QuartataWeb
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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB13873


17 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa03320 PPAR signaling pathway Organismal Systems Endocrine system PPARA;PPARD;PPARG 3 0.19 1.6E-5
2 hsa04310 Wnt signaling pathway Environmental Information Processing Signal transduction PPARD 1 0.16 0.077
3 hsa04932 Non-alcoholic fatty liver disease (NAFLD) Human Diseases Endocrine and metabolic diseases PPARA 1 0.1 0.077
4 hsa04380 Osteoclast differentiation Organismal Systems Development PPARG 1 0.088 0.08
5 hsa05160 Hepatitis C Human Diseases Infectious diseases: Viral PPARA 1 0.089 0.08
6 hsa04024 cAMP signaling pathway Environmental Information Processing Signal transduction PPARA 1 0.19 0.082
7 hsa05016 Huntington disease Human Diseases Neurodegenerative diseases PPARG 1 0.095 0.082
8 hsa05216 Thyroid cancer Human Diseases Cancers: Specific types PPARG 1 0.29 0.084
9 hsa05200 Pathways in cancer Human Diseases Cancers: Overview PPARD;PPARG 2 0.25 0.084
10 hsa05202 Transcriptional misregulation in cancer Human Diseases Cancers: Overview PPARG 1 0.094 0.086
11 hsa04152 AMPK signaling pathway Environmental Information Processing Signal transduction PPARG 1 0.089 0.086
12 hsa04714 Thermogenesis Organismal Systems Environmental adaptation PPARG 1 0.1 0.089
13 hsa04931 Insulin resistance Human Diseases Endocrine and metabolic diseases PPARA 1 0.088 0.09
14 hsa04922 Glucagon signaling pathway Organismal Systems Endocrine system PPARA 1 0.095 0.09
15 hsa05221 Acute myeloid leukemia Human Diseases Cancers: Specific types PPARD 1 0.12 0.093
16 hsa04920 Adipocytokine signaling pathway Organismal Systems Endocrine system PPARA 1 0.14 0.093
17 hsa04211 Longevity regulating pathway Organismal Systems Aging PPARG 1 0.11 0.099


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.