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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
The red circled blue spheres are used for the predicted targets.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB09285


25 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa04913 Ovarian steroidogenesis Organismal Systems Endocrine system ALOX5;PTGS2 2 0.4 0.0052
2 hsa00590 Arachidonic acid metabolism Metabolism Lipid metabolism ALOX5;PTGS2 2 0.29 0.0052
3 hsa04726 Serotonergic synapse Organismal Systems Nervous system ALOX5;PTGS2 2 0.16 0.012
4 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction LTB4R;TBXA2R 2 0.27 0.049
5 hsa04668 TNF signaling pathway Environmental Information Processing Signal transduction PTGS2 1 0.19 0.099
6 hsa05145 Toxoplasmosis Human Diseases Infectious diseases: Parasitic ALOX5 1 0.21 0.099
7 hsa04611 Platelet activation Organismal Systems Immune system TBXA2R 1 0.13 0.1
8 hsa04625 C-type lectin receptor signaling pathway Organismal Systems Immune system PTGS2 1 0.15 0.1
9 hsa04657 IL-17 signaling pathway Organismal Systems Immune system PTGS2 1 0.15 0.1
10 hsa04064 NF-kappa B signaling pathway Environmental Information Processing Signal transduction PTGS2 1 0.26 0.1
11 hsa04723 Retrograde endocannabinoid signaling Organismal Systems Nervous system PTGS2 1 0.13 0.11
12 hsa04921 Oxytocin signaling pathway Organismal Systems Endocrine system PTGS2 1 0.14 0.11
13 hsa05222 Small cell lung cancer Human Diseases Cancers: Specific types PTGS2 1 0.15 0.11
14 hsa04020 Calcium signaling pathway Environmental Information Processing Signal transduction TBXA2R 1 0.21 0.12
15 hsa05167 Kaposi sarcoma-associated herpesvirus infection Human Diseases Infectious diseases: Viral PTGS2 1 0.13 0.12
16 hsa05140 Leishmaniasis Human Diseases Infectious diseases: Parasitic PTGS2 1 0.24 0.12
17 hsa05204 Chemical carcinogenesis Human Diseases Cancers: Overview PTGS2 1 0.54 0.12
18 hsa04664 Fc epsilon RI signaling pathway Organismal Systems Immune system ALOX5 1 0.32 0.12
19 hsa04370 VEGF signaling pathway Environmental Information Processing Signal transduction PTGS2 1 0.18 0.13
20 hsa04923 Regulation of lipolysis in adipocytes Organismal Systems Endocrine system PTGS2 1 0.16 0.13
21 hsa05163 Human cytomegalovirus infection 0 0 PTGS2 1 0.14 0.14
22 hsa01100 Metabolic pathways Metabolism Global and overview maps ALOX5;PTGS2 2 0.27 0.16
23 hsa05206 MicroRNAs in cancer Human Diseases Cancers: Overview PTGS2 1 0.13 0.16
24 hsa05165 Human papillomavirus infection Human Diseases Infectious diseases: Viral PTGS2 1 0.15 0.18
25 hsa05200 Pathways in cancer Human Diseases Cancers: Overview PTGS2 1 0.27 0.25


139 pathways for predicted targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa01521 EGFR tyrosine kinase inhibitor resistance Human Diseases Drug resistance: Antineoplastic GSK3B;KDR;PRKCA;MET;PRKCB 5 0.11 8.3E-5
2 hsa04151 PI3K-Akt signaling pathway Environmental Information Processing Signal transduction GSK3B;KDR;MET;IKBKB;PPP2CB;CHUK;PRKCA;VWF 8 0.17 8.3E-5
3 hsa04014 Ras signaling pathway Environmental Information Processing Signal transduction KDR;GRIN1;MET;IKBKB;CHUK;PRKCA;PRKCB 7 0.1 0.00011
4 hsa04510 Focal adhesion Cellular Processes Cellular community - eukaryotes GSK3B;KDR;MET;PRKCA;VWF;PRKCB 6 0.097 0.00033
5 hsa04662 B cell receptor signaling pathway Organismal Systems Immune system GSK3B;IKBKB;CHUK;PRKCB 4 0.14 0.00065
6 hsa04310 Wnt signaling pathway Environmental Information Processing Signal transduction GSK3B;CSNK2A1;PPARD;PRKCA;PRKCB 5 0.13 0.00065
7 hsa04150 mTOR signaling pathway Environmental Information Processing Signal transduction GSK3B;IKBKB;PRKCA;PRKCB;CHUK 5 0.11 0.00067
8 hsa05161 Hepatitis B Human Diseases Infectious diseases: Viral CYCS;IKBKB;PRKCA;PRKCB;CHUK 5 0.1 0.00075
9 hsa05164 Influenza A Human Diseases Infectious diseases: Viral CYCS;GSK3B;PRKCA;PRKCB;IKBKB 5 0.1 0.0011
10 hsa04010 MAPK signaling pathway Environmental Information Processing Signal transduction KDR;MET;IKBKB;CHUK;PRKCA;PRKCB 6 0.11 0.0012
11 hsa05205 Proteoglycans in cancer Human Diseases Cancers: Overview ESR1;KDR;PRKCA;MET;PRKCB 5 0.12 0.0019
12 hsa04015 Rap1 signaling pathway Environmental Information Processing Signal transduction PRKCA;KDR;MET;PRKCB;GRIN1 5 0.11 0.0019
13 hsa05170 Human immunodeficiency virus 1 infection 0 0 CYCS;IKBKB;PRKCA;PRKCB;CHUK 5 0.098 0.0021
14 hsa04919 Thyroid hormone signaling pathway Organismal Systems Endocrine system ESR1;GSK3B;PRKCA;PRKCB 4 0.1 0.0022
15 hsa04961 Endocrine and other factor-regulated calcium reabsorption Organismal Systems Excretory system ESR1;PRKCA;PRKCB 3 0.11 0.0023
16 hsa05160 Hepatitis C Human Diseases Infectious diseases: Viral GSK3B;IKBKB;CHUK;PPP2CB 4 0.1 0.0029
17 hsa04728 Dopaminergic synapse Organismal Systems Nervous system GSK3B;PPP2CB;PRKCA;PRKCB 4 0.11 0.0029
18 hsa04730 Long-term depression Organismal Systems Nervous system PPP2CB;PRKCA;PRKCB 3 0.13 0.0039
19 hsa05031 Amphetamine addiction Human Diseases Substance dependence PRKCA;PRKCB;GRIN1 3 0.097 0.0047
20 hsa05120 Epithelial cell signaling in Helicobacter pylori infection Human Diseases Infectious diseases: Bacterial IKBKB;CHUK;MET 3 0.1 0.0047
21 hsa04720 Long-term potentiation Organismal Systems Nervous system PRKCA;PRKCB;GRIN1 3 0.1 0.0049
22 hsa05221 Acute myeloid leukemia Human Diseases Cancers: Specific types IKBKB;PPARD;CHUK 3 0.11 0.0049
23 hsa05225 Hepatocellular carcinoma Human Diseases Cancers: Specific types GSK3B;PRKCA;MET;PRKCB 4 0.097 0.0055
24 hsa05010 Alzheimer disease Human Diseases Neurodegenerative diseases MME;CYCS;GSK3B;GRIN1 4 0.098 0.0056
25 hsa05168 Herpes simplex infection Human Diseases Infectious diseases: Viral CYCS;IKBKB;CHUK;CSNK2A1 4 0.1 0.0072
26 hsa04062 Chemokine signaling pathway Organismal Systems Immune system GSK3B;IKBKB;CHUK;PRKCB 4 0.098 0.0073
27 hsa04012 ErbB signaling pathway Environmental Information Processing Signal transduction GSK3B;PRKCA;PRKCB 3 0.1 0.0073
28 hsa05169 Epstein-Barr virus infection Human Diseases Infectious diseases: Viral GSK3B;IKBKB;CHUK;CSNK2A1 4 0.1 0.0087
29 hsa04713 Circadian entrainment Organismal Systems Environmental adaptation PRKCA;PRKCB;GRIN1 3 0.096 0.0096
30 hsa05215 Prostate cancer Human Diseases Cancers: Specific types GSK3B;IKBKB;CHUK 3 0.12 0.0096
31 hsa04660 T cell receptor signaling pathway Organismal Systems Immune system GSK3B;IKBKB;CHUK 3 0.098 0.01
32 hsa05142 Chagas disease (American trypanosomiasis) Human Diseases Infectious diseases: Parasitic IKBKB;CHUK;PPP2CB 3 0.1 0.01
33 hsa04916 Melanogenesis Organismal Systems Endocrine system GSK3B;PRKCA;PRKCB 3 0.14 0.01
34 hsa04931 Insulin resistance Human Diseases Endocrine and metabolic diseases GSK3B;IKBKB;PRKCB 3 0.096 0.011
35 hsa01523 Antifolate resistance Human Diseases Drug resistance: Antineoplastic IKBKB;CHUK 2 0.14 0.012
36 hsa04724 Glutamatergic synapse Organismal Systems Nervous system PRKCA;PRKCB;GRIN1 3 0.1 0.013
37 hsa04071 Sphingolipid signaling pathway Environmental Information Processing Signal transduction PPP2CB;PRKCA;PRKCB 3 0.099 0.014
38 hsa05143 African trypanosomiasis Human Diseases Infectious diseases: Parasitic PRKCA;PRKCB 2 0.16 0.014
39 hsa04960 Aldosterone-regulated sodium reabsorption Organismal Systems Excretory system PRKCA;PRKCB 2 0.15 0.015
40 hsa05162 Measles Human Diseases Infectious diseases: Viral GSK3B;CSNK2A1;CHUK 3 0.098 0.017
41 hsa04210 Apoptosis Cellular Processes Cell growth and death CYCS;IKBKB;CHUK 3 0.11 0.018
42 hsa05418 Fluid shear stress and atherosclerosis Human Diseases Cardiovascular diseases KDR;CHUK;IKBKB 3 0.1 0.019
43 hsa04932 Non-alcoholic fatty liver disease (NAFLD) Human Diseases Endocrine and metabolic diseases CYCS;GSK3B;IKBKB 3 0.098 0.022
44 hsa05014 Amyotrophic lateral sclerosis (ALS) Human Diseases Neurodegenerative diseases CYCS;GRIN1 2 0.099 0.025
45 hsa04360 Axon guidance Organismal Systems Development GSK3B;PRKCA;MET 3 0.12 0.033
46 hsa04623 Cytosolic DNA-sensing pathway Organismal Systems Immune system IKBKB;CHUK 2 0.23 0.036
47 hsa05131 Shigellosis Human Diseases Infectious diseases: Bacterial IKBKB;CHUK 2 0.11 0.038
48 hsa05223 Non-small cell lung cancer Human Diseases Cancers: Specific types PRKCA;PRKCB 2 0.13 0.038
49 hsa04622 RIG-I-like receptor signaling pathway Organismal Systems Immune system IKBKB;CHUK 2 0.14 0.04
50 hsa04917 Prolactin signaling pathway Organismal Systems Endocrine system ESR1;GSK3B 2 0.097 0.04
51 hsa05214 Glioma Human Diseases Cancers: Specific types PRKCA;PRKCB 2 0.13 0.041
52 hsa04920 Adipocytokine signaling pathway Organismal Systems Endocrine system IKBKB;CHUK 2 0.12 0.041
53 hsa04520 Adherens junction Cellular Processes Cellular community - eukaryotes CSNK2A1;MET 2 0.1 0.041
54 hsa05212 Pancreatic cancer Human Diseases Cancers: Specific types IKBKB;CHUK 2 0.11 0.042
55 hsa04971 Gastric acid secretion Organismal Systems Digestive system PRKCA;PRKCB 2 0.1 0.042
56 hsa05220 Chronic myeloid leukemia Human Diseases Cancers: Specific types IKBKB;CHUK 2 0.14 0.042
57 hsa04918 Thyroid hormone synthesis Organismal Systems Endocrine system PRKCA;PRKCB 2 0.15 0.042
58 hsa04911 Insulin secretion Organismal Systems Endocrine system PRKCA;PRKCB 2 0.098 0.051
59 hsa05210 Colorectal cancer Human Diseases Cancers: Specific types CYCS;GSK3B 2 0.11 0.051
60 hsa05032 Morphine addiction Human Diseases Substance dependence PRKCA;PRKCB 2 0.098 0.052
61 hsa04666 Fc gamma R-mediated phagocytosis Organismal Systems Immune system PRKCA;PRKCB 2 0.16 0.052
62 hsa04540 Gap junction Cellular Processes Cellular community - eukaryotes PRKCA;PRKCB 2 0.1 0.052
63 hsa04727 GABAergic synapse Organismal Systems Nervous system PRKCA;PRKCB 2 0.11 0.052
64 hsa04658 Th1 and Th2 cell differentiation Organismal Systems Immune system IKBKB;CHUK 2 0.11 0.052
65 hsa04912 GnRH signaling pathway Organismal Systems Endocrine system PRKCA;PRKCB 2 0.1 0.052
66 hsa04970 Salivary secretion Organismal Systems Digestive system PRKCA;PRKCB 2 0.098 0.052
67 hsa04974 Protein digestion and absorption Organismal Systems Digestive system MME;DPP4 2 0.098 0.052
68 hsa04972 Pancreatic secretion Organismal Systems Digestive system PRKCA;PRKCB 2 0.1 0.053
69 hsa04925 Aldosterone synthesis and secretion Organismal Systems Endocrine system PRKCA;PRKCB 2 0.12 0.053
70 hsa05231 Choline metabolism in cancer Human Diseases Cancers: Overview PRKCA;PRKCB 2 0.13 0.053
71 hsa04933 AGE-RAGE signaling pathway in diabetic complications Human Diseases Endocrine and metabolic diseases PRKCA;PRKCB 2 0.097 0.053
72 hsa05166 Human T-cell leukemia virus 1 infection Human Diseases Infectious diseases: Viral GSK3B;IKBKB;CHUK 3 0.097 0.053
73 hsa04066 HIF-1 signaling pathway Environmental Information Processing Signal transduction PRKCA;PRKCB 2 0.1 0.053
74 hsa05146 Amoebiasis Human Diseases Infectious diseases: Parasitic PRKCA;PRKCB 2 0.1 0.054
75 hsa04070 Phosphatidylinositol signaling system Environmental Information Processing Signal transduction PRKCA;PRKCB 2 0.21 0.054
76 hsa04750 Inflammatory mediator regulation of TRP channels Organismal Systems Sensory system PRKCA;PRKCB 2 0.1 0.055
77 hsa04620 Toll-like receptor signaling pathway Organismal Systems Immune system IKBKB;CHUK 2 0.1 0.056
78 hsa04928 Parathyroid hormone synthesis, secretion and action Organismal Systems Endocrine system PRKCA;PRKCB 2 0.1 0.057
79 hsa04659 Th17 cell differentiation Organismal Systems Immune system IKBKB;CHUK 2 0.1 0.057
80 hsa04670 Leukocyte transendothelial migration Organismal Systems Immune system PRKCA;PRKCB 2 0.15 0.061
81 hsa04725 Cholinergic synapse Organismal Systems Nervous system PRKCA;PRKCB 2 0.1 0.061
82 hsa04722 Neurotrophin signaling pathway Organismal Systems Nervous system GSK3B;IKBKB 2 0.096 0.067
83 hsa04270 Vascular smooth muscle contraction Organismal Systems Circulatory system PRKCA;PRKCB 2 0.098 0.068
84 hsa04380 Osteoclast differentiation Organismal Systems Development IKBKB;CHUK 2 0.096 0.075
85 hsa04650 Natural killer cell mediated cytotoxicity Organismal Systems Immune system PRKCA;PRKCB 2 0.11 0.077
86 hsa04068 FoxO signaling pathway Environmental Information Processing Signal transduction IKBKB;CHUK 2 0.096 0.077
87 hsa04910 Insulin signaling pathway Organismal Systems Endocrine system GSK3B;IKBKB 2 0.1 0.082
88 hsa04261 Adrenergic signaling in cardiomyocytes Organismal Systems Circulatory system PPP2CB;PRKCA 2 0.11 0.088
89 hsa05224 Breast cancer Human Diseases Cancers: Specific types ESR1;GSK3B 2 0.097 0.091
90 hsa04614 Renin-angiotensin system Organismal Systems Endocrine system MME 1 0.16 0.091
91 hsa05226 Gastric cancer Human Diseases Cancers: Specific types GSK3B;MET 2 0.097 0.091
92 hsa04390 Hippo signaling pathway Environmental Information Processing Signal transduction GSK3B;PPP2CB 2 0.21 0.095
93 hsa04621 NOD-like receptor signaling pathway Organismal Systems Immune system IKBKB;CHUK 2 0.1 0.11
94 hsa04136 Autophagy - other Cellular Processes Transport and catabolism PPP2CB 1 0.27 0.12
95 hsa04215 Apoptosis - multiple species Cellular Processes Cell growth and death CYCS 1 0.21 0.12
96 hsa05016 Huntington disease Human Diseases Neurodegenerative diseases CYCS;GRIN1 2 0.1 0.13
97 hsa05033 Nicotine addiction Human Diseases Substance dependence GRIN1 1 0.1 0.15
98 hsa04973 Carbohydrate digestion and absorption Organismal Systems Digestive system PRKCB 1 0.16 0.16
99 hsa04930 Type II diabetes mellitus Human Diseases Endocrine and metabolic diseases IKBKB 1 0.11 0.16
100 hsa04340 Hedgehog signaling pathway Environmental Information Processing Signal transduction GSK3B 1 0.18 0.17
101 hsa05030 Cocaine addiction Human Diseases Substance dependence GRIN1 1 0.096 0.17
102 hsa05144 Malaria Human Diseases Infectious diseases: Parasitic MET 1 0.15 0.17
103 hsa05110 Vibrio cholerae infection Human Diseases Infectious diseases: Bacterial PRKCA 1 0.2 0.17
104 hsa05130 Pathogenic Escherichia coli infection Human Diseases Infectious diseases: Bacterial PRKCA 1 0.17 0.18
105 hsa05134 Legionellosis Human Diseases Infectious diseases: Bacterial CYCS 1 0.15 0.18
106 hsa00140 Steroid hormone biosynthesis Metabolism Lipid metabolism SULT1E1 1 0.16 0.19
107 hsa05416 Viral myocarditis Human Diseases Cardiovascular diseases CYCS 1 0.22 0.19
108 hsa05213 Endometrial cancer Human Diseases Cancers: Specific types GSK3B 1 0.14 0.19
109 hsa05217 Basal cell carcinoma Human Diseases Cancers: Specific types GSK3B 1 0.21 0.2
110 hsa04137 Mitophagy - animal Cellular Processes Transport and catabolism CSNK2A1 1 0.17 0.2
111 hsa05230 Central carbon metabolism in cancer Human Diseases Cancers: Overview MET 1 0.11 0.2
112 hsa05211 Renal cell carcinoma Human Diseases Cancers: Specific types MET 1 0.15 0.21
113 hsa03320 PPAR signaling pathway Organismal Systems Endocrine system PPARD 1 0.13 0.21
114 hsa05100 Bacterial invasion of epithelial cells Human Diseases Infectious diseases: Bacterial MET 1 0.16 0.21
115 hsa04115 p53 signaling pathway Cellular Processes Cell growth and death CYCS 1 0.1 0.21
116 hsa05218 Melanoma Human Diseases Cancers: Specific types MET 1 0.13 0.21
117 hsa01524 Platinum drug resistance Human Diseases Drug resistance: Antineoplastic CYCS 1 0.12 0.22
118 hsa04610 Complement and coagulation cascades Organismal Systems Immune system VWF 1 0.1 0.23
119 hsa04512 ECM-receptor interaction Environmental Information Processing Signaling molecules and interaction VWF 1 0.22 0.23
120 hsa04350 TGF-beta signaling pathway Environmental Information Processing Signal transduction PPP2CB 1 0.16 0.23
121 hsa03015 mRNA surveillance pathway Genetic Information Processing Translation PPP2CB 1 0.27 0.25
122 hsa04640 Hematopoietic cell lineage Organismal Systems Immune system MME 1 0.13 0.26
123 hsa01522 Endocrine resistance Human Diseases Drug resistance: Antineoplastic ESR1 1 0.1 0.26
124 hsa03008 Ribosome biogenesis in eukaryotes Genetic Information Processing Translation CSNK2A1 1 0.24 0.28
125 hsa04152 AMPK signaling pathway Environmental Information Processing Signal transduction PPP2CB 1 0.1 0.31
126 hsa04114 Oocyte meiosis Cellular Processes Cell growth and death PPP2CB 1 0.097 0.31
127 hsa04110 Cell cycle Cellular Processes Cell growth and death GSK3B 1 0.1 0.31
128 hsa04140 Autophagy - animal Cellular Processes Transport and catabolism PPP2CB 1 0.1 0.32
129 hsa04926 Relaxin signaling pathway Organismal Systems Endocrine system PRKCA 1 0.1 0.32
130 hsa04915 Estrogen signaling pathway Organismal Systems Endocrine system ESR1 1 0.12 0.33
131 hsa04550 Signaling pathways regulating pluripotency of stem cells Cellular Processes Cellular community - eukaryotes GSK3B 1 0.12 0.33
132 hsa05012 Parkinson disease Human Diseases Neurodegenerative diseases CYCS 1 0.1 0.34
133 hsa04072 Phospholipase D signaling pathway Environmental Information Processing Signal transduction PRKCA 1 0.1 0.34
134 hsa04934 Cushing syndrome Human Diseases Endocrine and metabolic diseases GSK3B 1 0.096 0.35
135 hsa04530 Tight junction Cellular Processes Cellular community - eukaryotes PPP2CB 1 0.11 0.38
136 hsa05034 Alcoholism Human Diseases Substance dependence GRIN1 1 0.1 0.39
137 hsa05152 Tuberculosis Human Diseases Infectious diseases: Bacterial CYCS 1 0.098 0.39
138 hsa05202 Transcriptional misregulation in cancer Human Diseases Cancers: Overview MET 1 0.11 0.4
139 hsa04024 cAMP signaling pathway Environmental Information Processing Signal transduction GRIN1 1 0.18 0.42


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.