QuartataWeb
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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB09285


25 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa04913 Ovarian steroidogenesis Organismal Systems Endocrine system ALOX5;PTGS2 2 0.4 0.0052
2 hsa00590 Arachidonic acid metabolism Metabolism Lipid metabolism ALOX5;PTGS2 2 0.29 0.0052
3 hsa04726 Serotonergic synapse Organismal Systems Nervous system ALOX5;PTGS2 2 0.16 0.012
4 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction LTB4R;TBXA2R 2 0.27 0.049
5 hsa04668 TNF signaling pathway Environmental Information Processing Signal transduction PTGS2 1 0.19 0.099
6 hsa05145 Toxoplasmosis Human Diseases Infectious diseases: Parasitic ALOX5 1 0.21 0.099
7 hsa04611 Platelet activation Organismal Systems Immune system TBXA2R 1 0.13 0.1
8 hsa04625 C-type lectin receptor signaling pathway Organismal Systems Immune system PTGS2 1 0.15 0.1
9 hsa04657 IL-17 signaling pathway Organismal Systems Immune system PTGS2 1 0.15 0.1
10 hsa04064 NF-kappa B signaling pathway Environmental Information Processing Signal transduction PTGS2 1 0.26 0.1
11 hsa04723 Retrograde endocannabinoid signaling Organismal Systems Nervous system PTGS2 1 0.13 0.11
12 hsa04921 Oxytocin signaling pathway Organismal Systems Endocrine system PTGS2 1 0.14 0.11
13 hsa05222 Small cell lung cancer Human Diseases Cancers: Specific types PTGS2 1 0.15 0.11
14 hsa04020 Calcium signaling pathway Environmental Information Processing Signal transduction TBXA2R 1 0.21 0.12
15 hsa05167 Kaposi sarcoma-associated herpesvirus infection Human Diseases Infectious diseases: Viral PTGS2 1 0.13 0.12
16 hsa05140 Leishmaniasis Human Diseases Infectious diseases: Parasitic PTGS2 1 0.24 0.12
17 hsa05204 Chemical carcinogenesis Human Diseases Cancers: Overview PTGS2 1 0.54 0.12
18 hsa04664 Fc epsilon RI signaling pathway Organismal Systems Immune system ALOX5 1 0.32 0.12
19 hsa04370 VEGF signaling pathway Environmental Information Processing Signal transduction PTGS2 1 0.18 0.13
20 hsa04923 Regulation of lipolysis in adipocytes Organismal Systems Endocrine system PTGS2 1 0.16 0.13
21 hsa05163 Human cytomegalovirus infection 0 0 PTGS2 1 0.14 0.14
22 hsa01100 Metabolic pathways Metabolism Global and overview maps ALOX5;PTGS2 2 0.27 0.16
23 hsa05206 MicroRNAs in cancer Human Diseases Cancers: Overview PTGS2 1 0.13 0.16
24 hsa05165 Human papillomavirus infection Human Diseases Infectious diseases: Viral PTGS2 1 0.15 0.18
25 hsa05200 Pathways in cancer Human Diseases Cancers: Overview PTGS2 1 0.27 0.25


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.