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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
The red circled blue spheres are used for the predicted targets.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB11755


9 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa04750 Inflammatory mediator regulation of TRP channels Organismal Systems Sensory system TRPM8;TRPV2;TRPA1 3 0.17 0.00039
2 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction CNR1;CNR2;HTR1A 3 0.27 0.0042
3 hsa04714 Thermogenesis Organismal Systems Environmental adaptation CNR1 1 0.3 0.17
4 hsa04015 Rap1 signaling pathway Environmental Information Processing Signal transduction CNR1 1 0.16 0.17
5 hsa04024 cAMP signaling pathway Environmental Information Processing Signal transduction HTR1A 1 0.2 0.17
6 hsa04723 Retrograde endocannabinoid signaling Organismal Systems Nervous system CNR1 1 0.16 0.19
7 hsa04621 NOD-like receptor signaling pathway Organismal Systems Immune system TRPV2 1 0.24 0.19
8 hsa04742 Taste transduction Organismal Systems Sensory system HTR1A 1 0.2 0.19
9 hsa04726 Serotonergic synapse Organismal Systems Nervous system HTR1A 1 0.17 0.2


21 pathways for predicted targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa04020 Calcium signaling pathway Environmental Information Processing Signal transduction HTR2A;CACNA1H;DRD5;VDAC1;CACNA1I;HTR2C;HTR7;HTR2B;CACNA1G 9 0.18 2.2E-9
2 hsa04540 Gap junction Cellular Processes Cellular community - eukaryotes DRD2;HTR2A;HTR2B;HTR2C 4 0.12 0.00051
3 hsa04927 Cortisol synthesis and secretion Organismal Systems Endocrine system CACNA1H;CACNA1I;CACNA1G 3 0.27 0.0031
4 hsa04713 Circadian entrainment Organismal Systems Environmental adaptation CACNA1H;CACNA1I;CACNA1G 3 0.18 0.0061
5 hsa04925 Aldosterone synthesis and secretion Organismal Systems Endocrine system CACNA1H;CACNA1I;CACNA1G 3 0.23 0.0061
6 hsa04728 Dopaminergic synapse Organismal Systems Nervous system DRD5;DRD2;DRD3 3 0.12 0.012
7 hsa04934 Cushing syndrome Human Diseases Endocrine and metabolic diseases CACNA1H;CACNA1I;CACNA1G 3 0.15 0.017
8 hsa04010 MAPK signaling pathway Environmental Information Processing Signal transduction CACNA1H;CACNA1I;CACNA1G 3 0.12 0.084
9 hsa05012 Parkinson disease Human Diseases Neurodegenerative diseases DRD2;VDAC1 2 0.17 0.11
10 hsa04022 cGMP-PKG signaling pathway Environmental Information Processing Signal transduction ADRA2B;VDAC1 2 0.12 0.11
11 hsa04218 Cellular senescence Cellular Processes Cell growth and death VDAC1;TRPV4 2 0.14 0.11
12 hsa05030 Cocaine addiction Human Diseases Substance dependence DRD2 1 0.15 0.17
13 hsa04979 Cholesterol metabolism Organismal Systems Digestive system VDAC1 1 0.18 0.17
14 hsa04930 Type II diabetes mellitus Human Diseases Endocrine and metabolic diseases CACNA1G 1 0.19 0.18
15 hsa05418 Fluid shear stress and atherosclerosis Human Diseases Cardiovascular diseases TRPV4 1 0.12 0.4
16 hsa05034 Alcoholism Human Diseases Substance dependence DRD2 1 0.13 0.41
17 hsa05164 Influenza A Human Diseases Infectious diseases: Viral VDAC1 1 0.13 0.41
18 hsa05016 Huntington disease Human Diseases Neurodegenerative diseases VDAC1 1 0.18 0.42
19 hsa04217 Necroptosis Cellular Processes Cell growth and death VDAC1 1 0.17 0.42
20 hsa04014 Ras signaling pathway Environmental Information Processing Signal transduction HTR7 1 0.13 0.46
21 hsa05166 Human T-cell leukemia virus 1 infection Human Diseases Infectious diseases: Viral VDAC1 1 0.16 0.47


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.