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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
The red circled blue spheres are used for the predicted targets.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB07863


21 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa05216 Thyroid cancer Human Diseases Cancers: Specific types PPARG;RXRA 2 0.36 0.0015
2 hsa03320 PPAR signaling pathway Organismal Systems Endocrine system PPARG;RXRA 2 0.26 0.003
3 hsa04919 Thyroid hormone signaling pathway Organismal Systems Endocrine system NCOA2;RXRA 2 0.1 0.005
4 hsa05202 Transcriptional misregulation in cancer Human Diseases Cancers: Overview PPARG;RXRA 2 0.12 0.0096
5 hsa05200 Pathways in cancer Human Diseases Cancers: Overview PPARG;RXRA 2 0.25 0.059
6 hsa05226 Gastric cancer Human Diseases Cancers: Specific types RXRA 1 0.096 0.068
7 hsa04932 Non-alcoholic fatty liver disease (NAFLD) Human Diseases Endocrine and metabolic diseases RXRA 1 0.13 0.068
8 hsa04915 Estrogen signaling pathway Organismal Systems Endocrine system NCOA2 1 0.13 0.071
9 hsa05160 Hepatitis C Human Diseases Infectious diseases: Viral RXRA 1 0.1 0.071
10 hsa04380 Osteoclast differentiation Organismal Systems Development PPARG 1 0.096 0.072
11 hsa04659 Th17 cell differentiation Organismal Systems Immune system RXRA 1 0.1 0.074
12 hsa04928 Parathyroid hormone synthesis, secretion and action Organismal Systems Endocrine system RXRA 1 0.13 0.074
13 hsa04920 Adipocytokine signaling pathway Organismal Systems Endocrine system RXRA 1 0.17 0.074
14 hsa04976 Bile secretion Organismal Systems Digestive system RXRA 1 0.14 0.074
15 hsa04152 AMPK signaling pathway Environmental Information Processing Signal transduction PPARG 1 0.11 0.076
16 hsa05222 Small cell lung cancer Human Diseases Cancers: Specific types RXRA 1 0.098 0.077
17 hsa04211 Longevity regulating pathway Organismal Systems Aging PPARG 1 0.16 0.077
18 hsa05223 Non-small cell lung cancer Human Diseases Cancers: Specific types RXRA 1 0.2 0.082
19 hsa05016 Huntington disease Human Diseases Neurodegenerative diseases PPARG 1 0.16 0.083
20 hsa04714 Thermogenesis Organismal Systems Environmental adaptation PPARG 1 0.12 0.094
21 hsa04151 PI3K-Akt signaling pathway Environmental Information Processing Signal transduction RXRA 1 0.18 0.14


31 pathways for predicted targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa04931 Insulin resistance Human Diseases Endocrine and metabolic diseases PPARA;NR1H3;SREBF1 3 0.1 0.026
2 hsa01522 Endocrine resistance Human Diseases Drug resistance: Antineoplastic ESR1;GPER1;ESR2 3 0.11 0.026
3 hsa05224 Breast cancer Human Diseases Cancers: Specific types ESR1;NCOA1;ESR2 3 0.1 0.038
4 hsa04961 Endocrine and other factor-regulated calcium reabsorption Organismal Systems Excretory system ESR1;VDR 2 0.084 0.038
5 hsa04917 Prolactin signaling pathway Organismal Systems Endocrine system ESR1;ESR2 2 0.1 0.067
6 hsa00061 Fatty acid biosynthesis Metabolism Lipid metabolism ACSL4 1 0.079 0.15
7 hsa04913 Ovarian steroidogenesis Organismal Systems Endocrine system CYP1B1 1 0.079 0.24
8 hsa04978 Mineral absorption Organismal Systems Digestive system VDR 1 0.072 0.24
9 hsa01212 Fatty acid metabolism Metabolism Global and overview maps ACSL4 1 0.1 0.25
10 hsa00140 Steroid hormone biosynthesis Metabolism Lipid metabolism CYP1B1 1 0.076 0.26
11 hsa04930 Type II diabetes mellitus Human Diseases Endocrine and metabolic diseases ABCC8 1 0.076 0.27
12 hsa05221 Acute myeloid leukemia Human Diseases Cancers: Specific types PPARD 1 0.09 0.27
13 hsa04911 Insulin secretion Organismal Systems Endocrine system ABCC8 1 0.083 0.27
14 hsa04146 Peroxisome Cellular Processes Transport and catabolism ACSL4 1 0.076 0.27
15 hsa00071 Fatty acid degradation Metabolism Lipid metabolism ACSL4 1 0.072 0.28
16 hsa05204 Chemical carcinogenesis Human Diseases Cancers: Overview CYP1B1 1 0.084 0.28
17 hsa00240 Pyrimidine metabolism Metabolism Nucleotide metabolism DHODH 1 0.08 0.28
18 hsa04922 Glucagon signaling pathway Organismal Systems Endocrine system PPARA 1 0.076 0.28
19 hsa00980 Metabolism of xenobiotics by cytochrome P450 Metabolism Xenobiotics biodegradation and metabolism CYP1B1 1 0.08 0.29
20 hsa05215 Prostate cancer Human Diseases Cancers: Specific types AR 1 0.12 0.29
21 hsa02010 ABC transporters Environmental Information Processing Membrane transport ABCC8 1 0.073 0.3
22 hsa04114 Oocyte meiosis Cellular Processes Cell growth and death AR 1 0.1 0.32
23 hsa00380 Tryptophan metabolism Metabolism Amino acid metabolism CYP1B1 1 0.081 0.33
24 hsa04910 Insulin signaling pathway Organismal Systems Endocrine system SREBF1 1 0.1 0.34
25 hsa04216 Ferroptosis Cellular Processes Cell growth and death ACSL4 1 0.083 0.34
26 hsa04310 Wnt signaling pathway Environmental Information Processing Signal transduction PPARD 1 0.088 0.34
27 hsa05152 Tuberculosis Human Diseases Infectious diseases: Bacterial VDR 1 0.099 0.39
28 hsa04024 cAMP signaling pathway Environmental Information Processing Signal transduction PPARA 1 0.18 0.4
29 hsa05205 Proteoglycans in cancer Human Diseases Cancers: Overview ESR1 1 0.13 0.4
30 hsa05206 MicroRNAs in cancer Human Diseases Cancers: Overview CYP1B1 1 0.099 0.52
31 hsa01100 Metabolic pathways Metabolism Global and overview maps DHODH;ACSL4 2 0.27 0.82


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.