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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
The red circled blue spheres are used for the predicted targets.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB13873


17 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa03320 PPAR signaling pathway Organismal Systems Endocrine system PPARA;PPARD;PPARG 3 0.19 1.6E-5
2 hsa04310 Wnt signaling pathway Environmental Information Processing Signal transduction PPARD 1 0.16 0.077
3 hsa04932 Non-alcoholic fatty liver disease (NAFLD) Human Diseases Endocrine and metabolic diseases PPARA 1 0.1 0.077
4 hsa04380 Osteoclast differentiation Organismal Systems Development PPARG 1 0.088 0.08
5 hsa05160 Hepatitis C Human Diseases Infectious diseases: Viral PPARA 1 0.089 0.08
6 hsa04024 cAMP signaling pathway Environmental Information Processing Signal transduction PPARA 1 0.19 0.082
7 hsa05016 Huntington disease Human Diseases Neurodegenerative diseases PPARG 1 0.095 0.082
8 hsa05216 Thyroid cancer Human Diseases Cancers: Specific types PPARG 1 0.29 0.084
9 hsa05200 Pathways in cancer Human Diseases Cancers: Overview PPARD;PPARG 2 0.25 0.084
10 hsa05202 Transcriptional misregulation in cancer Human Diseases Cancers: Overview PPARG 1 0.094 0.086
11 hsa04152 AMPK signaling pathway Environmental Information Processing Signal transduction PPARG 1 0.089 0.086
12 hsa04714 Thermogenesis Organismal Systems Environmental adaptation PPARG 1 0.1 0.089
13 hsa04931 Insulin resistance Human Diseases Endocrine and metabolic diseases PPARA 1 0.088 0.09
14 hsa04922 Glucagon signaling pathway Organismal Systems Endocrine system PPARA 1 0.095 0.09
15 hsa05221 Acute myeloid leukemia Human Diseases Cancers: Specific types PPARD 1 0.12 0.093
16 hsa04920 Adipocytokine signaling pathway Organismal Systems Endocrine system PPARA 1 0.14 0.093
17 hsa04211 Longevity regulating pathway Organismal Systems Aging PPARG 1 0.11 0.099


105 pathways for predicted targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa04919 Thyroid hormone signaling pathway Organismal Systems Endocrine system NCOA2;AKT1;NCOA1;RXRA;ESR1;RXRG 6 0.11 1.4E-5
2 hsa04915 Estrogen signaling pathway Organismal Systems Endocrine system NCOA2;PGR;AKT1;NCOA1;ESR2;ESR1 6 0.13 1.9E-5
3 hsa05224 Breast cancer Human Diseases Cancers: Specific types ESR1;PGR;AKT1;NCOA1;ESR2 5 0.12 0.00049
4 hsa05222 Small cell lung cancer Human Diseases Cancers: Specific types PTGS2;AKT1;RXRA;RXRG 4 0.12 0.0012
5 hsa04923 Regulation of lipolysis in adipocytes Organismal Systems Endocrine system PTGS2;AKT1;PTGS1 3 0.12 0.0047
6 hsa00590 Arachidonic acid metabolism Metabolism Lipid metabolism CBR1;PTGS2;PTGS1 3 0.14 0.0062
7 hsa05223 Non-small cell lung cancer Human Diseases Cancers: Specific types AKT1;RXRA;RXRG 3 0.2 0.0062
8 hsa04917 Prolactin signaling pathway Organismal Systems Endocrine system ESR1;AKT1;ESR2 3 0.12 0.0064
9 hsa01522 Endocrine resistance Human Diseases Drug resistance: Antineoplastic ESR1;AKT1;ESR2 3 0.11 0.015
10 hsa04910 Insulin signaling pathway Organismal Systems Endocrine system AKT1;SREBF1;PTPN1 3 0.13 0.036
11 hsa04261 Adrenergic signaling in cardiomyocytes Organismal Systems Circulatory system ADRA1B;AKT1;SCN5A 3 0.12 0.037
12 hsa05226 Gastric cancer Human Diseases Cancers: Specific types AKT1;RXRA;RXRG 3 0.12 0.038
13 hsa04370 VEGF signaling pathway Environmental Information Processing Signal transduction PTGS2;AKT1 2 0.13 0.062
14 hsa05204 Chemical carcinogenesis Human Diseases Cancers: Overview CBR1;PTGS2 2 0.18 0.11
15 hsa04659 Th17 cell differentiation Organismal Systems Immune system RXRA;RXRG 2 0.13 0.12
16 hsa04928 Parathyroid hormone synthesis, secretion and action Organismal Systems Endocrine system RXRA;RXRG 2 0.14 0.12
17 hsa04668 TNF signaling pathway Environmental Information Processing Signal transduction PTGS2;AKT1 2 0.14 0.12
18 hsa04625 C-type lectin receptor signaling pathway Organismal Systems Immune system PTGS2;AKT1 2 0.12 0.12
19 hsa04726 Serotonergic synapse Organismal Systems Nervous system PTGS2;PTGS1 2 0.14 0.13
20 hsa05142 Chagas disease (American trypanosomiasis) Human Diseases Infectious diseases: Parasitic AKT1;SERPINE1 2 0.13 0.13
21 hsa00061 Fatty acid biosynthesis Metabolism Lipid metabolism ACSL4 1 0.27 0.13
22 hsa04066 HIF-1 signaling pathway Environmental Information Processing Signal transduction AKT1;SERPINE1 2 0.13 0.13
23 hsa04611 Platelet activation Organismal Systems Immune system AKT1;PTGS1 2 0.11 0.13
24 hsa04933 AGE-RAGE signaling pathway in diabetic complications Human Diseases Endocrine and metabolic diseases AKT1;SERPINE1 2 0.12 0.13
25 hsa04914 Progesterone-mediated oocyte maturation Organismal Systems Endocrine system PGR;AKT1 2 0.11 0.14
26 hsa04371 Apelin signaling pathway Environmental Information Processing Signal transduction AKT1;SERPINE1 2 0.14 0.15
27 hsa04022 cGMP-PKG signaling pathway Environmental Information Processing Signal transduction ADRA1B;AKT1 2 0.13 0.19
28 hsa04218 Cellular senescence Cellular Processes Cell growth and death AKT1;SERPINE1 2 0.11 0.19
29 hsa00790 Folate biosynthesis Metabolism Metabolism of cofactors and vitamins CBR1 1 0.29 0.21
30 hsa05167 Kaposi sarcoma-associated herpesvirus infection Human Diseases Infectious diseases: Viral PTGS2;AKT1 2 0.11 0.23
31 hsa05205 Proteoglycans in cancer Human Diseases Cancers: Overview ESR1;AKT1 2 0.13 0.25
32 hsa04216 Ferroptosis Cellular Processes Cell growth and death ACSL4 1 0.31 0.29
33 hsa04973 Carbohydrate digestion and absorption Organismal Systems Digestive system AKT1 1 0.33 0.29
34 hsa00071 Fatty acid degradation Metabolism Lipid metabolism ACSL4 1 0.31 0.29
35 hsa05163 Human cytomegalovirus infection 0 0 PTGS2;AKT1 2 0.12 0.29
36 hsa04913 Ovarian steroidogenesis Organismal Systems Endocrine system PTGS2 1 0.16 0.29
37 hsa01212 Fatty acid metabolism Metabolism Global and overview maps ACSL4 1 0.34 0.29
38 hsa04961 Endocrine and other factor-regulated calcium reabsorption Organismal Systems Excretory system ESR1 1 0.17 0.29
39 hsa04610 Complement and coagulation cascades Organismal Systems Immune system SERPINE1 1 0.14 0.31
40 hsa01521 EGFR tyrosine kinase inhibitor resistance Human Diseases Drug resistance: Antineoplastic AKT1 1 0.14 0.31
41 hsa00980 Metabolism of xenobiotics by cytochrome P450 Metabolism Xenobiotics biodegradation and metabolism CBR1 1 0.25 0.31
42 hsa05220 Chronic myeloid leukemia Human Diseases Cancers: Specific types AKT1 1 0.22 0.31
43 hsa05165 Human papillomavirus infection Human Diseases Infectious diseases: Viral PTGS2;AKT1 2 0.13 0.31
44 hsa05210 Colorectal cancer Human Diseases Cancers: Specific types AKT1 1 0.17 0.31
45 hsa04657 IL-17 signaling pathway Organismal Systems Immune system PTGS2 1 0.12 0.32
46 hsa04151 PI3K-Akt signaling pathway Environmental Information Processing Signal transduction AKT1;RXRA 2 0.17 0.32
47 hsa04064 NF-kappa B signaling pathway Environmental Information Processing Signal transduction PTGS2 1 0.13 0.32
48 hsa05212 Pancreatic cancer Human Diseases Cancers: Specific types AKT1 1 0.16 0.32
49 hsa05215 Prostate cancer Human Diseases Cancers: Specific types AKT1 1 0.12 0.32
50 hsa04012 ErbB signaling pathway Environmental Information Processing Signal transduction AKT1 1 0.16 0.32
51 hsa05231 Choline metabolism in cancer Human Diseases Cancers: Overview AKT1 1 0.21 0.32
52 hsa05140 Leishmaniasis Human Diseases Infectious diseases: Parasitic PTGS2 1 0.14 0.32
53 hsa04970 Salivary secretion Organismal Systems Digestive system ADRA1B 1 0.12 0.32
54 hsa04666 Fc gamma R-mediated phagocytosis Organismal Systems Immune system AKT1 1 0.26 0.32
55 hsa04146 Peroxisome Cellular Processes Transport and catabolism ACSL4 1 0.29 0.32
56 hsa04660 T cell receptor signaling pathway Organismal Systems Immune system AKT1 1 0.14 0.32
57 hsa01524 Platinum drug resistance Human Diseases Drug resistance: Antineoplastic AKT1 1 0.19 0.32
58 hsa04620 Toll-like receptor signaling pathway Organismal Systems Immune system AKT1 1 0.13 0.32
59 hsa04520 Adherens junction Cellular Processes Cellular community - eukaryotes PTPN1 1 0.15 0.32
60 hsa05218 Melanoma Human Diseases Cancers: Specific types AKT1 1 0.21 0.33
61 hsa04115 p53 signaling pathway Cellular Processes Cell growth and death SERPINE1 1 0.15 0.33
62 hsa05213 Endometrial cancer Human Diseases Cancers: Specific types AKT1 1 0.24 0.33
63 hsa05145 Toxoplasmosis Human Diseases Infectious diseases: Parasitic AKT1 1 0.14 0.34
64 hsa04725 Cholinergic synapse Organismal Systems Nervous system AKT1 1 0.11 0.34
65 hsa04976 Bile secretion Organismal Systems Digestive system RXRA 1 0.14 0.34
66 hsa05214 Glioma Human Diseases Cancers: Specific types AKT1 1 0.22 0.34
67 hsa05162 Measles Human Diseases Infectious diseases: Viral AKT1 1 0.12 0.34
68 hsa04068 FoxO signaling pathway Environmental Information Processing Signal transduction AKT1 1 0.12 0.34
69 hsa04071 Sphingolipid signaling pathway Environmental Information Processing Signal transduction AKT1 1 0.13 0.34
70 hsa04722 Neurotrophin signaling pathway Organismal Systems Nervous system AKT1 1 0.14 0.34
71 hsa04270 Vascular smooth muscle contraction Organismal Systems Circulatory system ADRA1B 1 0.12 0.34
72 hsa05418 Fluid shear stress and atherosclerosis Human Diseases Cardiovascular diseases AKT1 1 0.11 0.35
73 hsa04550 Signaling pathways regulating pluripotency of stem cells Cellular Processes Cellular community - eukaryotes AKT1 1 0.19 0.35
74 hsa04114 Oocyte meiosis Cellular Processes Cell growth and death PGR 1 0.12 0.35
75 hsa04213 Longevity regulating pathway - multiple species Organismal Systems Aging AKT1 1 0.24 0.35
76 hsa04728 Dopaminergic synapse Organismal Systems Nervous system AKT1 1 0.12 0.35
77 hsa04210 Apoptosis Cellular Processes Cell growth and death AKT1 1 0.14 0.35
78 hsa04926 Relaxin signaling pathway Organismal Systems Endocrine system AKT1 1 0.11 0.35
79 hsa04662 B cell receptor signaling pathway Organismal Systems Immune system AKT1 1 0.23 0.35
80 hsa04140 Autophagy - animal Cellular Processes Transport and catabolism AKT1 1 0.16 0.35
81 hsa04921 Oxytocin signaling pathway Organismal Systems Endocrine system PTGS2 1 0.11 0.35
82 hsa04390 Hippo signaling pathway Environmental Information Processing Signal transduction SERPINE1 1 0.32 0.35
83 hsa04150 mTOR signaling pathway Environmental Information Processing Signal transduction AKT1 1 0.16 0.35
84 hsa04072 Phospholipase D signaling pathway Environmental Information Processing Signal transduction AKT1 1 0.15 0.35
85 hsa04723 Retrograde endocannabinoid signaling Organismal Systems Nervous system PTGS2 1 0.11 0.35
86 hsa05161 Hepatitis B Human Diseases Infectious diseases: Viral AKT1 1 0.11 0.35
87 hsa05230 Central carbon metabolism in cancer Human Diseases Cancers: Overview AKT1 1 0.19 0.35
88 hsa04664 Fc epsilon RI signaling pathway Organismal Systems Immune system AKT1 1 0.15 0.36
89 hsa05211 Renal cell carcinoma Human Diseases Cancers: Specific types AKT1 1 0.25 0.36
90 hsa04630 JAK-STAT signaling pathway Environmental Information Processing Signal transduction AKT1 1 0.15 0.36
91 hsa05225 Hepatocellular carcinoma Human Diseases Cancers: Specific types AKT1 1 0.14 0.37
92 hsa05164 Influenza A Human Diseases Infectious diseases: Viral AKT1 1 0.11 0.37
93 hsa05152 Tuberculosis Human Diseases Infectious diseases: Bacterial AKT1 1 0.11 0.38
94 hsa01100 Metabolic pathways Metabolism Global and overview maps CBR1;ACSL4;PTGS2;PTGS1 4 0.27 0.38
95 hsa04020 Calcium signaling pathway Environmental Information Processing Signal transduction ADRA1B 1 0.18 0.38
96 hsa04062 Chemokine signaling pathway Organismal Systems Immune system AKT1 1 0.14 0.39
97 hsa05169 Epstein-Barr virus infection Human Diseases Infectious diseases: Viral AKT1 1 0.11 0.4
98 hsa04510 Focal adhesion Cellular Processes Cellular community - eukaryotes AKT1 1 0.12 0.4
99 hsa04015 Rap1 signaling pathway Environmental Information Processing Signal transduction AKT1 1 0.12 0.4
100 hsa05170 Human immunodeficiency virus 1 infection 0 0 AKT1 1 0.13 0.41
101 hsa04014 Ras signaling pathway Environmental Information Processing Signal transduction AKT1 1 0.11 0.43
102 hsa05166 Human T-cell leukemia virus 1 infection Human Diseases Infectious diseases: Viral AKT1 1 0.12 0.46
103 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction ADRA1B 1 0.27 0.48
104 hsa05206 MicroRNAs in cancer Human Diseases Cancers: Overview PTGS2 1 0.11 0.5
105 hsa04010 MAPK signaling pathway Environmental Information Processing Signal transduction AKT1 1 0.12 0.5


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.