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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
The red circled blue spheres are used for the predicted targets.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB07638


8 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa04917 Prolactin signaling pathway Organismal Systems Endocrine system ESR1;ESR2 2 0.21 0.00068
2 hsa01522 Endocrine resistance Human Diseases Drug resistance: Antineoplastic ESR1;ESR2 2 0.15 0.00068
3 hsa05224 Breast cancer Human Diseases Cancers: Specific types ESR1;ESR2 2 0.17 0.00077
4 hsa04915 Estrogen signaling pathway Organismal Systems Endocrine system ESR1;ESR2 2 0.14 0.00077
5 hsa05200 Pathways in cancer Human Diseases Cancers: Overview ESR1;ESR2 2 0.25 0.0079
6 hsa04961 Endocrine and other factor-regulated calcium reabsorption Organismal Systems Excretory system ESR1 1 0.3 0.017
7 hsa04919 Thyroid hormone signaling pathway Organismal Systems Endocrine system ESR1 1 0.15 0.035
8 hsa05205 Proteoglycans in cancer Human Diseases Cancers: Overview ESR1 1 0.14 0.053


40 pathways for predicted targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa04913 Ovarian steroidogenesis Organismal Systems Endocrine system HSD17B2;CYP19A1;HSD17B1;CYP1B1 4 0.16 0.00011
2 hsa00140 Steroid hormone biosynthesis Metabolism Lipid metabolism HSD17B2;CYP19A1;HSD17B1;CYP1B1 4 0.16 0.00012
3 hsa04114 Oocyte meiosis Cellular Processes Cell growth and death PGR;AR;CDK2 3 0.13 0.028
4 hsa04914 Progesterone-mediated oocyte maturation Organismal Systems Endocrine system PGR;CDK2 2 0.11 0.15
5 hsa05215 Prostate cancer Human Diseases Cancers: Specific types AR;CDK2 2 0.13 0.15
6 hsa05033 Nicotine addiction Human Diseases Substance dependence CHRNA4 1 0.13 0.3
7 hsa00380 Tryptophan metabolism Metabolism Amino acid metabolism CYP1B1 1 0.17 0.3
8 hsa04960 Aldosterone-regulated sodium reabsorption Organismal Systems Excretory system NR3C2 1 0.13 0.33
9 hsa05010 Alzheimer disease Human Diseases Neurodegenerative diseases MT-ATP6;APP 2 0.13 0.34
10 hsa04215 Apoptosis - multiple species Cellular Processes Cell growth and death BECN1 1 0.19 0.34
11 hsa04136 Autophagy - other Cellular Processes Transport and catabolism BECN1 1 0.15 0.34
12 hsa04218 Cellular senescence Cellular Processes Cell growth and death CDK2 1 0.12 0.39
13 hsa01100 Metabolic pathways Metabolism Global and overview maps HSD17B2;CYP19A1;HSD17B1;MT-ATP6 4 0.27 0.39
14 hsa04934 Cushing syndrome Human Diseases Endocrine and metabolic diseases CDK2 1 0.12 0.4
15 hsa05203 Viral carcinogenesis Human Diseases Cancers: Overview CDK2 1 0.12 0.4
16 hsa05169 Epstein-Barr virus infection Human Diseases Infectious diseases: Viral CDK2 1 0.12 0.4
17 hsa05226 Gastric cancer Human Diseases Cancers: Specific types CDK2 1 0.12 0.41
18 hsa05161 Hepatitis B Human Diseases Infectious diseases: Viral CDK2 1 0.11 0.41
19 hsa05012 Parkinson disease Human Diseases Neurodegenerative diseases MT-ATP6 1 0.15 0.41
20 hsa05016 Huntington disease Human Diseases Neurodegenerative diseases MT-ATP6 1 0.14 0.42
21 hsa05167 Kaposi sarcoma-associated herpesvirus infection Human Diseases Infectious diseases: Viral BECN1 1 0.11 0.42
22 hsa05168 Herpes simplex infection Human Diseases Infectious diseases: Viral CDK2 1 0.14 0.42
23 hsa04371 Apelin signaling pathway Environmental Information Processing Signal transduction BECN1 1 0.14 0.42
24 hsa00190 Oxidative phosphorylation Metabolism Energy metabolism MT-ATP6 1 0.19 0.43
25 hsa04115 p53 signaling pathway Cellular Processes Cell growth and death CDK2 1 0.13 0.43
26 hsa00980 Metabolism of xenobiotics by cytochrome P450 Metabolism Xenobiotics biodegradation and metabolism CYP1B1 1 0.13 0.43
27 hsa05204 Chemical carcinogenesis Human Diseases Cancers: Overview CYP1B1 1 0.17 0.43
28 hsa04068 FoxO signaling pathway Environmental Information Processing Signal transduction CDK2 1 0.12 0.43
29 hsa04137 Mitophagy - animal Cellular Processes Transport and catabolism BECN1 1 0.15 0.44
30 hsa04714 Thermogenesis Organismal Systems Environmental adaptation MT-ATP6 1 0.14 0.44
31 hsa05162 Measles Human Diseases Infectious diseases: Viral CDK2 1 0.13 0.45
32 hsa05222 Small cell lung cancer Human Diseases Cancers: Specific types CDK2 1 0.12 0.45
33 hsa04140 Autophagy - animal Cellular Processes Transport and catabolism BECN1 1 0.15 0.47
34 hsa04110 Cell cycle Cellular Processes Cell growth and death CDK2 1 0.14 0.48
35 hsa04725 Cholinergic synapse Organismal Systems Nervous system CHRNA4 1 0.11 0.49
36 hsa04726 Serotonergic synapse Organismal Systems Nervous system APP 1 0.14 0.49
37 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction CHRNA4 1 0.27 0.49
38 hsa05206 MicroRNAs in cancer Human Diseases Cancers: Overview CYP1B1 1 0.12 0.51
39 hsa05165 Human papillomavirus infection Human Diseases Infectious diseases: Viral CDK2 1 0.13 0.54
40 hsa04151 PI3K-Akt signaling pathway Environmental Information Processing Signal transduction CDK2 1 0.18 0.54


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.