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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB07080


16 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa04919 Thyroid hormone signaling pathway Organismal Systems Endocrine system RXRB;NCOA1;NCOA2 3 0.099 0.00057
2 hsa03320 PPAR signaling pathway Organismal Systems Endocrine system RXRB;NR1H3 2 0.2 0.0076
3 hsa04931 Insulin resistance Human Diseases Endocrine and metabolic diseases NR1H3;NR1H2 2 0.097 0.011
4 hsa04915 Estrogen signaling pathway Organismal Systems Endocrine system NCOA2;NCOA1 2 0.13 0.013
5 hsa05216 Thyroid cancer Human Diseases Cancers: Specific types RXRB 1 0.27 0.078
6 hsa05223 Non-small cell lung cancer Human Diseases Cancers: Specific types RXRB 1 0.16 0.091
7 hsa04920 Adipocytokine signaling pathway Organismal Systems Endocrine system RXRB 1 0.16 0.091
8 hsa05200 Pathways in cancer Human Diseases Cancers: Overview RXRB;NCOA1 2 0.25 0.099
9 hsa04659 Th17 cell differentiation Organismal Systems Immune system RXRB 1 0.12 0.1
10 hsa04928 Parathyroid hormone synthesis, secretion and action Organismal Systems Endocrine system RXRB 1 0.15 0.1
11 hsa05226 Gastric cancer Human Diseases Cancers: Specific types RXRB 1 0.1 0.1
12 hsa04932 Non-alcoholic fatty liver disease (NAFLD) Human Diseases Endocrine and metabolic diseases NR1H3 1 0.15 0.1
13 hsa05222 Small cell lung cancer Human Diseases Cancers: Specific types RXRB 1 0.11 0.11
14 hsa05224 Breast cancer Human Diseases Cancers: Specific types NCOA1 1 0.097 0.11
15 hsa05160 Hepatitis C Human Diseases Infectious diseases: Viral NR1H3 1 0.12 0.11
16 hsa05202 Transcriptional misregulation in cancer Human Diseases Cancers: Overview RXRB 1 0.14 0.12


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.