QuartataWeb
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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB11755


9 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa04750 Inflammatory mediator regulation of TRP channels Organismal Systems Sensory system TRPM8;TRPV2;TRPA1 3 0.17 0.00039
2 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction CNR1;CNR2;HTR1A 3 0.27 0.0042
3 hsa04714 Thermogenesis Organismal Systems Environmental adaptation CNR1 1 0.3 0.17
4 hsa04015 Rap1 signaling pathway Environmental Information Processing Signal transduction CNR1 1 0.16 0.17
5 hsa04024 cAMP signaling pathway Environmental Information Processing Signal transduction HTR1A 1 0.2 0.17
6 hsa04723 Retrograde endocannabinoid signaling Organismal Systems Nervous system CNR1 1 0.16 0.19
7 hsa04621 NOD-like receptor signaling pathway Organismal Systems Immune system TRPV2 1 0.24 0.19
8 hsa04742 Taste transduction Organismal Systems Sensory system HTR1A 1 0.2 0.19
9 hsa04726 Serotonergic synapse Organismal Systems Nervous system HTR1A 1 0.17 0.2


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.