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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
The red circled blue spheres are used for the predicted targets.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB07231


6 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa04210 Apoptosis Cellular Processes Cell growth and death CTSB 1 0.081 0.022
2 hsa04140 Autophagy - animal Cellular Processes Transport and catabolism CTSB 1 0.089 0.022
3 hsa04621 NOD-like receptor signaling pathway Organismal Systems Immune system CTSB 1 0.069 0.022
4 hsa04142 Lysosome Cellular Processes Transport and catabolism CTSB 1 0.086 0.026
5 hsa04924 Renin secretion Organismal Systems Endocrine system CTSB 1 0.069 0.031
6 hsa04612 Antigen processing and presentation Organismal Systems Immune system CTSB 1 0.086 0.031


113 pathways for predicted targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa00590 Arachidonic acid metabolism Metabolism Lipid metabolism PLA2G1B;ALOX5;PTGS2;TBXAS1;PTGS1 5 0.095 4.4E-5
2 hsa04217 Necroptosis Cellular Processes Cell growth and death PARP3;CASP1;PARP2;PYGL;TNF;PARP1 6 0.1 0.00012
3 hsa03410 Base excision repair Genetic Information Processing Replication and repair PARP3;PARP1;PARP2 3 0.53 0.0027
4 hsa04726 Serotonergic synapse Organismal Systems Nervous system ALOX5;PTGS2;CACNA1A;PTGS1 4 0.14 0.0049
5 hsa05140 Leishmaniasis Human Diseases Infectious diseases: Parasitic TNF;PTGS2;FCGR1A 3 0.1 0.018
6 hsa04064 NF-kappa B signaling pathway Environmental Information Processing Signal transduction TNF;PTGS2;PARP1 3 0.097 0.031
7 hsa01100 Metabolic pathways Metabolism Global and overview maps PNMT;PLA2G1B;PTGS2;PTGS1;TBXAS1;GAA;ALOX5;FPGS;PYGL 9 0.27 0.034
8 hsa04625 C-type lectin receptor signaling pathway Organismal Systems Immune system CASP1;PTGS2;TNF 3 0.097 0.034
9 hsa01523 Antifolate resistance Human Diseases Drug resistance: Antineoplastic TNF;FPGS 2 0.11 0.034
10 hsa00500 Starch and sucrose metabolism Metabolism Carbohydrate metabolism GAA;PYGL 2 0.13 0.041
11 hsa04930 Type II diabetes mellitus Human Diseases Endocrine and metabolic diseases TNF;CACNA1A 2 0.099 0.061
12 hsa04913 Ovarian steroidogenesis Organismal Systems Endocrine system ALOX5;PTGS2 2 0.1 0.063
13 hsa05014 Amyotrophic lateral sclerosis (ALS) Human Diseases Neurodegenerative diseases CASP1;TNF 2 0.096 0.063
14 hsa05134 Legionellosis Human Diseases Infectious diseases: Bacterial CASP1;TNF 2 0.11 0.063
15 hsa04923 Regulation of lipolysis in adipocytes Organismal Systems Endocrine system PTGS2;PTGS1 2 0.097 0.063
16 hsa05416 Viral myocarditis Human Diseases Cardiovascular diseases ABL1;ABL2 2 0.15 0.068
17 hsa04664 Fc epsilon RI signaling pathway Organismal Systems Immune system ALOX5;TNF 2 0.095 0.084
18 hsa05133 Pertussis Human Diseases Infectious diseases: Bacterial CASP1;TNF 2 0.095 0.098
19 hsa04014 Ras signaling pathway Environmental Information Processing Signal transduction ABL1;PLA2G1B;ABL2 3 0.1 0.11
20 hsa04012 ErbB signaling pathway Environmental Information Processing Signal transduction ABL1;ABL2 2 0.1 0.11
21 hsa05204 Chemical carcinogenesis Human Diseases Cancers: Overview GSTA1;PTGS2 2 0.1 0.11
22 hsa04657 IL-17 signaling pathway Organismal Systems Immune system TNF;PTGS2 2 0.099 0.12
23 hsa04640 Hematopoietic cell lineage Organismal Systems Immune system TNF;FCGR1A 2 0.11 0.12
24 hsa04931 Insulin resistance Human Diseases Endocrine and metabolic diseases TNF;PYGL 2 0.098 0.14
25 hsa04668 TNF signaling pathway Environmental Information Processing Signal transduction TNF;PTGS2 2 0.1 0.14
26 hsa05145 Toxoplasmosis Human Diseases Infectious diseases: Parasitic ALOX5;TNF 2 0.1 0.14
27 hsa04611 Platelet activation Organismal Systems Immune system TBXAS1;PTGS1 2 0.098 0.16
28 hsa04380 Osteoclast differentiation Organismal Systems Development TNF;FCGR1A 2 0.1 0.17
29 hsa05322 Systemic lupus erythematosus Human Diseases Immune diseases TNF;FCGR1A 2 0.11 0.17
30 hsa05418 Fluid shear stress and atherosclerosis Human Diseases Cardiovascular diseases GSTA1;TNF 2 0.11 0.18
31 hsa04723 Retrograde endocannabinoid signaling Organismal Systems Nervous system PTGS2;CACNA1A 2 0.1 0.2
32 hsa00592 alpha-Linolenic acid metabolism Metabolism Lipid metabolism PLA2G1B 1 0.29 0.22
33 hsa00790 Folate biosynthesis Metabolism Metabolism of cofactors and vitamins FPGS 1 0.12 0.22
34 hsa05310 Asthma Human Diseases Immune diseases TNF 1 0.2 0.23
35 hsa00052 Galactose metabolism Metabolism Carbohydrate metabolism GAA 1 0.16 0.23
36 hsa05164 Influenza A Human Diseases Infectious diseases: Viral CASP1;TNF 2 0.1 0.23
37 hsa00591 Linoleic acid metabolism Metabolism Lipid metabolism PLA2G1B 1 0.2 0.23
38 hsa05152 Tuberculosis Human Diseases Infectious diseases: Bacterial TNF;FCGR1A 2 0.097 0.23
39 hsa05143 African trypanosomiasis Human Diseases Infectious diseases: Parasitic TNF 1 0.12 0.25
40 hsa00350 Tyrosine metabolism Metabolism Amino acid metabolism PNMT 1 0.12 0.25
41 hsa05330 Allograft rejection Human Diseases Immune diseases TNF 1 0.14 0.25
42 hsa04975 Fat digestion and absorption Organismal Systems Digestive system PLA2G1B 1 0.18 0.26
43 hsa05332 Graft-versus-host disease Human Diseases Immune diseases TNF 1 0.13 0.26
44 hsa04940 Type I diabetes mellitus Human Diseases Endocrine and metabolic diseases TNF 1 0.13 0.26
45 hsa05033 Nicotine addiction Human Diseases Substance dependence CACNA1A 1 0.099 0.26
46 hsa05163 Human cytomegalovirus infection 0 0 TNF;PTGS2 2 0.11 0.27
47 hsa00565 Ether lipid metabolism Metabolism Lipid metabolism PLA2G1B 1 0.26 0.27
48 hsa05144 Malaria Human Diseases Infectious diseases: Parasitic TNF 1 0.12 0.28
49 hsa05150 Staphylococcus aureus infection Human Diseases Infectious diseases: Bacterial FCGR1A 1 0.13 0.3
50 hsa00480 Glutathione metabolism Metabolism Metabolism of other amino acids GSTA1 1 0.12 0.3
51 hsa05221 Acute myeloid leukemia Human Diseases Cancers: Specific types FCGR1A 1 0.11 0.3
52 hsa05321 Inflammatory bowel disease (IBD) Human Diseases Immune diseases TNF 1 0.11 0.3
53 hsa00980 Metabolism of xenobiotics by cytochrome P450 Metabolism Xenobiotics biodegradation and metabolism GSTA1 1 0.11 0.3
54 hsa05220 Chronic myeloid leukemia Human Diseases Cancers: Specific types ABL1 1 0.11 0.3
55 hsa05131 Shigellosis Human Diseases Infectious diseases: Bacterial ABL1 1 0.1 0.3
56 hsa04623 Cytosolic DNA-sensing pathway Organismal Systems Immune system CASP1 1 0.22 0.3
57 hsa04721 Synaptic vesicle cycle Organismal Systems Nervous system CACNA1A 1 0.38 0.3
58 hsa05130 Pathogenic Escherichia coli infection Human Diseases Infectious diseases: Bacterial ABL1 1 0.13 0.3
59 hsa05206 MicroRNAs in cancer Human Diseases Cancers: Overview ABL1;PTGS2 2 0.099 0.3
60 hsa01524 Platinum drug resistance Human Diseases Drug resistance: Antineoplastic GSTA1 1 0.11 0.3
61 hsa04010 MAPK signaling pathway Environmental Information Processing Signal transduction TNF;CACNA1A 2 0.12 0.3
62 hsa04370 VEGF signaling pathway Environmental Information Processing Signal transduction PTGS2 1 0.1 0.3
63 hsa04730 Long-term depression Organismal Systems Nervous system CACNA1A 1 0.11 0.3
64 hsa00564 Glycerophospholipid metabolism Metabolism Lipid metabolism PLA2G1B 1 0.12 0.3
65 hsa04972 Pancreatic secretion Organismal Systems Digestive system PLA2G1B 1 0.1 0.3
66 hsa04622 RIG-I-like receptor signaling pathway Organismal Systems Immune system TNF 1 0.11 0.3
67 hsa04920 Adipocytokine signaling pathway Organismal Systems Endocrine system TNF 1 0.11 0.3
68 hsa05165 Human papillomavirus infection Human Diseases Infectious diseases: Viral TNF;PTGS2 2 0.12 0.3
69 hsa05222 Small cell lung cancer Human Diseases Cancers: Specific types PTGS2 1 0.096 0.3
70 hsa04620 Toll-like receptor signaling pathway Organismal Systems Immune system TNF 1 0.097 0.3
71 hsa04922 Glucagon signaling pathway Organismal Systems Endocrine system PYGL 1 0.097 0.3
72 hsa00983 Drug metabolism - other enzymes Metabolism Xenobiotics biodegradation and metabolism GSTA1 1 0.11 0.3
73 hsa05146 Amoebiasis Human Diseases Infectious diseases: Parasitic TNF 1 0.097 0.3
74 hsa05200 Pathways in cancer Human Diseases Cancers: Overview ABL1;GSTA1;PTGS2 3 0.25 0.3
75 hsa05142 Chagas disease (American trypanosomiasis) Human Diseases Infectious diseases: Parasitic TNF 1 0.1 0.3
76 hsa04933 AGE-RAGE signaling pathway in diabetic complications Human Diseases Endocrine and metabolic diseases TNF 1 0.096 0.31
77 hsa05032 Morphine addiction Human Diseases Substance dependence CACNA1A 1 0.097 0.31
78 hsa04666 Fc gamma R-mediated phagocytosis Organismal Systems Immune system FCGR1A 1 0.12 0.31
79 hsa00982 Drug metabolism - cytochrome P450 Metabolism Xenobiotics biodegradation and metabolism GSTA1 1 0.11 0.31
80 hsa04660 T cell receptor signaling pathway Organismal Systems Immune system TNF 1 0.096 0.31
81 hsa04350 TGF-beta signaling pathway Environmental Information Processing Signal transduction TNF 1 0.13 0.31
82 hsa05410 Hypertrophic cardiomyopathy (HCM) Human Diseases Cardiovascular diseases TNF 1 0.11 0.31
83 hsa04742 Taste transduction Organismal Systems Sensory system CACNA1A 1 0.099 0.31
84 hsa05414 Dilated cardiomyopathy (DCM) Human Diseases Cardiovascular diseases TNF 1 0.096 0.31
85 hsa05323 Rheumatoid arthritis Human Diseases Immune diseases TNF 1 0.11 0.31
86 hsa05132 Salmonella infection Human Diseases Infectious diseases: Bacterial CASP1 1 0.097 0.31
87 hsa04727 GABAergic synapse Organismal Systems Nervous system CACNA1A 1 0.1 0.31
88 hsa04725 Cholinergic synapse Organismal Systems Nervous system CACNA1A 1 0.1 0.32
89 hsa04724 Glutamatergic synapse Organismal Systems Nervous system CACNA1A 1 0.095 0.32
90 hsa04071 Sphingolipid signaling pathway Environmental Information Processing Signal transduction TNF 1 0.098 0.33
91 hsa04722 Neurotrophin signaling pathway Organismal Systems Nervous system ABL1 1 0.094 0.33
92 hsa04270 Vascular smooth muscle contraction Organismal Systems Circulatory system PLA2G1B 1 0.1 0.33
93 hsa04110 Cell cycle Cellular Processes Cell growth and death ABL1 1 0.098 0.33
94 hsa04650 Natural killer cell mediated cytotoxicity Organismal Systems Immune system TNF 1 0.1 0.34
95 hsa04728 Dopaminergic synapse Organismal Systems Nervous system CACNA1A 1 0.12 0.34
96 hsa05160 Hepatitis C Human Diseases Infectious diseases: Viral TNF 1 0.1 0.34
97 hsa04910 Insulin signaling pathway Organismal Systems Endocrine system PYGL 1 0.1 0.35
98 hsa05161 Hepatitis B Human Diseases Infectious diseases: Viral TNF 1 0.1 0.36
99 hsa04921 Oxytocin signaling pathway Organismal Systems Endocrine system PTGS2 1 0.099 0.36
100 hsa04145 Phagosome Cellular Processes Transport and catabolism FCGR1A 1 0.11 0.36
101 hsa04150 mTOR signaling pathway Environmental Information Processing Signal transduction TNF 1 0.1 0.36
102 hsa04932 Non-alcoholic fatty liver disease (NAFLD) Human Diseases Endocrine and metabolic diseases TNF 1 0.095 0.36
103 hsa05225 Hepatocellular carcinoma Human Diseases Cancers: Specific types GSTA1 1 0.094 0.39
104 hsa05010 Alzheimer disease Human Diseases Neurodegenerative diseases TNF 1 0.098 0.39
105 hsa04360 Axon guidance Organismal Systems Development ABL1 1 0.11 0.39
106 hsa05167 Kaposi sarcoma-associated herpesvirus infection Human Diseases Infectious diseases: Viral PTGS2 1 0.1 0.39
107 hsa05202 Transcriptional misregulation in cancer Human Diseases Cancers: Overview FCGR1A 1 0.1 0.39
108 hsa05168 Herpes simplex infection Human Diseases Infectious diseases: Viral TNF 1 0.1 0.4
109 hsa04020 Calcium signaling pathway Environmental Information Processing Signal transduction CACNA1A 1 0.18 0.4
110 hsa05205 Proteoglycans in cancer Human Diseases Cancers: Overview TNF 1 0.12 0.42
111 hsa05170 Human immunodeficiency virus 1 infection 0 0 TNF 1 0.098 0.43
112 hsa05166 Human T-cell leukemia virus 1 infection Human Diseases Infectious diseases: Viral TNF 1 0.097 0.49
113 hsa04060 Cytokine-cytokine receptor interaction Environmental Information Processing Signaling molecules and interaction TNF 1 0.1 0.53


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.