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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
The red circled blue spheres are used for the predicted targets.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB09064


7 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa05160 Hepatitis C Human Diseases Infectious diseases: Viral PPARA 1 0.088 0.023
2 hsa04932 Non-alcoholic fatty liver disease (NAFLD) Human Diseases Endocrine and metabolic diseases PPARA 1 0.095 0.023
3 hsa04931 Insulin resistance Human Diseases Endocrine and metabolic diseases PPARA 1 0.088 0.025
4 hsa04922 Glucagon signaling pathway Organismal Systems Endocrine system PPARA 1 0.095 0.025
5 hsa04024 cAMP signaling pathway Environmental Information Processing Signal transduction PPARA 1 0.18 0.027
6 hsa03320 PPAR signaling pathway Organismal Systems Endocrine system PPARA 1 0.14 0.032
7 hsa04920 Adipocytokine signaling pathway Organismal Systems Endocrine system PPARA 1 0.1 0.035


68 pathways for predicted targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa04919 Thyroid hormone signaling pathway Organismal Systems Endocrine system ESR1;RXRA;NCOA1;RXRG 4 0.11 0.0032
2 hsa05200 Pathways in cancer Human Diseases Cancers: Overview PPARD;NCOA1;CDK2;PPARG;ESR1;RXRG;RXRA 7 0.26 0.0032
3 hsa05216 Thyroid cancer Human Diseases Cancers: Specific types RXRG;PPARG;RXRA 3 0.13 0.0045
4 hsa05202 Transcriptional misregulation in cancer Human Diseases Cancers: Overview RXRG;MMP3;PPARG;RXRA 4 0.13 0.015
5 hsa05222 Small cell lung cancer Human Diseases Cancers: Specific types CDK2;RXRA;RXRG 3 0.12 0.018
6 hsa00592 alpha-Linolenic acid metabolism Metabolism Lipid metabolism PLA2G2A;PLA2G2D 2 0.17 0.018
7 hsa00591 Linoleic acid metabolism Metabolism Lipid metabolism PLA2G2A;PLA2G2D 2 0.12 0.021
8 hsa04975 Fat digestion and absorption Organismal Systems Digestive system PLA2G2A;PLA2G2D 2 0.12 0.036
9 hsa05226 Gastric cancer Human Diseases Cancers: Specific types CDK2;RXRA;RXRG 3 0.12 0.038
10 hsa00565 Ether lipid metabolism Metabolism Lipid metabolism PLA2G2A;PLA2G2D 2 0.14 0.038
11 hsa00590 Arachidonic acid metabolism Metabolism Lipid metabolism PLA2G2A;PLA2G2D 2 0.13 0.061
12 hsa05223 Non-small cell lung cancer Human Diseases Cancers: Specific types RXRA;RXRG 2 0.14 0.061
13 hsa05215 Prostate cancer Human Diseases Cancers: Specific types MMP3;CDK2 2 0.13 0.095
14 hsa00564 Glycerophospholipid metabolism Metabolism Lipid metabolism PLA2G2A;PLA2G2D 2 0.12 0.095
15 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction MTNR1A;MTNR1B;TRPV1 3 0.27 0.097
16 hsa04659 Th17 cell differentiation Organismal Systems Immune system RXRA;RXRG 2 0.12 0.097
17 hsa04972 Pancreatic secretion Organismal Systems Digestive system PLA2G2A;PLA2G2D 2 0.11 0.1
18 hsa04928 Parathyroid hormone synthesis, secretion and action Organismal Systems Endocrine system RXRA;RXRG 2 0.12 0.1
19 hsa04270 Vascular smooth muscle contraction Organismal Systems Circulatory system PLA2G2A;PLA2G2D 2 0.11 0.1
20 hsa04152 AMPK signaling pathway Environmental Information Processing Signal transduction PPARG;SREBF1 2 0.13 0.1
21 hsa00061 Fatty acid biosynthesis Metabolism Lipid metabolism ACSL4 1 0.17 0.11
22 hsa04713 Circadian entrainment Organismal Systems Environmental adaptation MTNR1A;MTNR1B 2 0.12 0.11
23 hsa04915 Estrogen signaling pathway Organismal Systems Endocrine system ESR1;NCOA1 2 0.13 0.12
24 hsa05224 Breast cancer Human Diseases Cancers: Specific types ESR1;NCOA1 2 0.11 0.14
25 hsa04913 Ovarian steroidogenesis Organismal Systems Endocrine system CYP19A1 1 0.12 0.24
26 hsa01212 Fatty acid metabolism Metabolism Global and overview maps ACSL4 1 0.22 0.24
27 hsa04961 Endocrine and other factor-regulated calcium reabsorption Organismal Systems Excretory system ESR1 1 0.12 0.24
28 hsa04216 Ferroptosis Cellular Processes Cell growth and death ACSL4 1 0.13 0.24
29 hsa00260 Glycine, serine and threonine metabolism Metabolism Amino acid metabolism PGAM2 1 0.14 0.24
30 hsa04014 Ras signaling pathway Environmental Information Processing Signal transduction PLA2G2A;PLA2G2D 2 0.11 0.24
31 hsa04714 Thermogenesis Organismal Systems Environmental adaptation ACSL4;PPARG 2 0.13 0.25
32 hsa00071 Fatty acid degradation Metabolism Lipid metabolism ACSL4 1 0.12 0.25
33 hsa00140 Steroid hormone biosynthesis Metabolism Lipid metabolism CYP19A1 1 0.13 0.27
34 hsa04115 p53 signaling pathway Cellular Processes Cell growth and death CDK2 1 0.12 0.28
35 hsa04976 Bile secretion Organismal Systems Digestive system RXRA 1 0.12 0.28
36 hsa01230 Biosynthesis of amino acids Metabolism Global and overview maps PGAM2 1 0.11 0.28
37 hsa04917 Prolactin signaling pathway Organismal Systems Endocrine system ESR1 1 0.12 0.28
38 hsa00010 Glycolysis / Gluconeogenesis Metabolism Carbohydrate metabolism PGAM2 1 0.12 0.29
39 hsa05221 Acute myeloid leukemia Human Diseases Cancers: Specific types PPARD 1 0.13 0.29
40 hsa05230 Central carbon metabolism in cancer Human Diseases Cancers: Overview PGAM2 1 0.14 0.29
41 hsa04750 Inflammatory mediator regulation of TRP channels Organismal Systems Sensory system TRPV1 1 0.11 0.29
42 hsa04914 Progesterone-mediated oocyte maturation Organismal Systems Endocrine system CDK2 1 0.11 0.29
43 hsa04742 Taste transduction Organismal Systems Sensory system SCN3A 1 0.11 0.3
44 hsa04146 Peroxisome Cellular Processes Transport and catabolism ACSL4 1 0.11 0.3
45 hsa05323 Rheumatoid arthritis Human Diseases Immune diseases MMP3 1 0.13 0.3
46 hsa04211 Longevity regulating pathway Organismal Systems Aging PPARG 1 0.12 0.3
47 hsa01522 Endocrine resistance Human Diseases Drug resistance: Antineoplastic ESR1 1 0.1 0.3
48 hsa01100 Metabolic pathways Metabolism Global and overview maps PLA2G2A;ACSL4;PLA2G2D;PGAM2;CYP19A1 5 0.27 0.3
49 hsa04657 IL-17 signaling pathway Organismal Systems Immune system MMP3 1 0.11 0.3
50 hsa04151 PI3K-Akt signaling pathway Environmental Information Processing Signal transduction CDK2;RXRA 2 0.18 0.3
51 hsa04668 TNF signaling pathway Environmental Information Processing Signal transduction MMP3 1 0.13 0.31
52 hsa01200 Carbon metabolism Metabolism Global and overview maps PGAM2 1 0.13 0.32
53 hsa05162 Measles Human Diseases Infectious diseases: Viral CDK2 1 0.12 0.33
54 hsa04068 FoxO signaling pathway Environmental Information Processing Signal transduction CDK2 1 0.12 0.33
55 hsa04114 Oocyte meiosis Cellular Processes Cell growth and death CDK2 1 0.12 0.33
56 hsa04110 Cell cycle Cellular Processes Cell growth and death CDK2 1 0.12 0.33
57 hsa04380 Osteoclast differentiation Organismal Systems Development PPARG 1 0.11 0.33
58 hsa04910 Insulin signaling pathway Organismal Systems Endocrine system SREBF1 1 0.12 0.33
59 hsa05161 Hepatitis B Human Diseases Infectious diseases: Viral CDK2 1 0.1 0.34
60 hsa04310 Wnt signaling pathway Environmental Information Processing Signal transduction PPARD 1 0.14 0.34
61 hsa04934 Cushing syndrome Human Diseases Endocrine and metabolic diseases CDK2 1 0.11 0.35
62 hsa04218 Cellular senescence Cellular Processes Cell growth and death CDK2 1 0.11 0.35
63 hsa05168 Herpes simplex infection Human Diseases Infectious diseases: Viral CDK2 1 0.12 0.39
64 hsa05203 Viral carcinogenesis Human Diseases Cancers: Overview CDK2 1 0.11 0.39
65 hsa05169 Epstein-Barr virus infection Human Diseases Infectious diseases: Viral CDK2 1 0.11 0.39
66 hsa05016 Huntington disease Human Diseases Neurodegenerative diseases PPARG 1 0.12 0.4
67 hsa05205 Proteoglycans in cancer Human Diseases Cancers: Overview ESR1 1 0.13 0.4
68 hsa05165 Human papillomavirus infection Human Diseases Infectious diseases: Viral CDK2 1 0.13 0.57


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.