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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
The red circled blue spheres are used for the predicted targets.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB04429


0 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑


116 pathways for predicted targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa04919 Thyroid hormone signaling pathway Organismal Systems Endocrine system ESR1;SRC;PRKCA;NCOA2 4 0.12 0.0028
2 hsa01522 Endocrine resistance Human Diseases Drug resistance: Antineoplastic ESR1;SRC;BRAF;ESR2 4 0.11 0.0028
3 hsa04915 Estrogen signaling pathway Organismal Systems Endocrine system ESR1;SRC;ESR2;NCOA2 4 0.13 0.0036
4 hsa00140 Steroid hormone biosynthesis Metabolism Lipid metabolism SRD5A2;SRD5A1;CYP1B1 3 0.22 0.0046
5 hsa04917 Prolactin signaling pathway Organismal Systems Endocrine system ESR1;SRC;ESR2 3 0.12 0.0062
6 hsa04012 ErbB signaling pathway Environmental Information Processing Signal transduction SRC;BRAF;PRKCA 3 0.12 0.0067
7 hsa04727 GABAergic synapse Organismal Systems Nervous system SRC;CACNA1B;PRKCA 3 0.12 0.0067
8 hsa05205 Proteoglycans in cancer Human Diseases Cancers: Overview ESR1;SRC;BRAF;PRKCA 4 0.13 0.0068
9 hsa01521 EGFR tyrosine kinase inhibitor resistance Human Diseases Drug resistance: Antineoplastic SRC;BRAF;PRKCA 3 0.12 0.0068
10 hsa05215 Prostate cancer Human Diseases Cancers: Specific types BRAF;SRD5A2;AR 3 0.12 0.0081
11 hsa04726 Serotonergic synapse Organismal Systems Nervous system BRAF;CACNA1B;PRKCA 3 0.14 0.012
12 hsa05200 Pathways in cancer Human Diseases Cancers: Overview ESR1;BRAF;AR;PRKCA;ESR2 5 0.25 0.019
13 hsa05224 Breast cancer Human Diseases Cancers: Specific types ESR1;BRAF;ESR2 3 0.12 0.021
14 hsa05219 Bladder cancer Human Diseases Cancers: Specific types SRC;BRAF 2 0.15 0.021
15 hsa04961 Endocrine and other factor-regulated calcium reabsorption Organismal Systems Excretory system ESR1;PRKCA 2 0.13 0.026
16 hsa04510 Focal adhesion Cellular Processes Cellular community - eukaryotes SRC;BRAF;PRKCA 3 0.12 0.035
17 hsa04730 Long-term depression Organismal Systems Nervous system BRAF;PRKCA 2 0.16 0.035
18 hsa04015 Rap1 signaling pathway Environmental Information Processing Signal transduction SRC;BRAF;PRKCA 3 0.12 0.037
19 hsa04370 VEGF signaling pathway Environmental Information Processing Signal transduction SRC;PRKCA 2 0.12 0.037
20 hsa05223 Non-small cell lung cancer Human Diseases Cancers: Specific types BRAF;PRKCA 2 0.14 0.037
21 hsa04720 Long-term potentiation Organismal Systems Nervous system BRAF;PRKCA 2 0.12 0.037
22 hsa05214 Glioma Human Diseases Cancers: Specific types BRAF;PRKCA 2 0.16 0.04
23 hsa04540 Gap junction Cellular Processes Cellular community - eukaryotes SRC;PRKCA 2 0.11 0.057
24 hsa05032 Morphine addiction Human Diseases Substance dependence CACNA1B;PRKCA 2 0.11 0.059
25 hsa04912 GnRH signaling pathway Organismal Systems Endocrine system SRC;PRKCA 2 0.12 0.059
26 hsa04750 Inflammatory mediator regulation of TRP channels Organismal Systems Sensory system SRC;PRKCA 2 0.11 0.064
27 hsa04010 MAPK signaling pathway Environmental Information Processing Signal transduction BRAF;CACNA1B;PRKCA 3 0.12 0.067
28 hsa04928 Parathyroid hormone synthesis, secretion and action Organismal Systems Endocrine system BRAF;PRKCA 2 0.11 0.067
29 hsa04725 Cholinergic synapse Organismal Systems Nervous system CACNA1B;PRKCA 2 0.11 0.072
30 hsa04270 Vascular smooth muscle contraction Organismal Systems Circulatory system BRAF;PRKCA 2 0.12 0.081
31 hsa04650 Natural killer cell mediated cytotoxicity Organismal Systems Immune system BRAF;PRKCA 2 0.12 0.085
32 hsa04728 Dopaminergic synapse Organismal Systems Nervous system CACNA1B;PRKCA 2 0.12 0.085
33 hsa04926 Relaxin signaling pathway Organismal Systems Endocrine system SRC;PRKCA 2 0.12 0.088
34 hsa05161 Hepatitis B Human Diseases Infectious diseases: Viral SRC;PRKCA 2 0.11 0.098
35 hsa04921 Oxytocin signaling pathway Organismal Systems Endocrine system SRC;PRKCA 2 0.12 0.1
36 hsa04150 mTOR signaling pathway Environmental Information Processing Signal transduction BRAF;PRKCA 2 0.12 0.1
37 hsa04723 Retrograde endocannabinoid signaling Organismal Systems Nervous system CACNA1B;PRKCA 2 0.11 0.1
38 hsa00100 Steroid biosynthesis Metabolism Lipid metabolism SOAT2 1 0.43 0.11
39 hsa05225 Hepatocellular carcinoma Human Diseases Cancers: Specific types BRAF;PRKCA 2 0.11 0.11
40 hsa04360 Axon guidance Organismal Systems Development SRC;PRKCA 2 0.14 0.12
41 hsa04020 Calcium signaling pathway Environmental Information Processing Signal transduction CACNA1B;PRKCA 2 0.18 0.13
42 hsa04062 Chemokine signaling pathway Organismal Systems Immune system SRC;BRAF 2 0.11 0.13
43 hsa04810 Regulation of actin cytoskeleton Cellular Processes Cell motility SRC;BRAF 2 0.11 0.16
44 hsa05216 Thyroid cancer Human Diseases Cancers: Specific types BRAF 1 0.17 0.17
45 hsa04960 Aldosterone-regulated sodium reabsorption Organismal Systems Excretory system PRKCA 1 0.19 0.17
46 hsa05163 Human cytomegalovirus infection 0 0 SRC;PRKCA 2 0.12 0.17
47 hsa05143 African trypanosomiasis Human Diseases Infectious diseases: Parasitic PRKCA 1 0.23 0.17
48 hsa05033 Nicotine addiction Human Diseases Substance dependence CACNA1B 1 0.11 0.17
49 hsa00380 Tryptophan metabolism Metabolism Amino acid metabolism CYP1B1 1 0.22 0.17
50 hsa04975 Fat digestion and absorption Organismal Systems Digestive system MTTP 1 0.32 0.17
51 hsa04930 Type II diabetes mellitus Human Diseases Endocrine and metabolic diseases CACNA1B 1 0.12 0.19
52 hsa05110 Vibrio cholerae infection Human Diseases Infectious diseases: Bacterial PRKCA 1 0.28 0.19
53 hsa04979 Cholesterol metabolism Organismal Systems Digestive system SOAT2 1 0.27 0.19
54 hsa04913 Ovarian steroidogenesis Organismal Systems Endocrine system CYP1B1 1 0.12 0.2
55 hsa05130 Pathogenic Escherichia coli infection Human Diseases Infectious diseases: Bacterial PRKCA 1 0.25 0.21
56 hsa05220 Chronic myeloid leukemia Human Diseases Cancers: Specific types BRAF 1 0.17 0.21
57 hsa00980 Metabolism of xenobiotics by cytochrome P450 Metabolism Xenobiotics biodegradation and metabolism CYP1B1 1 0.18 0.21
58 hsa05213 Endometrial cancer Human Diseases Cancers: Specific types BRAF 1 0.18 0.21
59 hsa04971 Gastric acid secretion Organismal Systems Digestive system PRKCA 1 0.12 0.22
60 hsa05212 Pancreatic cancer Human Diseases Cancers: Specific types BRAF 1 0.12 0.22
61 hsa05206 MicroRNAs in cancer Human Diseases Cancers: Overview PRKCA;CYP1B1 2 0.11 0.22
62 hsa05031 Amphetamine addiction Human Diseases Substance dependence PRKCA 1 0.12 0.22
63 hsa05211 Renal cell carcinoma Human Diseases Cancers: Specific types BRAF 1 0.21 0.22
64 hsa04664 Fc epsilon RI signaling pathway Organismal Systems Immune system PRKCA 1 0.11 0.22
65 hsa04918 Thyroid hormone synthesis Organismal Systems Endocrine system PRKCA 1 0.18 0.22
66 hsa05100 Bacterial invasion of epithelial cells Human Diseases Infectious diseases: Bacterial SRC 1 0.25 0.22
67 hsa05218 Melanoma Human Diseases Cancers: Specific types BRAF 1 0.15 0.22
68 hsa04520 Adherens junction Cellular Processes Cellular community - eukaryotes SRC 1 0.11 0.22
69 hsa05120 Epithelial cell signaling in Helicobacter pylori infection Human Diseases Infectious diseases: Bacterial SRC 1 0.12 0.22
70 hsa05221 Acute myeloid leukemia Human Diseases Cancers: Specific types BRAF 1 0.14 0.22
71 hsa05131 Shigellosis Human Diseases Infectious diseases: Bacterial SRC 1 0.13 0.22
72 hsa04137 Mitophagy - animal Cellular Processes Transport and catabolism SRC 1 0.22 0.22
73 hsa04721 Synaptic vesicle cycle Organismal Systems Nervous system CACNA1B 1 0.27 0.22
74 hsa05204 Chemical carcinogenesis Human Diseases Cancers: Overview CYP1B1 1 0.13 0.22
75 hsa04911 Insulin secretion Organismal Systems Endocrine system PRKCA 1 0.11 0.23
76 hsa05210 Colorectal cancer Human Diseases Cancers: Specific types BRAF 1 0.13 0.23
77 hsa04916 Melanogenesis Organismal Systems Endocrine system PRKCA 1 0.17 0.23
78 hsa04066 HIF-1 signaling pathway Environmental Information Processing Signal transduction PRKCA 1 0.12 0.23
79 hsa04933 AGE-RAGE signaling pathway in diabetic complications Human Diseases Endocrine and metabolic diseases PRKCA 1 0.12 0.23
80 hsa05231 Choline metabolism in cancer Human Diseases Cancers: Overview PRKCA 1 0.15 0.23
81 hsa04625 C-type lectin receptor signaling pathway Organismal Systems Immune system SRC 1 0.12 0.23
82 hsa04070 Phosphatidylinositol signaling system Environmental Information Processing Signal transduction PRKCA 1 0.32 0.23
83 hsa05146 Amoebiasis Human Diseases Infectious diseases: Parasitic PRKCA 1 0.11 0.23
84 hsa04925 Aldosterone synthesis and secretion Organismal Systems Endocrine system PRKCA 1 0.14 0.23
85 hsa04666 Fc gamma R-mediated phagocytosis Organismal Systems Immune system PRKCA 1 0.2 0.23
86 hsa04970 Salivary secretion Organismal Systems Digestive system PRKCA 1 0.12 0.23
87 hsa04914 Progesterone-mediated oocyte maturation Organismal Systems Endocrine system BRAF 1 0.11 0.24
88 hsa04972 Pancreatic secretion Organismal Systems Digestive system PRKCA 1 0.11 0.24
89 hsa04713 Circadian entrainment Organismal Systems Environmental adaptation PRKCA 1 0.11 0.24
90 hsa04670 Leukocyte transendothelial migration Organismal Systems Immune system PRKCA 1 0.18 0.25
91 hsa04724 Glutamatergic synapse Organismal Systems Nervous system PRKCA 1 0.11 0.25
92 hsa04071 Sphingolipid signaling pathway Environmental Information Processing Signal transduction PRKCA 1 0.12 0.25
93 hsa04722 Neurotrophin signaling pathway Organismal Systems Nervous system BRAF 1 0.11 0.25
94 hsa04114 Oocyte meiosis Cellular Processes Cell growth and death AR 1 0.12 0.26
95 hsa04611 Platelet activation Organismal Systems Immune system SRC 1 0.11 0.26
96 hsa04068 FoxO signaling pathway Environmental Information Processing Signal transduction BRAF 1 0.12 0.26
97 hsa05160 Hepatitis C Human Diseases Infectious diseases: Viral BRAF 1 0.12 0.26
98 hsa04910 Insulin signaling pathway Organismal Systems Endocrine system BRAF 1 0.12 0.27
99 hsa05418 Fluid shear stress and atherosclerosis Human Diseases Cardiovascular diseases SRC 1 0.11 0.27
100 hsa04072 Phospholipase D signaling pathway Environmental Information Processing Signal transduction PRKCA 1 0.11 0.27
101 hsa04310 Wnt signaling pathway Environmental Information Processing Signal transduction PRKCA 1 0.16 0.27
102 hsa04261 Adrenergic signaling in cardiomyocytes Organismal Systems Circulatory system PRKCA 1 0.11 0.28
103 hsa05226 Gastric cancer Human Diseases Cancers: Specific types BRAF 1 0.12 0.28
104 hsa04934 Cushing syndrome Human Diseases Endocrine and metabolic diseases BRAF 1 0.12 0.28
105 hsa05164 Influenza A Human Diseases Infectious diseases: Viral PRKCA 1 0.11 0.3
106 hsa04530 Tight junction Cellular Processes Cellular community - eukaryotes SRC 1 0.12 0.3
107 hsa05034 Alcoholism Human Diseases Substance dependence BRAF 1 0.11 0.31
108 hsa05152 Tuberculosis Human Diseases Infectious diseases: Bacterial SRC 1 0.11 0.31
109 hsa05167 Kaposi sarcoma-associated herpesvirus infection Human Diseases Infectious diseases: Viral SRC 1 0.11 0.32
110 hsa04024 cAMP signaling pathway Environmental Information Processing Signal transduction BRAF 1 0.18 0.33
111 hsa05203 Viral carcinogenesis Human Diseases Cancers: Overview SRC 1 0.11 0.33
112 hsa05170 Human immunodeficiency virus 1 infection 0 0 PRKCA 1 0.12 0.34
113 hsa04014 Ras signaling pathway Environmental Information Processing Signal transduction PRKCA 1 0.11 0.37
114 hsa04144 Endocytosis Cellular Processes Transport and catabolism SRC 1 0.16 0.38
115 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction NR3C1 1 0.27 0.41
116 hsa04151 PI3K-Akt signaling pathway Environmental Information Processing Signal transduction PRKCA 1 0.17 0.49


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.