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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
The red circled blue spheres are used for the predicted targets.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB01296


75 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)
1 hsa04657 IL-17 signaling pathway Organismal Systems Immune system TNF;MMP9;IFNG 3 0.1 0.00056
2 hsa05418 Fluid shear stress and atherosclerosis Human Diseases Cardiovascular diseases TNF;MMP9;IFNG 3 0.11 0.00062
3 hsa04380 Osteoclast differentiation Organismal Systems Development NFKB2;TNF;IFNG 3 0.1 0.00062
4 hsa05332 Graft-versus-host disease Human Diseases Immune diseases TNF;IFNG 2 0.24 0.0021
5 hsa04940 Type I diabetes mellitus Human Diseases Endocrine and metabolic diseases TNF;IFNG 2 0.23 0.0021
6 hsa05330 Allograft rejection Human Diseases Immune diseases TNF;IFNG 2 0.28 0.0022
7 hsa05143 African trypanosomiasis Human Diseases Infectious diseases: Parasitic TNF;IFNG 2 0.22 0.0023
8 hsa05144 Malaria Human Diseases Infectious diseases: Parasitic TNF;IFNG 2 0.18 0.0024
9 hsa05134 Legionellosis Human Diseases Infectious diseases: Bacterial TNF;NFKB2 2 0.19 0.0026
10 hsa05321 Inflammatory bowel disease (IBD) Human Diseases Immune diseases TNF;IFNG 2 0.19 0.0033
11 hsa05140 Leishmaniasis Human Diseases Infectious diseases: Parasitic TNF;IFNG 2 0.12 0.0039
12 hsa04612 Antigen processing and presentation Organismal Systems Immune system TNF;IFNG 2 0.17 0.0039
13 hsa04350 TGF-beta signaling pathway Environmental Information Processing Signal transduction TNF;IFNG 2 0.22 0.0043
14 hsa05142 Chagas disease (American trypanosomiasis) Human Diseases Infectious diseases: Parasitic TNF;IFNG 2 0.11 0.0045
15 hsa04625 C-type lectin receptor signaling pathway Organismal Systems Immune system TNF;NFKB2 2 0.099 0.0045
16 hsa05146 Amoebiasis Human Diseases Infectious diseases: Parasitic TNF;IFNG 2 0.12 0.0045
17 hsa04064 NF-kappa B signaling pathway Environmental Information Processing Signal transduction TNF;NFKB2 2 0.12 0.0045
18 hsa04660 T cell receptor signaling pathway Organismal Systems Immune system TNF;IFNG 2 0.12 0.0045
19 hsa05323 Rheumatoid arthritis Human Diseases Immune diseases TNF;IFNG 2 0.14 0.0045
20 hsa05145 Toxoplasmosis Human Diseases Infectious diseases: Parasitic TNF;IFNG 2 0.12 0.0045
21 hsa05200 Pathways in cancer Human Diseases Cancers: Overview NFKB2;MMP9;IFNG 3 0.25 0.0045
22 hsa04668 TNF signaling pathway Environmental Information Processing Signal transduction TNF;MMP9 2 0.12 0.0047
23 hsa05322 Systemic lupus erythematosus Human Diseases Immune diseases TNF;IFNG 2 0.19 0.0058
24 hsa04650 Natural killer cell mediated cytotoxicity Organismal Systems Immune system TNF;IFNG 2 0.14 0.0058
25 hsa05161 Hepatitis B Human Diseases Infectious diseases: Viral TNF;MMP9 2 0.1 0.0065
26 hsa04217 Necroptosis Cellular Processes Cell growth and death TNF;IFNG 2 0.12 0.0079
27 hsa05164 Influenza A Human Diseases Infectious diseases: Viral TNF;IFNG 2 0.1 0.0084
28 hsa05152 Tuberculosis Human Diseases Infectious diseases: Bacterial TNF;IFNG 2 0.1 0.0089
29 hsa05168 Herpes simplex infection Human Diseases Infectious diseases: Viral TNF;IFNG 2 0.11 0.0092
30 hsa05205 Proteoglycans in cancer Human Diseases Cancers: Overview TNF;MMP9 2 0.12 0.01
31 hsa05169 Epstein-Barr virus infection Human Diseases Infectious diseases: Viral NFKB2;IFNG 2 0.1 0.01
32 hsa05166 Human T-cell leukemia virus 1 infection Human Diseases Infectious diseases: Viral TNF;NFKB2 2 0.1 0.016
33 hsa04010 MAPK signaling pathway Environmental Information Processing Signal transduction TNF;NFKB2 2 0.12 0.02
34 hsa04060 Cytokine-cytokine receptor interaction Environmental Information Processing Signaling molecules and interaction TNF;IFNG 2 0.13 0.02
35 hsa05310 Asthma Human Diseases Immune diseases TNF 1 0.35 0.034
36 hsa01523 Antifolate resistance Human Diseases Drug resistance: Antineoplastic TNF 1 0.15 0.034
37 hsa05219 Bladder cancer Human Diseases Cancers: Specific types MMP9 1 0.15 0.044
38 hsa04930 Type II diabetes mellitus Human Diseases Endocrine and metabolic diseases TNF 1 0.13 0.047
39 hsa03050 Proteasome Genetic Information Processing Folding, sorting and degradation IFNG 1 0.22 0.047
40 hsa05014 Amyotrophic lateral sclerosis (ALS) Human Diseases Neurodegenerative diseases TNF 1 0.12 0.051
41 hsa04622 RIG-I-like receptor signaling pathway Organismal Systems Immune system TNF 1 0.15 0.064
42 hsa04920 Adipocytokine signaling pathway Organismal Systems Endocrine system TNF 1 0.15 0.064
43 hsa04664 Fc epsilon RI signaling pathway Organismal Systems Immune system TNF 1 0.12 0.065
44 hsa05133 Pertussis Human Diseases Infectious diseases: Bacterial TNF 1 0.12 0.068
45 hsa05410 Hypertrophic cardiomyopathy (HCM) Human Diseases Cardiovascular diseases TNF 1 0.15 0.073
46 hsa05132 Salmonella infection Human Diseases Infectious diseases: Bacterial IFNG 1 0.13 0.074
47 hsa04933 AGE-RAGE signaling pathway in diabetic complications Human Diseases Endocrine and metabolic diseases TNF 1 0.099 0.074
48 hsa04066 HIF-1 signaling pathway Environmental Information Processing Signal transduction IFNG 1 0.11 0.074
49 hsa01522 Endocrine resistance Human Diseases Drug resistance: Antineoplastic MMP9 1 0.1 0.075
50 hsa04931 Insulin resistance Human Diseases Endocrine and metabolic diseases TNF 1 0.1 0.075
51 hsa04659 Th17 cell differentiation Organismal Systems Immune system IFNG 1 0.11 0.075
52 hsa05414 Dilated cardiomyopathy (DCM) Human Diseases Cardiovascular diseases TNF 1 0.12 0.076
53 hsa04658 Th1 and Th2 cell differentiation Organismal Systems Immune system IFNG 1 0.14 0.076
54 hsa05215 Prostate cancer Human Diseases Cancers: Specific types MMP9 1 0.12 0.076
55 hsa04620 Toll-like receptor signaling pathway Organismal Systems Immune system TNF 1 0.12 0.076
56 hsa04640 Hematopoietic cell lineage Organismal Systems Immune system TNF 1 0.15 0.076
57 hsa04670 Leukocyte transendothelial migration Organismal Systems Immune system MMP9 1 0.16 0.077
58 hsa04071 Sphingolipid signaling pathway Environmental Information Processing Signal transduction TNF 1 0.1 0.08
59 hsa05162 Measles Human Diseases Infectious diseases: Viral IFNG 1 0.1 0.085
60 hsa05160 Hepatitis C Human Diseases Infectious diseases: Viral TNF 1 0.11 0.085
61 hsa04210 Apoptosis Cellular Processes Cell growth and death TNF 1 0.12 0.085
62 hsa04915 Estrogen signaling pathway Organismal Systems Endocrine system MMP9 1 0.12 0.085
63 hsa04926 Relaxin signaling pathway Organismal Systems Endocrine system MMP9 1 0.1 0.085
64 hsa04150 mTOR signaling pathway Environmental Information Processing Signal transduction TNF 1 0.13 0.089
65 hsa04932 Non-alcoholic fatty liver disease (NAFLD) Human Diseases Endocrine and metabolic diseases TNF 1 0.12 0.089
66 hsa05224 Breast cancer Human Diseases Cancers: Specific types NFKB2 1 0.1 0.089
67 hsa04630 JAK-STAT signaling pathway Environmental Information Processing Signal transduction IFNG 1 0.13 0.094
68 hsa04621 NOD-like receptor signaling pathway Organismal Systems Immune system TNF 1 0.12 0.096
69 hsa05010 Alzheimer disease Human Diseases Neurodegenerative diseases TNF 1 0.1 0.096
70 hsa05202 Transcriptional misregulation in cancer Human Diseases Cancers: Overview MMP9 1 0.12 0.1
71 hsa05203 Viral carcinogenesis Human Diseases Cancers: Overview NFKB2 1 0.1 0.11
72 hsa05170 Human immunodeficiency virus 1 infection 0 0 TNF 1 0.1 0.11
73 hsa05163 Human cytomegalovirus infection 0 0 TNF 1 0.11 0.12
74 hsa05206 MicroRNAs in cancer Human Diseases Cancers: Overview MMP9 1 0.1 0.15
75 hsa05165 Human papillomavirus infection Human Diseases Infectious diseases: Viral TNF 1 0.12 0.17


75 pathways for predicted targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)
1 hsa01521 EGFR tyrosine kinase inhibitor resistance Human Diseases Drug resistance: Antineoplastic VEGFA;IL6;FGFR2;EGFR 4 0.11 0.0015
2 hsa05212 Pancreatic cancer Human Diseases Cancers: Specific types VEGFA;TGFBR2;NFKB1;EGFR 4 0.094 0.0015
3 hsa05020 Prion diseases Human Diseases Neurodegenerative diseases IL6;HSPA5;IL1B 3 0.16 0.0022
4 hsa04151 PI3K-Akt signaling pathway Environmental Information Processing Signal transduction IL6;VEGFA;EGFR;IL2;FGFR2;NFKB1 6 0.17 0.0033
5 hsa05120 Epithelial cell signaling in Helicobacter pylori infection Human Diseases Infectious diseases: Bacterial CASP3;NFKB1;EGFR 3 0.095 0.0073
6 hsa04917 Prolactin signaling pathway Organismal Systems Endocrine system ESR1;NFKB1;ESR2 3 0.1 0.0073
7 hsa04623 Cytosolic DNA-sensing pathway Organismal Systems Immune system IL6;IL1B;NFKB1 3 0.17 0.0075
8 hsa05167 Kaposi sarcoma-associated herpesvirus infection Human Diseases Infectious diseases: Viral VEGFA;IL6;CASP3;NFKB1 4 0.1 0.01
9 hsa05210 Colorectal cancer Human Diseases Cancers: Specific types TGFBR2;CASP3;EGFR 3 0.094 0.01
10 hsa04014 Ras signaling pathway Environmental Information Processing Signal transduction VEGFA;FGFR2;NFKB1;EGFR 4 0.1 0.018
11 hsa04068 FoxO signaling pathway Environmental Information Processing Signal transduction TGFBR2;IL6;EGFR 3 0.1 0.029
12 hsa05226 Gastric cancer Human Diseases Cancers: Specific types TGFBR2;FGFR2;EGFR 3 0.1 0.037
13 hsa04672 Intestinal immune network for IgA production Organismal Systems Immune system IL6;IL2 2 0.17 0.039
14 hsa04218 Cellular senescence Cellular Processes Cell growth and death TGFBR2;IL6;NFKB1 3 0.1 0.039
15 hsa04020 Calcium signaling pathway Environmental Information Processing Signal transduction EGFR;EDNRB;EDNRA 3 0.18 0.052
16 hsa05230 Central carbon metabolism in cancer Human Diseases Cancers: Overview FGFR2;EGFR 2 0.11 0.053
17 hsa05221 Acute myeloid leukemia Human Diseases Cancers: Specific types PPARD;NFKB1 2 0.1 0.053
18 hsa04015 Rap1 signaling pathway Environmental Information Processing Signal transduction VEGFA;FGFR2;EGFR 3 0.12 0.057
19 hsa04520 Adherens junction Cellular Processes Cellular community - eukaryotes TGFBR2;EGFR 2 0.091 0.057
20 hsa05220 Chronic myeloid leukemia Human Diseases Cancers: Specific types TGFBR2;NFKB1 2 0.14 0.059
21 hsa05222 Small cell lung cancer Human Diseases Cancers: Specific types CASP3;NFKB1 2 0.11 0.078
22 hsa04144 Endocytosis Cellular Processes Transport and catabolism TGFBR2;FGFR2;EGFR 3 0.12 0.078
23 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction NR3C1;EDNRB;EDNRA 3 0.27 0.1
24 hsa03060 Protein export Genetic Information Processing Folding, sorting and degradation HSPA5 1 0.082 0.18
25 hsa04022 cGMP-PKG signaling pathway Environmental Information Processing Signal transduction EDNRB;EDNRA 2 0.13 0.19
26 hsa05225 Hepatocellular carcinoma Human Diseases Cancers: Specific types TGFBR2;EGFR 2 0.092 0.19
27 hsa04215 Apoptosis - multiple species Cellular Processes Cell growth and death CASP3 1 0.14 0.22
28 hsa03410 Base excision repair Genetic Information Processing Replication and repair HMGB1 1 0.19 0.22
29 hsa04024 cAMP signaling pathway Environmental Information Processing Signal transduction NFKB1;EDNRA 2 0.18 0.22
30 hsa04510 Focal adhesion Cellular Processes Cellular community - eukaryotes VEGFA;EGFR 2 0.1 0.22
31 hsa04810 Regulation of actin cytoskeleton Cellular Processes Cell motility FGFR2;EGFR 2 0.11 0.24
32 hsa04918 Thyroid hormone synthesis Organismal Systems Endocrine system HSPA5 1 0.15 0.26
33 hsa03320 PPAR signaling pathway Organismal Systems Endocrine system PPARD 1 0.13 0.26
34 hsa04961 Endocrine and other factor-regulated calcium reabsorption Organismal Systems Excretory system ESR1 1 0.096 0.27
35 hsa05030 Cocaine addiction Human Diseases Substance dependence NFKB1 1 0.1 0.27
36 hsa01524 Platinum drug resistance Human Diseases Drug resistance: Antineoplastic CASP3 1 0.11 0.27
37 hsa05218 Melanoma Human Diseases Cancers: Specific types EGFR 1 0.12 0.27
38 hsa04115 p53 signaling pathway Cellular Processes Cell growth and death CASP3 1 0.092 0.27
39 hsa04610 Complement and coagulation cascades Organismal Systems Immune system C1S 1 0.1 0.27
40 hsa05416 Viral myocarditis Human Diseases Cardiovascular diseases CASP3 1 0.15 0.28
41 hsa04370 VEGF signaling pathway Environmental Information Processing Signal transduction VEGFA 1 0.1 0.28
42 hsa05320 Autoimmune thyroid disease Human Diseases Immune diseases IL2 1 0.19 0.28
43 hsa04662 B cell receptor signaling pathway Organismal Systems Immune system NFKB1 1 0.15 0.28
44 hsa05214 Glioma Human Diseases Cancers: Specific types EGFR 1 0.13 0.28
45 hsa05213 Endometrial cancer Human Diseases Cancers: Specific types EGFR 1 0.16 0.28
46 hsa05223 Non-small cell lung cancer Human Diseases Cancers: Specific types EGFR 1 0.12 0.28
47 hsa05131 Shigellosis Human Diseases Infectious diseases: Bacterial NFKB1 1 0.1 0.28
48 hsa05150 Staphylococcus aureus infection Human Diseases Infectious diseases: Bacterial C1S 1 0.13 0.29
49 hsa04924 Renin secretion Organismal Systems Endocrine system EDNRA 1 0.1 0.29
50 hsa04012 ErbB signaling pathway Environmental Information Processing Signal transduction EGFR 1 0.092 0.29
51 hsa04211 Longevity regulating pathway Organismal Systems Aging NFKB1 1 0.099 0.29
52 hsa04540 Gap junction Cellular Processes Cellular community - eukaryotes EGFR 1 0.11 0.29
53 hsa05211 Renal cell carcinoma Human Diseases Cancers: Specific types VEGFA 1 0.17 0.29
54 hsa04912 GnRH signaling pathway Organismal Systems Endocrine system EGFR 1 0.1 0.29
55 hsa04914 Progesterone-mediated oocyte maturation Organismal Systems Endocrine system PGR 1 0.1 0.29
56 hsa05231 Choline metabolism in cancer Human Diseases Cancers: Overview EGFR 1 0.12 0.29
57 hsa04916 Melanogenesis Organismal Systems Endocrine system EDNRB 1 0.15 0.3
58 hsa04750 Inflammatory mediator regulation of TRP channels Organismal Systems Sensory system IL1B 1 0.11 0.3
59 hsa04928 Parathyroid hormone synthesis, secretion and action Organismal Systems Endocrine system EGFR 1 0.096 0.3
60 hsa04726 Serotonergic synapse Organismal Systems Nervous system CASP3 1 0.14 0.32
61 hsa04919 Thyroid hormone signaling pathway Organismal Systems Endocrine system ESR1 1 0.1 0.32
62 hsa04270 Vascular smooth muscle contraction Organismal Systems Circulatory system EDNRA 1 0.1 0.32
63 hsa04722 Neurotrophin signaling pathway Organismal Systems Nervous system NFKB1 1 0.092 0.32
64 hsa04114 Oocyte meiosis Cellular Processes Cell growth and death PGR 1 0.1 0.32
65 hsa04140 Autophagy - animal Cellular Processes Transport and catabolism HMGB1 1 0.093 0.32
66 hsa04310 Wnt signaling pathway Environmental Information Processing Signal transduction PPARD 1 0.12 0.34
67 hsa04072 Phospholipase D signaling pathway Environmental Information Processing Signal transduction EGFR 1 0.091 0.34
68 hsa04390 Hippo signaling pathway Environmental Information Processing Signal transduction TGFBR2 1 0.13 0.34
69 hsa04934 Cushing syndrome Human Diseases Endocrine and metabolic diseases EGFR 1 0.1 0.34
70 hsa04550 Signaling pathways regulating pluripotency of stem cells Cellular Processes Cellular community - eukaryotes FGFR2 1 0.11 0.34
71 hsa05012 Parkinson disease Human Diseases Neurodegenerative diseases CASP3 1 0.1 0.34
72 hsa04921 Oxytocin signaling pathway Organismal Systems Endocrine system EGFR 1 0.1 0.35
73 hsa04141 Protein processing in endoplasmic reticulum Genetic Information Processing Folding, sorting and degradation HSPA5 1 0.15 0.36
74 hsa04062 Chemokine signaling pathway Organismal Systems Immune system NFKB1 1 0.094 0.39
75 hsa05016 Huntington disease Human Diseases Neurodegenerative diseases CASP3 1 0.093 0.39



  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.