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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
The red circled blue spheres are used for the predicted targets.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB01812


6 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin Metabolism Glycan biosynthesis and metabolism NDST1;HS3ST1;HS3ST3A1 3 0.012 6.1E-6
2 hsa00140 Steroid hormone biosynthesis Metabolism Lipid metabolism SULT1E1;SULT2B1 2 0.052 0.0038
3 hsa05204 Chemical carcinogenesis Human Diseases Cancers: Overview SULT1A1;SULT2A1 2 0.061 0.0048
4 hsa04976 Bile secretion Organismal Systems Digestive system SULT2A1 1 0.063 0.083
5 hsa00980 Metabolism of xenobiotics by cytochrome P450 Metabolism Xenobiotics biodegradation and metabolism SULT2A1 1 0.052 0.083
6 hsa01100 Metabolic pathways Metabolism Global and overview maps NDST1 1 0.27 0.74


67 pathways for predicted targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa00590 Arachidonic acid metabolism Metabolism Lipid metabolism PLA2G2A;ALOX5;PTGS2 3 0.14 0.02
2 hsa04931 Insulin resistance Human Diseases Endocrine and metabolic diseases PPARA;PTPN1;PYGL 3 0.12 0.047
3 hsa04913 Ovarian steroidogenesis Organismal Systems Endocrine system ALOX5;PTGS2 2 0.15 0.1
4 hsa05150 Staphylococcus aureus infection Human Diseases Infectious diseases: Bacterial C1QB;FCGR2C 2 0.13 0.1
5 hsa05140 Leishmaniasis Human Diseases Infectious diseases: Parasitic PTGS2;FCGR2C 2 0.15 0.12
6 hsa04917 Prolactin signaling pathway Organismal Systems Endocrine system ESR1;ESR2 2 0.12 0.12
7 hsa04922 Glucagon signaling pathway Organismal Systems Endocrine system PPARA;PYGL 2 0.15 0.15
8 hsa01522 Endocrine resistance Human Diseases Drug resistance: Antineoplastic ESR1;ESR2 2 0.11 0.15
9 hsa00564 Glycerophospholipid metabolism Metabolism Lipid metabolism ACHE;PLA2G2A 2 0.14 0.15
10 hsa04726 Serotonergic synapse Organismal Systems Nervous system ALOX5;PTGS2 2 0.14 0.16
11 hsa05224 Breast cancer Human Diseases Cancers: Specific types ESR1;ESR2 2 0.11 0.18
12 hsa00100 Steroid biosynthesis Metabolism Lipid metabolism SQLE 1 0.13 0.18
13 hsa00910 Nitrogen metabolism Metabolism Energy metabolism CA1 1 0.13 0.18
14 hsa04915 Estrogen signaling pathway Organismal Systems Endocrine system ESR1;ESR2 2 0.13 0.18
15 hsa04910 Insulin signaling pathway Organismal Systems Endocrine system PTPN1;PYGL 2 0.13 0.19
16 hsa00592 alpha-Linolenic acid metabolism Metabolism Lipid metabolism PLA2G2A 1 0.17 0.22
17 hsa05310 Asthma Human Diseases Immune diseases RNASE3 1 0.14 0.23
18 hsa04024 cAMP signaling pathway Environmental Information Processing Signal transduction PPARA;GRIN3B 2 0.18 0.23
19 hsa00500 Starch and sucrose metabolism Metabolism Carbohydrate metabolism PYGL 1 0.15 0.24
20 hsa05020 Prion diseases Human Diseases Neurodegenerative diseases C1QB 1 0.13 0.24
21 hsa00591 Linoleic acid metabolism Metabolism Lipid metabolism PLA2G2A 1 0.13 0.24
22 hsa00510 N-Glycan biosynthesis Metabolism Glycan biosynthesis and metabolism MAN1B1 1 0.13 0.24
23 hsa05030 Cocaine addiction Human Diseases Substance dependence GRIN3B 1 0.12 0.24
24 hsa04975 Fat digestion and absorption Organismal Systems Digestive system PLA2G2A 1 0.13 0.25
25 hsa05033 Nicotine addiction Human Diseases Substance dependence GRIN3B 1 0.15 0.25
26 hsa05200 Pathways in cancer Human Diseases Cancers: Overview ESR1;PTGS2;ESR2 3 0.25 0.25
27 hsa00565 Ether lipid metabolism Metabolism Lipid metabolism PLA2G2A 1 0.16 0.25
28 hsa04923 Regulation of lipolysis in adipocytes Organismal Systems Endocrine system PTGS2 1 0.12 0.25
29 hsa04961 Endocrine and other factor-regulated calcium reabsorption Organismal Systems Excretory system ESR1 1 0.15 0.26
30 hsa04370 VEGF signaling pathway Environmental Information Processing Signal transduction PTGS2 1 0.13 0.27
31 hsa04920 Adipocytokine signaling pathway Organismal Systems Endocrine system PPARA 1 0.15 0.28
32 hsa05031 Amphetamine addiction Human Diseases Substance dependence GRIN3B 1 0.12 0.28
33 hsa05133 Pertussis Human Diseases Infectious diseases: Bacterial C1QB 1 0.13 0.28
34 hsa03320 PPAR signaling pathway Organismal Systems Endocrine system PPARA 1 0.14 0.28
35 hsa04520 Adherens junction Cellular Processes Cellular community - eukaryotes PTPN1 1 0.14 0.28
36 hsa04610 Complement and coagulation cascades Organismal Systems Immune system C1QB 1 0.14 0.28
37 hsa04664 Fc epsilon RI signaling pathway Organismal Systems Immune system ALOX5 1 0.14 0.29
38 hsa04972 Pancreatic secretion Organismal Systems Digestive system PLA2G2A 1 0.11 0.31
39 hsa04064 NF-kappa B signaling pathway Environmental Information Processing Signal transduction PTGS2 1 0.14 0.31
40 hsa04724 Glutamatergic synapse Organismal Systems Nervous system GRIN3B 1 0.14 0.31
41 hsa04919 Thyroid hormone signaling pathway Organismal Systems Endocrine system ESR1 1 0.11 0.31
42 hsa04657 IL-17 signaling pathway Organismal Systems Immune system PTGS2 1 0.11 0.31
43 hsa05145 Toxoplasmosis Human Diseases Infectious diseases: Parasitic ALOX5 1 0.13 0.31
44 hsa05222 Small cell lung cancer Human Diseases Cancers: Specific types PTGS2 1 0.12 0.31
45 hsa05142 Chagas disease (American trypanosomiasis) Human Diseases Infectious diseases: Parasitic C1QB 1 0.12 0.31
46 hsa04625 C-type lectin receptor signaling pathway Organismal Systems Immune system PTGS2 1 0.12 0.31
47 hsa04270 Vascular smooth muscle contraction Organismal Systems Circulatory system PLA2G2A 1 0.11 0.31
48 hsa04725 Cholinergic synapse Organismal Systems Nervous system ACHE 1 0.11 0.32
49 hsa04668 TNF signaling pathway Environmental Information Processing Signal transduction PTGS2 1 0.13 0.32
50 hsa05322 Systemic lupus erythematosus Human Diseases Immune diseases C1QB 1 0.13 0.32
51 hsa05160 Hepatitis C Human Diseases Infectious diseases: Viral PPARA 1 0.12 0.32
52 hsa04380 Osteoclast differentiation Organismal Systems Development FCGR2C 1 0.11 0.32
53 hsa04921 Oxytocin signaling pathway Organismal Systems Endocrine system PTGS2 1 0.11 0.34
54 hsa04145 Phagosome Cellular Processes Transport and catabolism FCGR2C 1 0.14 0.34
55 hsa04932 Non-alcoholic fatty liver disease (NAFLD) Human Diseases Endocrine and metabolic diseases PPARA 1 0.13 0.34
56 hsa04723 Retrograde endocannabinoid signaling Organismal Systems Nervous system PTGS2 1 0.11 0.34
57 hsa04217 Necroptosis Cellular Processes Cell growth and death PYGL 1 0.14 0.35
58 hsa04141 Protein processing in endoplasmic reticulum Genetic Information Processing Folding, sorting and degradation MAN1B1 1 0.13 0.35
59 hsa05152 Tuberculosis Human Diseases Infectious diseases: Bacterial FCGR2C 1 0.11 0.36
60 hsa05034 Alcoholism Human Diseases Substance dependence GRIN3B 1 0.11 0.36
61 hsa05167 Kaposi sarcoma-associated herpesvirus infection Human Diseases Infectious diseases: Viral PTGS2 1 0.11 0.36
62 hsa05205 Proteoglycans in cancer Human Diseases Cancers: Overview ESR1 1 0.13 0.38
63 hsa05163 Human cytomegalovirus infection 0 0 PTGS2 1 0.12 0.41
64 hsa04014 Ras signaling pathway Environmental Information Processing Signal transduction PLA2G2A 1 0.11 0.42
65 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction GRIN3B 1 0.27 0.47
66 hsa05206 MicroRNAs in cancer Human Diseases Cancers: Overview PTGS2 1 0.11 0.49
67 hsa05165 Human papillomavirus infection Human Diseases Infectious diseases: Viral PTGS2 1 0.13 0.52


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.