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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
The red circled blue spheres are used for the predicted targets.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB06732


16 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa04919 Thyroid hormone signaling pathway Organismal Systems Endocrine system ESR1 1 0.11 0.073
2 hsa04659 Th17 cell differentiation Organismal Systems Immune system AHR 1 0.15 0.073
3 hsa05204 Chemical carcinogenesis Human Diseases Cancers: Overview CYP1B1 1 0.13 0.074
4 hsa00980 Metabolism of xenobiotics by cytochrome P450 Metabolism Xenobiotics biodegradation and metabolism CYP1B1 1 0.14 0.074
5 hsa05224 Breast cancer Human Diseases Cancers: Specific types ESR1 1 0.12 0.075
6 hsa04934 Cushing syndrome Human Diseases Endocrine and metabolic diseases AHR 1 0.13 0.075
7 hsa01522 Endocrine resistance Human Diseases Drug resistance: Antineoplastic ESR1 1 0.11 0.075
8 hsa04915 Estrogen signaling pathway Organismal Systems Endocrine system ESR1 1 0.13 0.077
9 hsa04917 Prolactin signaling pathway Organismal Systems Endocrine system ESR1 1 0.14 0.081
10 hsa00140 Steroid hormone biosynthesis Metabolism Lipid metabolism CYP1B1 1 0.14 0.089
11 hsa05205 Proteoglycans in cancer Human Diseases Cancers: Overview ESR1 1 0.13 0.09
12 hsa04913 Ovarian steroidogenesis Organismal Systems Endocrine system CYP1B1 1 0.12 0.094
13 hsa04961 Endocrine and other factor-regulated calcium reabsorption Organismal Systems Excretory system ESR1 1 0.12 0.1
14 hsa05206 MicroRNAs in cancer Human Diseases Cancers: Overview CYP1B1 1 0.12 0.12
15 hsa00380 Tryptophan metabolism Metabolism Amino acid metabolism CYP1B1 1 0.17 0.15
16 hsa05200 Pathways in cancer Human Diseases Cancers: Overview ESR1 1 0.25 0.2


34 pathways for predicted targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa04932 Non-alcoholic fatty liver disease (NAFLD) Human Diseases Endocrine and metabolic diseases PPARA 1 0.15 0.29
2 hsa01100 Metabolic pathways Metabolism Global and overview maps HSD17B2;CYP19A1;MT-ATP6;CES1 4 0.27 0.29
3 hsa05012 Parkinson disease Human Diseases Neurodegenerative diseases MT-ATP6 1 0.13 0.29
4 hsa04550 Signaling pathways regulating pluripotency of stem cells Cellular Processes Cellular community - eukaryotes ESRRB 1 0.22 0.29
5 hsa04910 Insulin signaling pathway Organismal Systems Endocrine system PTPN1 1 0.12 0.3
6 hsa00190 Oxidative phosphorylation Metabolism Energy metabolism MT-ATP6 1 0.45 0.31
7 hsa05160 Hepatitis C Human Diseases Infectious diseases: Viral PPARA 1 0.11 0.31
8 hsa05010 Alzheimer disease Human Diseases Neurodegenerative diseases MT-ATP6 1 0.11 0.31
9 hsa04380 Osteoclast differentiation Organismal Systems Development PPARG 1 0.11 0.32
10 hsa03320 PPAR signaling pathway Organismal Systems Endocrine system PPARA;PPARG 2 0.26 0.32
11 hsa04931 Insulin resistance Human Diseases Endocrine and metabolic diseases PPARA;PTPN1 2 0.11 0.32
12 hsa04714 Thermogenesis Organismal Systems Environmental adaptation MT-ATP6;PPARG 2 0.15 0.32
13 hsa05216 Thyroid cancer Human Diseases Cancers: Specific types PPARG 1 0.35 0.32
14 hsa04114 Oocyte meiosis Cellular Processes Cell growth and death PGR 1 0.11 0.32
15 hsa04152 AMPK signaling pathway Environmental Information Processing Signal transduction PPARG 1 0.12 0.33
16 hsa04668 TNF signaling pathway Environmental Information Processing Signal transduction MMP3 1 0.13 0.33
17 hsa04725 Cholinergic synapse Organismal Systems Nervous system CHRM1 1 0.11 0.33
18 hsa04024 cAMP signaling pathway Environmental Information Processing Signal transduction PPARA;CHRM1 2 0.19 0.33
19 hsa05016 Huntington disease Human Diseases Neurodegenerative diseases MT-ATP6;PPARG 2 0.15 0.33
20 hsa04914 Progesterone-mediated oocyte maturation Organismal Systems Endocrine system PGR 1 0.11 0.34
21 hsa04922 Glucagon signaling pathway Organismal Systems Endocrine system PPARA 1 0.15 0.34
22 hsa05215 Prostate cancer Human Diseases Cancers: Specific types MMP3 1 0.13 0.34
23 hsa04657 IL-17 signaling pathway Organismal Systems Immune system MMP3 1 0.11 0.36
24 hsa04810 Regulation of actin cytoskeleton Cellular Processes Cell motility CHRM1 1 0.12 0.36
25 hsa05323 Rheumatoid arthritis Human Diseases Immune diseases MMP3 1 0.17 0.36
26 hsa04211 Longevity regulating pathway Organismal Systems Aging PPARG 1 0.17 0.38
27 hsa05202 Transcriptional misregulation in cancer Human Diseases Cancers: Overview MMP3;PPARG 2 0.14 0.38
28 hsa00983 Drug metabolism - other enzymes Metabolism Xenobiotics biodegradation and metabolism CES1 1 0.29 0.39
29 hsa04971 Gastric acid secretion Organismal Systems Digestive system HRH2 1 0.15 0.39
30 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction HRH2;CHRM1 2 0.27 0.4
31 hsa04520 Adherens junction Cellular Processes Cellular community - eukaryotes PTPN1 1 0.15 0.4
32 hsa04920 Adipocytokine signaling pathway Organismal Systems Endocrine system PPARA 1 0.19 0.42
33 hsa04020 Calcium signaling pathway Environmental Information Processing Signal transduction HRH2;CHRM1 2 0.19 0.44
34 hsa04151 PI3K-Akt signaling pathway Environmental Information Processing Signal transduction CHRM1 1 0.19 0.52


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.