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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
The red circled blue spheres are used for the predicted targets.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB01016


29 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa02010 ABC transporters Environmental Information Processing Membrane transport ABCC9;CFTR;ABCA1;ABCB11;ABCC8 5 0.086 2.0E-8
2 hsa04930 Type II diabetes mellitus Human Diseases Endocrine and metabolic diseases KCNJ11;ABCC8 2 0.11 0.015
3 hsa04979 Cholesterol metabolism Organismal Systems Digestive system ABCA1;ABCB11 2 0.1 0.015
4 hsa04976 Bile secretion Organismal Systems Digestive system CFTR;ABCB11 2 0.1 0.022
5 hsa04911 Insulin secretion Organismal Systems Endocrine system KCNJ11;ABCC8 2 0.11 0.025
6 hsa04152 AMPK signaling pathway Environmental Information Processing Signal transduction CFTR;CPT1A 2 0.11 0.041
7 hsa05110 Vibrio cholerae infection Human Diseases Infectious diseases: Bacterial CFTR 1 0.081 0.17
8 hsa01212 Fatty acid metabolism Metabolism Global and overview maps CPT1A 1 0.12 0.17
9 hsa04931 Insulin resistance Human Diseases Endocrine and metabolic diseases CPT1A 1 0.12 0.18
10 hsa04922 Glucagon signaling pathway Organismal Systems Endocrine system CPT1A 1 0.11 0.18
11 hsa01522 Endocrine resistance Human Diseases Drug resistance: Antineoplastic ABCB11 1 0.11 0.18
12 hsa04726 Serotonergic synapse Organismal Systems Nervous system KCNJ5 1 0.14 0.18
13 hsa04972 Pancreatic secretion Organismal Systems Digestive system CFTR 1 0.12 0.18
14 hsa00071 Fatty acid degradation Metabolism Lipid metabolism CPT1A 1 0.081 0.18
15 hsa04925 Aldosterone synthesis and secretion Organismal Systems Endocrine system KCNJ5 1 0.12 0.19
16 hsa04975 Fat digestion and absorption Organismal Systems Digestive system ABCA1 1 0.081 0.19
17 hsa04915 Estrogen signaling pathway Organismal Systems Endocrine system KCNJ5 1 0.13 0.19
18 hsa04728 Dopaminergic synapse Organismal Systems Nervous system KCNJ5 1 0.13 0.19
19 hsa04971 Gastric acid secretion Organismal Systems Digestive system CFTR 1 0.1 0.19
20 hsa03320 PPAR signaling pathway Organismal Systems Endocrine system CPT1A 1 0.14 0.19
21 hsa04921 Oxytocin signaling pathway Organismal Systems Endocrine system KCNJ5 1 0.11 0.2
22 hsa04723 Retrograde endocannabinoid signaling Organismal Systems Nervous system KCNJ5 1 0.11 0.2
23 hsa04713 Circadian entrainment Organismal Systems Environmental adaptation KCNJ5 1 0.1 0.2
24 hsa04022 cGMP-PKG signaling pathway Environmental Information Processing Signal transduction KCNJ8 1 0.13 0.2
25 hsa04530 Tight junction Cellular Processes Cellular community - eukaryotes CFTR 1 0.11 0.2
26 hsa04920 Adipocytokine signaling pathway Organismal Systems Endocrine system CPT1A 1 0.12 0.21
27 hsa05032 Morphine addiction Human Diseases Substance dependence KCNJ5 1 0.11 0.21
28 hsa04024 cAMP signaling pathway Environmental Information Processing Signal transduction CFTR 1 0.18 0.22
29 hsa04714 Thermogenesis Organismal Systems Environmental adaptation CPT1A 1 0.1 0.24


120 pathways for predicted targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction ADRA2A;CHRM5;CHRM4;CHRM2;CHRM1;HTR2C;CHRM3;CHRNA3;HRH1 9 0.27 8.2E-7
2 hsa04725 Cholinergic synapse Organismal Systems Nervous system CHRM2;AKT1;CHRM5;CHRM4;CHRM1;CHRM3;CHRNA3 7 0.11 8.2E-7
3 hsa04020 Calcium signaling pathway Environmental Information Processing Signal transduction CHRM2;CHRM5;CHRM1;HTR2C;CHRM3;HRH1 6 0.19 0.00023
4 hsa04810 Regulation of actin cytoskeleton Cellular Processes Cell motility CHRM3;CHRM2;CHRM4;CHRM1;CHRM5 5 0.11 0.0059
5 hsa04910 Insulin signaling pathway Organismal Systems Endocrine system PYGM;MAPK10;AKT1;PRKAA1 4 0.12 0.0088
6 hsa05418 Fluid shear stress and atherosclerosis Human Diseases Cardiovascular diseases MAPK10;AKT1;ASS1;PRKAA1 4 0.11 0.0088
7 hsa04750 Inflammatory mediator regulation of TRP channels Organismal Systems Sensory system MAPK10;HRH1;HTR2C 3 0.11 0.037
8 hsa04068 FoxO signaling pathway Environmental Information Processing Signal transduction MAPK10;AKT1;PRKAA1 3 0.11 0.059
9 hsa04926 Relaxin signaling pathway Organismal Systems Endocrine system MAPK10;AKT1;MMP1 3 0.11 0.059
10 hsa04140 Autophagy - animal Cellular Processes Transport and catabolism MAPK10;AKT1;PRKAA1 3 0.12 0.063
11 hsa04932 Non-alcoholic fatty liver disease (NAFLD) Human Diseases Endocrine and metabolic diseases MAPK10;AKT1;PRKAA1 3 0.12 0.075
12 hsa04213 Longevity regulating pathway - multiple species Organismal Systems Aging AKT1;PRKAA1 2 0.2 0.12
13 hsa04664 Fc epsilon RI signaling pathway Organismal Systems Immune system MAPK10;AKT1 2 0.12 0.12
14 hsa04917 Prolactin signaling pathway Organismal Systems Endocrine system MAPK10;AKT1 2 0.11 0.12
15 hsa04151 PI3K-Akt signaling pathway Environmental Information Processing Signal transduction CHRM2;AKT1;CHRM1;PRKAA1 4 0.17 0.12
16 hsa05212 Pancreatic cancer Human Diseases Cancers: Specific types MAPK10;AKT1 2 0.13 0.13
17 hsa05170 Human immunodeficiency virus 1 infection 0 0 CHEK1;MAPK10;AKT1 3 0.11 0.13
18 hsa05210 Colorectal cancer Human Diseases Cancers: Specific types MAPK10;AKT1 2 0.13 0.13
19 hsa04012 ErbB signaling pathway Environmental Information Processing Signal transduction MAPK10;AKT1 2 0.12 0.13
20 hsa04211 Longevity regulating pathway Organismal Systems Aging AKT1;PRKAA1 2 0.13 0.13
21 hsa04620 Toll-like receptor signaling pathway Organismal Systems Immune system MAPK10;AKT1 2 0.12 0.13
22 hsa04625 C-type lectin receptor signaling pathway Organismal Systems Immune system MAPK10;AKT1 2 0.11 0.13
23 hsa05410 Hypertrophic cardiomyopathy (HCM) Human Diseases Cardiovascular diseases CACNG1;PRKAA1 2 0.18 0.13
24 hsa05231 Choline metabolism in cancer Human Diseases Cancers: Overview MAPK10;AKT1 2 0.16 0.14
25 hsa04933 AGE-RAGE signaling pathway in diabetic complications Human Diseases Endocrine and metabolic diseases MAPK10;AKT1 2 0.11 0.14
26 hsa04657 IL-17 signaling pathway Organismal Systems Immune system MAPK10;MMP1 2 0.11 0.14
27 hsa05142 Chagas disease (American trypanosomiasis) Human Diseases Infectious diseases: Parasitic MAPK10;AKT1 2 0.11 0.14
28 hsa04914 Progesterone-mediated oocyte maturation Organismal Systems Endocrine system MAPK10;AKT1 2 0.11 0.14
29 hsa04668 TNF signaling pathway Environmental Information Processing Signal transduction MAPK10;AKT1 2 0.12 0.14
30 hsa05145 Toxoplasmosis Human Diseases Infectious diseases: Parasitic MAPK10;AKT1 2 0.12 0.14
31 hsa04071 Sphingolipid signaling pathway Environmental Information Processing Signal transduction MAPK10;AKT1 2 0.11 0.15
32 hsa04722 Neurotrophin signaling pathway Organismal Systems Nervous system MAPK10;AKT1 2 0.12 0.15
33 hsa04010 MAPK signaling pathway Environmental Information Processing Signal transduction CACNG1;MAPK10;AKT1 3 0.12 0.15
34 hsa04380 Osteoclast differentiation Organismal Systems Development MAPK10;AKT1 2 0.11 0.16
35 hsa05160 Hepatitis C Human Diseases Infectious diseases: Viral MAPK10;AKT1 2 0.12 0.16
36 hsa04371 Apelin signaling pathway Environmental Information Processing Signal transduction AKT1;PRKAA1 2 0.12 0.17
37 hsa04210 Apoptosis Cellular Processes Cell growth and death MAPK10;AKT1 2 0.12 0.17
38 hsa05161 Hepatitis B Human Diseases Infectious diseases: Viral MAPK10;AKT1 2 0.11 0.17
39 hsa04261 Adrenergic signaling in cardiomyocytes Organismal Systems Circulatory system CACNG1;AKT1 2 0.11 0.17
40 hsa00220 Arginine biosynthesis Metabolism Amino acid metabolism ASS1 1 0.23 0.17
41 hsa05226 Gastric cancer Human Diseases Cancers: Specific types ABCB1;AKT1 2 0.11 0.17
42 hsa04150 mTOR signaling pathway Environmental Information Processing Signal transduction AKT1;PRKAA1 2 0.13 0.17
43 hsa04217 Necroptosis Cellular Processes Cell growth and death PYGM;MAPK10 2 0.12 0.19
44 hsa04218 Cellular senescence Cellular Processes Cell growth and death CHEK1;AKT1 2 0.11 0.19
45 hsa05164 Influenza A Human Diseases Infectious diseases: Viral MAPK10;AKT1 2 0.11 0.2
46 hsa04710 Circadian rhythm Organismal Systems Environmental adaptation PRKAA1 1 0.37 0.21
47 hsa05152 Tuberculosis Human Diseases Infectious diseases: Bacterial MAPK10;AKT1 2 0.11 0.21
48 hsa00250 Alanine, aspartate and glutamate metabolism Metabolism Amino acid metabolism ASS1 1 0.5 0.21
49 hsa04062 Chemokine signaling pathway Organismal Systems Immune system AKT1;ADRBK2 2 0.12 0.21
50 hsa04215 Apoptosis - multiple species Cellular Processes Cell growth and death MAPK10 1 0.41 0.21
51 hsa00500 Starch and sucrose metabolism Metabolism Carbohydrate metabolism PYGM 1 0.32 0.21
52 hsa05167 Kaposi sarcoma-associated herpesvirus infection Human Diseases Infectious diseases: Viral MAPK10;AKT1 2 0.11 0.21
53 hsa04960 Aldosterone-regulated sodium reabsorption Organismal Systems Excretory system KCNJ1 1 0.2 0.21
54 hsa05169 Epstein-Barr virus infection Human Diseases Infectious diseases: Viral MAPK10;AKT1 2 0.11 0.22
55 hsa04510 Focal adhesion Cellular Processes Cellular community - eukaryotes MAPK10;AKT1 2 0.11 0.22
56 hsa05219 Bladder cancer Human Diseases Cancers: Specific types MMP1 1 0.16 0.22
57 hsa04973 Carbohydrate digestion and absorption Organismal Systems Digestive system AKT1 1 0.28 0.23
58 hsa04340 Hedgehog signaling pathway Environmental Information Processing Signal transduction ADRBK2 1 0.35 0.25
59 hsa04014 Ras signaling pathway Environmental Information Processing Signal transduction MAPK10;AKT1 2 0.11 0.26
60 hsa04923 Regulation of lipolysis in adipocytes Organismal Systems Endocrine system AKT1 1 0.11 0.27
61 hsa05220 Chronic myeloid leukemia Human Diseases Cancers: Specific types AKT1 1 0.18 0.27
62 hsa05133 Pertussis Human Diseases Infectious diseases: Bacterial MAPK10 1 0.12 0.27
63 hsa01524 Platinum drug resistance Human Diseases Drug resistance: Antineoplastic AKT1 1 0.15 0.27
64 hsa05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) Human Diseases Cardiovascular diseases CACNG1 1 0.34 0.27
65 hsa05218 Melanoma Human Diseases Cancers: Specific types AKT1 1 0.16 0.27
66 hsa01521 EGFR tyrosine kinase inhibitor resistance Human Diseases Drug resistance: Antineoplastic AKT1 1 0.12 0.28
67 hsa04260 Cardiac muscle contraction Organismal Systems Circulatory system CACNG1 1 0.29 0.28
68 hsa01230 Biosynthesis of amino acids Metabolism Global and overview maps ASS1 1 0.26 0.28
69 hsa04115 p53 signaling pathway Cellular Processes Cell growth and death CHEK1 1 0.12 0.28
70 hsa05166 Human T-cell leukemia virus 1 infection Human Diseases Infectious diseases: Viral CHEK1;AKT1 2 0.11 0.28
71 hsa04370 VEGF signaling pathway Environmental Information Processing Signal transduction AKT1 1 0.12 0.28
72 hsa05214 Glioma Human Diseases Cancers: Specific types AKT1 1 0.17 0.28
73 hsa04662 B cell receptor signaling pathway Organismal Systems Immune system AKT1 1 0.19 0.28
74 hsa05221 Acute myeloid leukemia Human Diseases Cancers: Specific types AKT1 1 0.13 0.28
75 hsa05223 Non-small cell lung cancer Human Diseases Cancers: Specific types AKT1 1 0.15 0.28
76 hsa05213 Endometrial cancer Human Diseases Cancers: Specific types AKT1 1 0.19 0.28
77 hsa04622 RIG-I-like receptor signaling pathway Organismal Systems Immune system MAPK10 1 0.19 0.29
78 hsa04912 GnRH signaling pathway Organismal Systems Endocrine system MAPK10 1 0.12 0.29
79 hsa05222 Small cell lung cancer Human Diseases Cancers: Specific types AKT1 1 0.11 0.29
80 hsa05211 Renal cell carcinoma Human Diseases Cancers: Specific types AKT1 1 0.2 0.29
81 hsa04742 Taste transduction Organismal Systems Sensory system CHRM3 1 0.11 0.29
82 hsa05120 Epithelial cell signaling in Helicobacter pylori infection Human Diseases Infectious diseases: Bacterial MAPK10 1 0.12 0.29
83 hsa05200 Pathways in cancer Human Diseases Cancers: Overview MAPK10;AKT1;MMP1 3 0.25 0.29
84 hsa04658 Th1 and Th2 cell differentiation Organismal Systems Immune system MAPK10 1 0.14 0.29
85 hsa04666 Fc gamma R-mediated phagocytosis Organismal Systems Immune system AKT1 1 0.22 0.29
86 hsa05414 Dilated cardiomyopathy (DCM) Human Diseases Cardiovascular diseases CACNG1 1 0.12 0.29
87 hsa05323 Rheumatoid arthritis Human Diseases Immune diseases MMP1 1 0.14 0.29
88 hsa05131 Shigellosis Human Diseases Infectious diseases: Bacterial MAPK10 1 0.13 0.29
89 hsa05230 Central carbon metabolism in cancer Human Diseases Cancers: Overview AKT1 1 0.14 0.29
90 hsa05132 Salmonella infection Human Diseases Infectious diseases: Bacterial MAPK10 1 0.13 0.29
91 hsa04970 Salivary secretion Organismal Systems Digestive system CHRM3 1 0.11 0.29
92 hsa05215 Prostate cancer Human Diseases Cancers: Specific types AKT1 1 0.12 0.29
93 hsa04540 Gap junction Cellular Processes Cellular community - eukaryotes HTR2C 1 0.11 0.29
94 hsa04137 Mitophagy - animal Cellular Processes Transport and catabolism MAPK10 1 0.24 0.3
95 hsa04066 HIF-1 signaling pathway Environmental Information Processing Signal transduction AKT1 1 0.11 0.3
96 hsa04660 T cell receptor signaling pathway Organismal Systems Immune system AKT1 1 0.12 0.3
97 hsa04659 Th17 cell differentiation Organismal Systems Immune system MAPK10 1 0.12 0.31
98 hsa04724 Glutamatergic synapse Organismal Systems Nervous system ADRBK2 1 0.12 0.32
99 hsa04919 Thyroid hormone signaling pathway Organismal Systems Endocrine system AKT1 1 0.11 0.33
100 hsa04110 Cell cycle Cellular Processes Cell growth and death CHEK1 1 0.12 0.34
101 hsa04611 Platelet activation Organismal Systems Immune system AKT1 1 0.11 0.34
102 hsa05162 Measles Human Diseases Infectious diseases: Viral AKT1 1 0.11 0.35
103 hsa04550 Signaling pathways regulating pluripotency of stem cells Cellular Processes Cellular community - eukaryotes AKT1 1 0.15 0.37
104 hsa05224 Breast cancer Human Diseases Cancers: Specific types AKT1 1 0.11 0.37
105 hsa04310 Wnt signaling pathway Environmental Information Processing Signal transduction MAPK10 1 0.16 0.37
106 hsa04072 Phospholipase D signaling pathway Environmental Information Processing Signal transduction AKT1 1 0.12 0.37
107 hsa04630 JAK-STAT signaling pathway Environmental Information Processing Signal transduction AKT1 1 0.12 0.4
108 hsa04621 NOD-like receptor signaling pathway Organismal Systems Immune system MAPK10 1 0.12 0.4
109 hsa05225 Hepatocellular carcinoma Human Diseases Cancers: Specific types AKT1 1 0.12 0.4
110 hsa04141 Protein processing in endoplasmic reticulum Genetic Information Processing Folding, sorting and degradation MAPK10 1 0.2 0.4
111 hsa05168 Herpes simplex infection Human Diseases Infectious diseases: Viral MAPK10 1 0.11 0.43
112 hsa05205 Proteoglycans in cancer Human Diseases Cancers: Overview AKT1 1 0.12 0.45
113 hsa05203 Viral carcinogenesis Human Diseases Cancers: Overview CHEK1 1 0.11 0.45
114 hsa04015 Rap1 signaling pathway Environmental Information Processing Signal transduction AKT1 1 0.11 0.45
115 hsa05163 Human cytomegalovirus infection 0 0 AKT1 1 0.11 0.48
116 hsa04144 Endocytosis Cellular Processes Transport and catabolism ADRBK2 1 0.16 0.5
117 hsa05206 MicroRNAs in cancer Human Diseases Cancers: Overview ABCB1 1 0.11 0.57
118 hsa05165 Human papillomavirus infection Human Diseases Infectious diseases: Viral AKT1 1 0.12 0.62
119 hsa04740 Olfactory transduction Organismal Systems Sensory system ADRBK2 1 0.43 0.72
120 hsa01100 Metabolic pathways Metabolism Global and overview maps PYGM;ASS1 2 0.27 0.88


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.