa05152 Tuberculosis Human Diseases Infectious diseases: Bacterial MAPK14 1 0.11 0.36
46 hsa05215 Prostate cancer Human Diseases Cancers: Specific types INS 1 0.12 0.36
47 hsa05133 Pertussis Human Diseases Infectious diseases: Bacterial MAPK14 1 0.12 0.37
48 hsa00980 Metabolism of xenobiotics by cytochrome P450 Metabolism Xenobiotics biodegradation and metabolism CYP1B1 1 0.23 0.37
49 hsa04658 Th1 and Th2 cell differentiation Organismal Systems Immune system MAPK14 1 0.19 0.37
50 hsa04911 Insulin secretion Organismal Systems Endocrine system INS 1 0.13 0.37
51 hsa05132 Salmonella infection Human Diseases Infectious diseases: Bacterial MAPK14 1 0.14 0.37
52 hsa05167 Kaposi sarcoma-associated herpesvirus infection Human Diseases Infectious diseases: Viral MAPK14 1 0.11 0.37
53 hsa04211 Longevity regulating pathway Organismal Systems Aging INS 1 0.17 0.37
54 hsa04146 Peroxisome Cellular Processes Transport and catabolism ECI2 1 0.25 0.37
55 hsa05204 Chemical carcinogenesis Human Diseases Cancers: Overview CYP1B1 1 0.17 0.38
56 hsa03320 PPAR signaling pathway Organismal Systems Endocrine system PPARA 1 0.2 0.38
57 hsa05140 Leishmaniasis Human Diseases Infectious diseases: Parasitic MAPK14 1 0.13 0.38
58 hsa04744 Phototransduction Organismal Systems Sensory system RHO 1 0.19 0.38
59 hsa04950 Maturity onset diabetes of the young Human Diseases Endocrine and metabolic diseases INS 1 0.19 0.38
60 hsa04024 cAMP signaling pathway Environmental Information Processing Signal transduction PPARA 1 0.18 0.38
61 hsa05169 Epstein-Barr virus infection Human Diseases Infectious diseases: Viral MAPK14 1 0.11 0.38
62 hsa05205 Proteoglycans in cancer Human Diseases Cancers: Overview ESR1;MAPK14 2 0.13 0.39
63 hsa04520 Adherens junction Cellular Processes Cellular community - eukaryotes PTPN1 1 0.13 0.39
64 hsa04810 Regulation of actin cytoskeleton Cellular Processes Cell motility INS 1 0.12 0.39
65 hsa05170 Human immunodeficiency virus 1 infection 0 0 MAPK14 1 0.11 0.39
66 hsa04622 RIG-I-like receptor signaling pathway Organismal Systems Immune system MAPK14 1 0.21 0.39
67 hsa04920 Adipocytokine signaling pathway Organismal Systems Endocrine system PPARA 1 0.21 0.4
68 hsa04664 Fc epsilon RI signaling pathway Organismal Systems Immune system MAPK14 1 0.14 0.4
69 hsa05163 Human cytomegalovirus infection 0 0 MAPK14 1 0.12 0.4
70 hsa04714 Thermogenesis Organismal Systems Environmental adaptation MAPK14 1 0.13 0.4
71 hsa04014 Ras signaling pathway Environmental Information Processing Signal transduction INS 1 0.11 0.4
72 hsa04961 Endocrine and other factor-regulated calcium reabsorption Organismal Systems Excretory system ESR1 1 0.16 0.41
73 hsa04930 Type II diabetes mellitus Human Diseases Endocrine and metabolic diseases INS 1 0.15 0.41
74 hsa05120 Epithelial cell signaling in Helicobacter pylori infection Human Diseases Infectious diseases: Bacterial MAPK14 1 0.14 0.41
75 hsa04144 Endocytosis Cellular Processes Transport and catabolism PRKCI 1 0.2 0.42
76 hsa05014 Amyotrophic lateral sclerosis (ALS) Human Diseases Neurodegenerative diseases MAPK14 1 0.13 0.42
77 hsa00071 Fatty acid degradation Metabolism Lipid metabolism ECI2 1 0.34 0.42
78 hsa04923 Regulation of lipolysis in adipocytes Organismal Systems Endocrine system INS 1 0.11 0.42
79 hsa04010 MAPK signaling pathway Environmental Information Processing Signal transduction INS;MAPK14 2 0.12 0.42
80 hsa04213 Longevity regulating pathway - multiple species Organismal Systems Aging INS 1 0.22 0.42
81 hsa04940 Type I diabetes mellitus Human Diseases Endocrine and metabolic diseases INS 1 0.29 0.42
82 hsa05131 Shigellosis Human Diseases Infectious diseases: Bacterial MAPK14 1 0.18 0.43
83 hsa04960 Aldosterone-regulated sodium reabsorption Organismal Systems Excretory system INS 1 0.24 0.43
84 hsa00380 Tryptophan metabolism Metabolism Amino acid metabolism CYP1B1 1 0.27 0.44
85 hsa04370 VEGF signaling pathway Environmental Information Processing Signal transduction MAPK14 1 0.12 0.44
86 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction NR3C1 1 0.27 0.45
87 hsa05206 MicroRNAs in cancer Human Diseases Cancers: Overview CYP1B1 1 0.11 0.47
88 hsa05165 Human papillomavirus infection Human Diseases Infectious diseases: Viral PRKCI 1 0.12 0.51
89 hsa04151 PI3K-Akt signaling pathway Environmental Information Processing Signal transduction INS 1 0.17 0.52
90 hsa01100 Metabolic pathways Metabolism Global and overview maps CYP19A1 1 0.27 0.94


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.