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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
The red circled blue spheres are used for the predicted targets.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB01251


4 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa04930 Type II diabetes mellitus Human Diseases Endocrine and metabolic diseases ABCC8 1 0.068 0.025
2 hsa02010 ABC transporters Environmental Information Processing Membrane transport ABCC8 1 0.043 0.025
3 hsa04911 Insulin secretion Organismal Systems Endocrine system ABCC8 1 0.068 0.03
4 hsa04022 cGMP-PKG signaling pathway Environmental Information Processing Signal transduction KCNJ8 1 0.12 0.043


56 pathways for predicted targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa04726 Serotonergic synapse Organismal Systems Nervous system SLC6A4;HTR3A;HTR1B;KCNJ5;HTR6;HTR7 6 0.15 2.1E-5
2 hsa04971 Gastric acid secretion Organismal Systems Digestive system KCNJ15;CFTR;KCNJ10;KCNJ1 4 0.13 0.0011
3 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction ADRA2C;DRD5;HTR1B;HTR6;HRH1;HTR7 6 0.27 0.0011
4 hsa04020 Calcium signaling pathway Environmental Information Processing Signal transduction HTR6;DRD5;HRH1;NOS3;HTR7 5 0.19 0.0013
5 hsa04024 cAMP signaling pathway Environmental Information Processing Signal transduction HTR1B;DRD5;CFTR;HTR6 4 0.19 0.019
6 hsa04152 AMPK signaling pathway Environmental Information Processing Signal transduction CFTR;CPT1A;PPARG 3 0.13 0.035
7 hsa04921 Oxytocin signaling pathway Organismal Systems Endocrine system KCNJ14;NOS3;KCNJ5 3 0.12 0.058
8 hsa00232 Caffeine metabolism Metabolism Biosynthesis of other secondary metabolites XDH 1 0.17 0.093
9 hsa03320 PPAR signaling pathway Organismal Systems Endocrine system CPT1A;PPARG 2 0.15 0.1
10 hsa04742 Taste transduction Organismal Systems Sensory system HTR3A;HTR1B 2 0.12 0.11
11 hsa04066 HIF-1 signaling pathway Environmental Information Processing Signal transduction NOS3;HMOX1 2 0.12 0.15
12 hsa04931 Insulin resistance Human Diseases Endocrine and metabolic diseases NOS3;CPT1A 2 0.12 0.15
13 hsa05418 Fluid shear stress and atherosclerosis Human Diseases Cardiovascular diseases NOS3;HMOX1 2 0.12 0.19
14 hsa00220 Arginine biosynthesis Metabolism Amino acid metabolism NOS3 1 0.14 0.19
15 hsa04915 Estrogen signaling pathway Organismal Systems Endocrine system NOS3;KCNJ5 2 0.14 0.2
16 hsa04728 Dopaminergic synapse Organismal Systems Nervous system DRD5;KCNJ5 2 0.13 0.2
17 hsa04978 Mineral absorption Organismal Systems Digestive system HMOX1 1 0.13 0.28
18 hsa05110 Vibrio cholerae infection Human Diseases Infectious diseases: Bacterial CFTR 1 0.13 0.28
19 hsa00330 Arginine and proline metabolism Metabolism Amino acid metabolism NOS3 1 0.13 0.28
20 hsa04714 Thermogenesis Organismal Systems Environmental adaptation CPT1A;PPARG 2 0.13 0.29
21 hsa05216 Thyroid cancer Human Diseases Cancers: Specific types PPARG 1 0.14 0.29
22 hsa04960 Aldosterone-regulated sodium reabsorption Organismal Systems Excretory system KCNJ1 1 0.14 0.29
23 hsa00860 Porphyrin and chlorophyll metabolism Metabolism Metabolism of cofactors and vitamins HMOX1 1 0.15 0.3
24 hsa00071 Fatty acid degradation Metabolism Lipid metabolism CPT1A 1 0.13 0.3
25 hsa04216 Ferroptosis Cellular Processes Cell growth and death HMOX1 1 0.13 0.3
26 hsa01212 Fatty acid metabolism Metabolism Global and overview maps CPT1A 1 0.15 0.3
27 hsa04370 VEGF signaling pathway Environmental Information Processing Signal transduction NOS3 1 0.12 0.3
28 hsa04976 Bile secretion Organismal Systems Digestive system CFTR 1 0.12 0.34
29 hsa04920 Adipocytokine signaling pathway Organismal Systems Endocrine system CPT1A 1 0.14 0.34
30 hsa04933 AGE-RAGE signaling pathway in diabetic complications Human Diseases Endocrine and metabolic diseases NOS3 1 0.12 0.35
31 hsa04750 Inflammatory mediator regulation of TRP channels Organismal Systems Sensory system HRH1 1 0.11 0.35
32 hsa04922 Glucagon signaling pathway Organismal Systems Endocrine system CPT1A 1 0.12 0.35
33 hsa04972 Pancreatic secretion Organismal Systems Digestive system CFTR 1 0.12 0.35
34 hsa04925 Aldosterone synthesis and secretion Organismal Systems Endocrine system KCNJ5 1 0.14 0.35
35 hsa00983 Drug metabolism - other enzymes Metabolism Xenobiotics biodegradation and metabolism XDH 1 0.14 0.36
36 hsa04146 Peroxisome Cellular Processes Transport and catabolism XDH 1 0.15 0.36
37 hsa04713 Circadian entrainment Organismal Systems Environmental adaptation KCNJ5 1 0.12 0.37
38 hsa04725 Cholinergic synapse Organismal Systems Nervous system KCNJ14 1 0.11 0.37
39 hsa04211 Longevity regulating pathway Organismal Systems Aging PPARG 1 0.13 0.37
40 hsa05032 Morphine addiction Human Diseases Substance dependence KCNJ5 1 0.12 0.37
41 hsa04071 Sphingolipid signaling pathway Environmental Information Processing Signal transduction NOS3 1 0.12 0.37
42 hsa04611 Platelet activation Organismal Systems Immune system NOS3 1 0.12 0.38
43 hsa04380 Osteoclast differentiation Organismal Systems Development PPARG 1 0.12 0.38
44 hsa04926 Relaxin signaling pathway Organismal Systems Endocrine system NOS3 1 0.12 0.38
45 hsa04371 Apelin signaling pathway Environmental Information Processing Signal transduction NOS3 1 0.12 0.39
46 hsa04723 Retrograde endocannabinoid signaling Organismal Systems Nervous system KCNJ5 1 0.11 0.4
47 hsa04530 Tight junction Cellular Processes Cellular community - eukaryotes CFTR 1 0.13 0.43
48 hsa00230 Purine metabolism Metabolism Nucleotide metabolism XDH 1 0.13 0.43
49 hsa05225 Hepatocellular carcinoma Human Diseases Cancers: Specific types HMOX1 1 0.13 0.43
50 hsa05202 Transcriptional misregulation in cancer Human Diseases Cancers: Overview PPARG 1 0.13 0.44
51 hsa05016 Huntington disease Human Diseases Neurodegenerative diseases PPARG 1 0.12 0.45
52 hsa05200 Pathways in cancer Human Diseases Cancers: Overview HMOX1;PPARG 2 0.26 0.45
53 hsa04014 Ras signaling pathway Environmental Information Processing Signal transduction HTR7 1 0.11 0.49
54 hsa05206 MicroRNAs in cancer Human Diseases Cancers: Overview HMOX1 1 0.12 0.58
55 hsa04151 PI3K-Akt signaling pathway Environmental Information Processing Signal transduction NOS3 1 0.18 0.63
56 hsa01100 Metabolic pathways Metabolism Global and overview maps NOS3;HMOX1;XDH 3 0.27 0.7


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.