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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB00749


34 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa04923 Regulation of lipolysis in adipocytes Organismal Systems Endocrine system PTGS2;PTGS1 2 0.13 0.0036
2 hsa00590 Arachidonic acid metabolism Metabolism Lipid metabolism PTGS2;PTGS1 2 0.22 0.0036
3 hsa05222 Small cell lung cancer Human Diseases Cancers: Specific types PTGS2;RXRA 2 0.12 0.0052
4 hsa04726 Serotonergic synapse Organismal Systems Nervous system PTGS2;PTGS1 2 0.15 0.0059
5 hsa04668 TNF signaling pathway Environmental Information Processing Signal transduction PTGS2 1 0.15 0.074
6 hsa04659 Th17 cell differentiation Organismal Systems Immune system RXRA 1 0.14 0.074
7 hsa04919 Thyroid hormone signaling pathway Organismal Systems Endocrine system RXRA 1 0.11 0.074
8 hsa04611 Platelet activation Organismal Systems Immune system PTGS1 1 0.11 0.075
9 hsa05226 Gastric cancer Human Diseases Cancers: Specific types RXRA 1 0.12 0.075
10 hsa04921 Oxytocin signaling pathway Organismal Systems Endocrine system PTGS2 1 0.12 0.075
11 hsa04928 Parathyroid hormone synthesis, secretion and action Organismal Systems Endocrine system RXRA 1 0.18 0.076
12 hsa05160 Hepatitis C Human Diseases Infectious diseases: Viral RXRA 1 0.13 0.076
13 hsa04932 Non-alcoholic fatty liver disease (NAFLD) Human Diseases Endocrine and metabolic diseases RXRA 1 0.19 0.077
14 hsa05140 Leishmaniasis Human Diseases Infectious diseases: Parasitic PTGS2 1 0.17 0.077
15 hsa03320 PPAR signaling pathway Organismal Systems Endocrine system RXRA 1 0.43 0.077
16 hsa05204 Chemical carcinogenesis Human Diseases Cancers: Overview PTGS2 1 0.25 0.079
17 hsa04625 C-type lectin receptor signaling pathway Organismal Systems Immune system PTGS2 1 0.12 0.079
18 hsa04723 Retrograde endocannabinoid signaling Organismal Systems Nervous system PTGS2 1 0.11 0.08
19 hsa04657 IL-17 signaling pathway Organismal Systems Immune system PTGS2 1 0.12 0.08
20 hsa04064 NF-kappa B signaling pathway Environmental Information Processing Signal transduction PTGS2 1 0.18 0.08
21 hsa04976 Bile secretion Organismal Systems Digestive system RXRA 1 0.2 0.083
22 hsa05216 Thyroid cancer Human Diseases Cancers: Specific types RXRA 1 0.58 0.084
23 hsa05200 Pathways in cancer Human Diseases Cancers: Overview PTGS2;RXRA 2 0.26 0.084
24 hsa05167 Kaposi sarcoma-associated herpesvirus infection Human Diseases Infectious diseases: Viral PTGS2 1 0.11 0.085
25 hsa05202 Transcriptional misregulation in cancer Human Diseases Cancers: Overview RXRA 1 0.16 0.085
26 hsa04920 Adipocytokine signaling pathway Organismal Systems Endocrine system RXRA 1 0.28 0.087
27 hsa01100 Metabolic pathways Metabolism Global and overview maps PTGS2;PTGS1 2 0.27 0.09
28 hsa05223 Non-small cell lung cancer Human Diseases Cancers: Specific types RXRA 1 0.33 0.093
29 hsa04913 Ovarian steroidogenesis Organismal Systems Endocrine system PTGS2 1 0.25 0.095
30 hsa05163 Human cytomegalovirus infection 0 0 PTGS2 1 0.12 0.096
31 hsa04370 VEGF signaling pathway Environmental Information Processing Signal transduction PTGS2 1 0.14 0.099
32 hsa05206 MicroRNAs in cancer Human Diseases Cancers: Overview PTGS2 1 0.11 0.12
33 hsa05165 Human papillomavirus infection Human Diseases Infectious diseases: Viral PTGS2 1 0.13 0.13
34 hsa04151 PI3K-Akt signaling pathway Environmental Information Processing Signal transduction RXRA 1 0.18 0.14


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.