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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
The red circled blue spheres are used for the predicted targets.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB00749


34 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa04923 Regulation of lipolysis in adipocytes Organismal Systems Endocrine system PTGS2;PTGS1 2 0.13 0.0036
2 hsa00590 Arachidonic acid metabolism Metabolism Lipid metabolism PTGS2;PTGS1 2 0.22 0.0036
3 hsa05222 Small cell lung cancer Human Diseases Cancers: Specific types PTGS2;RXRA 2 0.12 0.0052
4 hsa04726 Serotonergic synapse Organismal Systems Nervous system PTGS2;PTGS1 2 0.15 0.0059
5 hsa04668 TNF signaling pathway Environmental Information Processing Signal transduction PTGS2 1 0.15 0.074
6 hsa04659 Th17 cell differentiation Organismal Systems Immune system RXRA 1 0.14 0.074
7 hsa04919 Thyroid hormone signaling pathway Organismal Systems Endocrine system RXRA 1 0.11 0.074
8 hsa04611 Platelet activation Organismal Systems Immune system PTGS1 1 0.11 0.075
9 hsa05226 Gastric cancer Human Diseases Cancers: Specific types RXRA 1 0.12 0.075
10 hsa04921 Oxytocin signaling pathway Organismal Systems Endocrine system PTGS2 1 0.12 0.075
11 hsa04928 Parathyroid hormone synthesis, secretion and action Organismal Systems Endocrine system RXRA 1 0.18 0.076
12 hsa05160 Hepatitis C Human Diseases Infectious diseases: Viral RXRA 1 0.13 0.076
13 hsa04932 Non-alcoholic fatty liver disease (NAFLD) Human Diseases Endocrine and metabolic diseases RXRA 1 0.19 0.077
14 hsa05140 Leishmaniasis Human Diseases Infectious diseases: Parasitic PTGS2 1 0.17 0.077
15 hsa03320 PPAR signaling pathway Organismal Systems Endocrine system RXRA 1 0.43 0.077
16 hsa05204 Chemical carcinogenesis Human Diseases Cancers: Overview PTGS2 1 0.25 0.079
17 hsa04625 C-type lectin receptor signaling pathway Organismal Systems Immune system PTGS2 1 0.12 0.079
18 hsa04723 Retrograde endocannabinoid signaling Organismal Systems Nervous system PTGS2 1 0.11 0.08
19 hsa04657 IL-17 signaling pathway Organismal Systems Immune system PTGS2 1 0.12 0.08
20 hsa04064 NF-kappa B signaling pathway Environmental Information Processing Signal transduction PTGS2 1 0.18 0.08
21 hsa04976 Bile secretion Organismal Systems Digestive system RXRA 1 0.2 0.083
22 hsa05216 Thyroid cancer Human Diseases Cancers: Specific types RXRA 1 0.58 0.084
23 hsa05200 Pathways in cancer Human Diseases Cancers: Overview PTGS2;RXRA 2 0.26 0.084
24 hsa05167 Kaposi sarcoma-associated herpesvirus infection Human Diseases Infectious diseases: Viral PTGS2 1 0.11 0.085
25 hsa05202 Transcriptional misregulation in cancer Human Diseases Cancers: Overview RXRA 1 0.16 0.085
26 hsa04920 Adipocytokine signaling pathway Organismal Systems Endocrine system RXRA 1 0.28 0.087
27 hsa01100 Metabolic pathways Metabolism Global and overview maps PTGS2;PTGS1 2 0.27 0.09
28 hsa05223 Non-small cell lung cancer Human Diseases Cancers: Specific types RXRA 1 0.33 0.093
29 hsa04913 Ovarian steroidogenesis Organismal Systems Endocrine system PTGS2 1 0.25 0.095
30 hsa05163 Human cytomegalovirus infection 0 0 PTGS2 1 0.12 0.096
31 hsa04370 VEGF signaling pathway Environmental Information Processing Signal transduction PTGS2 1 0.14 0.099
32 hsa05206 MicroRNAs in cancer Human Diseases Cancers: Overview PTGS2 1 0.11 0.12
33 hsa05165 Human papillomavirus infection Human Diseases Infectious diseases: Viral PTGS2 1 0.13 0.13
34 hsa04151 PI3K-Akt signaling pathway Environmental Information Processing Signal transduction RXRA 1 0.18 0.14


65 pathways for predicted targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa05221 Acute myeloid leukemia Human Diseases Cancers: Specific types RARA;PPARD;NFKB1 3 0.15 0.022
2 hsa04915 Estrogen signaling pathway Organismal Systems Endocrine system RARA;NCOA2;NCOA1 3 0.12 0.092
3 hsa05145 Toxoplasmosis Human Diseases Infectious diseases: Parasitic ALOX5;NFKB1 2 0.12 0.22
4 hsa04931 Insulin resistance Human Diseases Endocrine and metabolic diseases PPARA;NFKB1 2 0.1 0.22
5 hsa04750 Inflammatory mediator regulation of TRP channels Organismal Systems Sensory system HRH1;TRPV1 2 0.1 0.23
6 hsa05215 Prostate cancer Human Diseases Cancers: Specific types GSTP1;NFKB1 2 0.12 0.24
7 hsa04380 Osteoclast differentiation Organismal Systems Development PPARG;NFKB1 2 0.1 0.24
8 hsa05418 Fluid shear stress and atherosclerosis Human Diseases Cardiovascular diseases GSTP1;NFKB1 2 0.11 0.25
9 hsa04211 Longevity regulating pathway Organismal Systems Aging PPARG;NFKB1 2 0.14 0.29
10 hsa04620 Toll-like receptor signaling pathway Organismal Systems Immune system NFKB1 1 0.12 0.33
11 hsa04922 Glucagon signaling pathway Organismal Systems Endocrine system PPARA 1 0.13 0.33
12 hsa05133 Pertussis Human Diseases Infectious diseases: Bacterial NFKB1 1 0.12 0.33
13 hsa05220 Chronic myeloid leukemia Human Diseases Cancers: Specific types NFKB1 1 0.17 0.33
14 hsa00983 Drug metabolism - other enzymes Metabolism Xenobiotics biodegradation and metabolism GSTP1 1 0.2 0.33
15 hsa05142 Chagas disease (American trypanosomiasis) Human Diseases Infectious diseases: Parasitic NFKB1 1 0.12 0.33
16 hsa04660 T cell receptor signaling pathway Organismal Systems Immune system NFKB1 1 0.12 0.34
17 hsa00980 Metabolism of xenobiotics by cytochrome P450 Metabolism Xenobiotics biodegradation and metabolism GSTP1 1 0.28 0.34
18 hsa05132 Salmonella infection Human Diseases Infectious diseases: Bacterial NFKB1 1 0.14 0.34
19 hsa04066 HIF-1 signaling pathway Environmental Information Processing Signal transduction NFKB1 1 0.12 0.34
20 hsa04152 AMPK signaling pathway Environmental Information Processing Signal transduction PPARG 1 0.12 0.35
21 hsa04722 Neurotrophin signaling pathway Organismal Systems Nervous system NFKB1 1 0.12 0.35
22 hsa04933 AGE-RAGE signaling pathway in diabetic complications Human Diseases Endocrine and metabolic diseases NFKB1 1 0.11 0.35
23 hsa05212 Pancreatic cancer Human Diseases Cancers: Specific types NFKB1 1 0.14 0.35
24 hsa04071 Sphingolipid signaling pathway Environmental Information Processing Signal transduction NFKB1 1 0.11 0.35
25 hsa04658 Th1 and Th2 cell differentiation Organismal Systems Immune system NFKB1 1 0.16 0.35
26 hsa05146 Amoebiasis Human Diseases Infectious diseases: Parasitic NFKB1 1 0.12 0.36
27 hsa04926 Relaxin signaling pathway Organismal Systems Endocrine system NFKB1 1 0.11 0.36
28 hsa05162 Measles Human Diseases Infectious diseases: Viral NFKB1 1 0.11 0.36
29 hsa01524 Platinum drug resistance Human Diseases Drug resistance: Antineoplastic GSTP1 1 0.17 0.36
30 hsa04210 Apoptosis Cellular Processes Cell growth and death NFKB1 1 0.12 0.36
31 hsa05224 Breast cancer Human Diseases Cancers: Specific types NCOA1 1 0.1 0.36
32 hsa04310 Wnt signaling pathway Environmental Information Processing Signal transduction PPARD 1 0.17 0.36
33 hsa00982 Drug metabolism - cytochrome P450 Metabolism Xenobiotics biodegradation and metabolism GSTP1 1 0.24 0.36
34 hsa05161 Hepatitis B Human Diseases Infectious diseases: Viral NFKB1 1 0.1 0.37
35 hsa04662 B cell receptor signaling pathway Organismal Systems Immune system NFKB1 1 0.18 0.37
36 hsa05164 Influenza A Human Diseases Infectious diseases: Viral NFKB1 1 0.11 0.38
37 hsa05225 Hepatocellular carcinoma Human Diseases Cancers: Specific types GSTP1 1 0.12 0.38
38 hsa04218 Cellular senescence Cellular Processes Cell growth and death NFKB1 1 0.11 0.38
39 hsa04621 NOD-like receptor signaling pathway Organismal Systems Immune system NFKB1 1 0.12 0.38
40 hsa05203 Viral carcinogenesis Human Diseases Cancers: Overview NFKB1 1 0.1 0.38
41 hsa05169 Epstein-Barr virus infection Human Diseases Infectious diseases: Viral NFKB1 1 0.1 0.38
42 hsa04062 Chemokine signaling pathway Organismal Systems Immune system NFKB1 1 0.12 0.38
43 hsa05016 Huntington disease Human Diseases Neurodegenerative diseases PPARG 1 0.13 0.38
44 hsa05168 Herpes simplex infection Human Diseases Infectious diseases: Viral NFKB1 1 0.11 0.38
45 hsa04020 Calcium signaling pathway Environmental Information Processing Signal transduction HRH1 1 0.18 0.38
46 hsa04622 RIG-I-like receptor signaling pathway Organismal Systems Immune system NFKB1 1 0.22 0.38
47 hsa05152 Tuberculosis Human Diseases Infectious diseases: Bacterial NFKB1 1 0.11 0.39
48 hsa01523 Antifolate resistance Human Diseases Drug resistance: Antineoplastic NFKB1 1 0.19 0.39
49 hsa04024 cAMP signaling pathway Environmental Information Processing Signal transduction PPARA;NFKB1 2 0.18 0.39
50 hsa05170 Human immunodeficiency virus 1 infection 0 0 NFKB1 1 0.11 0.39
51 hsa04917 Prolactin signaling pathway Organismal Systems Endocrine system NFKB1 1 0.11 0.4
52 hsa04714 Thermogenesis Organismal Systems Environmental adaptation PPARG 1 0.12 0.41
53 hsa04014 Ras signaling pathway Environmental Information Processing Signal transduction NFKB1 1 0.1 0.41
54 hsa05120 Epithelial cell signaling in Helicobacter pylori infection Human Diseases Infectious diseases: Bacterial NFKB1 1 0.13 0.41
55 hsa04664 Fc epsilon RI signaling pathway Organismal Systems Immune system ALOX5 1 0.12 0.42
56 hsa05166 Human T-cell leukemia virus 1 infection Human Diseases Infectious diseases: Viral NFKB1 1 0.11 0.43
57 hsa00830 Retinol metabolism Metabolism Metabolism of cofactors and vitamins CYP26C1 1 0.39 0.44
58 hsa05131 Shigellosis Human Diseases Infectious diseases: Bacterial NFKB1 1 0.15 0.46
59 hsa05321 Inflammatory bowel disease (IBD) Human Diseases Immune diseases NFKB1 1 0.34 0.47
60 hsa04010 MAPK signaling pathway Environmental Information Processing Signal transduction NFKB1 1 0.12 0.48
61 hsa04623 Cytosolic DNA-sensing pathway Organismal Systems Immune system NFKB1 1 0.39 0.5
62 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction HRH1;TRPV1 2 0.27 0.51
63 hsa00480 Glutathione metabolism Metabolism Metabolism of other amino acids GSTP1 1 0.38 0.51
64 hsa05134 Legionellosis Human Diseases Infectious diseases: Bacterial NFKB1 1 0.28 0.53
65 hsa05030 Cocaine addiction Human Diseases Substance dependence NFKB1 1 0.1 0.54


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.