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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
The red circled blue spheres are used for the predicted targets.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB03882


5 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa05224 Breast cancer Human Diseases Cancers: Specific types ESR2 1 0.15 0.025
2 hsa04915 Estrogen signaling pathway Organismal Systems Endocrine system ESR2 1 0.15 0.025
3 hsa01522 Endocrine resistance Human Diseases Drug resistance: Antineoplastic ESR2 1 0.15 0.031
4 hsa04917 Prolactin signaling pathway Organismal Systems Endocrine system ESR2 1 0.2 0.033
5 hsa05200 Pathways in cancer Human Diseases Cancers: Overview ESR2 1 0.25 0.07


38 pathways for predicted targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa04919 Thyroid hormone signaling pathway Organismal Systems Endocrine system ESR1;NCOA2;NCOA1 3 0.12 0.067
2 hsa04913 Ovarian steroidogenesis Organismal Systems Endocrine system HSD17B2;CYP1B1 2 0.099 0.087
3 hsa00140 Steroid hormone biosynthesis Metabolism Lipid metabolism HSD17B2;CYP1B1 2 0.1 0.087
4 hsa00980 Metabolism of xenobiotics by cytochrome P450 Metabolism Xenobiotics biodegradation and metabolism ADH1C;CYP1B1 2 0.1 0.098
5 hsa05204 Chemical carcinogenesis Human Diseases Cancers: Overview ADH1C;CYP1B1 2 0.1 0.098
6 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction PRSS3;HRH1;CHRNA4 3 0.27 0.13
7 hsa04114 Oocyte meiosis Cellular Processes Cell growth and death PGR;AR 2 0.11 0.15
8 hsa05033 Nicotine addiction Human Diseases Substance dependence CHRNA4 1 0.094 0.26
9 hsa00380 Tryptophan metabolism Metabolism Amino acid metabolism CYP1B1 1 0.11 0.26
10 hsa04961 Endocrine and other factor-regulated calcium reabsorption Organismal Systems Excretory system ESR1 1 0.1 0.26
11 hsa00071 Fatty acid degradation Metabolism Lipid metabolism ADH1C 1 0.15 0.26
12 hsa04215 Apoptosis - multiple species Cellular Processes Cell growth and death BECN1 1 0.11 0.28
13 hsa00350 Tyrosine metabolism Metabolism Amino acid metabolism ADH1C 1 0.09 0.28
14 hsa04136 Autophagy - other Cellular Processes Transport and catabolism BECN1 1 0.15 0.29
15 hsa00982 Drug metabolism - cytochrome P450 Metabolism Xenobiotics biodegradation and metabolism ADH1C 1 0.094 0.3
16 hsa00010 Glycolysis / Gluconeogenesis Metabolism Carbohydrate metabolism ADH1C 1 0.1 0.3
17 hsa00830 Retinol metabolism Metabolism Metabolism of cofactors and vitamins ADH1C 1 0.13 0.3
18 hsa04750 Inflammatory mediator regulation of TRP channels Organismal Systems Sensory system HRH1 1 0.11 0.3
19 hsa04914 Progesterone-mediated oocyte maturation Organismal Systems Endocrine system PGR 1 0.1 0.3
20 hsa00983 Drug metabolism - other enzymes Metabolism Xenobiotics biodegradation and metabolism CES1 1 0.09 0.31
21 hsa05215 Prostate cancer Human Diseases Cancers: Specific types AR 1 0.13 0.32
22 hsa04137 Mitophagy - animal Cellular Processes Transport and catabolism BECN1 1 0.1 0.32
23 hsa04972 Pancreatic secretion Organismal Systems Digestive system PRSS3 1 0.11 0.33
24 hsa04725 Cholinergic synapse Organismal Systems Nervous system CHRNA4 1 0.11 0.33
25 hsa04974 Protein digestion and absorption Organismal Systems Digestive system PRSS3 1 0.095 0.34
26 hsa05012 Parkinson disease Human Diseases Neurodegenerative diseases MT-ATP6 1 0.11 0.35
27 hsa04371 Apelin signaling pathway Environmental Information Processing Signal transduction BECN1 1 0.1 0.35
28 hsa00190 Oxidative phosphorylation Metabolism Energy metabolism MT-ATP6 1 0.11 0.35
29 hsa04140 Autophagy - animal Cellular Processes Transport and catabolism BECN1 1 0.094 0.35
30 hsa05010 Alzheimer disease Human Diseases Neurodegenerative diseases MT-ATP6 1 0.11 0.37
31 hsa05164 Influenza A Human Diseases Infectious diseases: Viral PRSS3 1 0.12 0.37
32 hsa05167 Kaposi sarcoma-associated herpesvirus infection Human Diseases Infectious diseases: Viral BECN1 1 0.1 0.37
33 hsa04020 Calcium signaling pathway Environmental Information Processing Signal transduction HRH1 1 0.19 0.37
34 hsa05016 Huntington disease Human Diseases Neurodegenerative diseases MT-ATP6 1 0.094 0.37
35 hsa05205 Proteoglycans in cancer Human Diseases Cancers: Overview ESR1 1 0.13 0.37
36 hsa01100 Metabolic pathways Metabolism Global and overview maps HSD17B2;MT-ATP6;ADH1C;CES1 4 0.27 0.37
37 hsa04714 Thermogenesis Organismal Systems Environmental adaptation MT-ATP6 1 0.11 0.4
38 hsa05206 MicroRNAs in cancer Human Diseases Cancers: Overview CYP1B1 1 0.12 0.48


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.