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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
The red circled blue spheres are used for the predicted targets.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB04371


6 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa04966 Collecting duct acid secretion Organismal Systems Excretory system CA2 1 0.069 0.0072
2 hsa04964 Proximal tubule bicarbonate reclamation Organismal Systems Excretory system CA2 1 0.05 0.0072
3 hsa00910 Nitrogen metabolism Metabolism Energy metabolism CA2 1 0.05 0.0092
4 hsa04971 Gastric acid secretion Organismal Systems Digestive system CA2 1 0.073 0.012
5 hsa04976 Bile secretion Organismal Systems Digestive system CA2 1 0.073 0.012
6 hsa04972 Pancreatic secretion Organismal Systems Digestive system CA2 1 0.089 0.013


48 pathways for predicted targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa04911 Insulin secretion Organismal Systems Endocrine system KCNJ11;ATP1A1;KCNMA1 3 0.13 0.028
2 hsa04022 cGMP-PKG signaling pathway Environmental Information Processing Signal transduction ADRA2C;ATP1A1;KCNMA1 3 0.13 0.092
3 hsa04970 Salivary secretion Organismal Systems Digestive system ATP1A1;KCNMA1 2 0.13 0.22
4 hsa04933 AGE-RAGE signaling pathway in diabetic complications Human Diseases Endocrine and metabolic diseases VEGFA 1 0.14 0.34
5 hsa04066 HIF-1 signaling pathway Environmental Information Processing Signal transduction VEGFA 1 0.14 0.34
6 hsa04974 Protein digestion and absorption Organismal Systems Digestive system ATP1A1 1 0.13 0.35
7 hsa05323 Rheumatoid arthritis Human Diseases Immune diseases VEGFA 1 0.14 0.35
8 hsa04925 Aldosterone synthesis and secretion Organismal Systems Endocrine system ATP1A1 1 0.15 0.35
9 hsa04742 Taste transduction Organismal Systems Sensory system HTR3A 1 0.14 0.35
10 hsa03018 RNA degradation Genetic Information Processing Folding, sorting and degradation DCPS 1 0.16 0.35
11 hsa04270 Vascular smooth muscle contraction Organismal Systems Circulatory system KCNMA1 1 0.13 0.35
12 hsa04611 Platelet activation Organismal Systems Immune system FGA 1 0.13 0.35
13 hsa04610 Complement and coagulation cascades Organismal Systems Immune system FGA 1 0.15 0.35
14 hsa04926 Relaxin signaling pathway Organismal Systems Endocrine system VEGFA 1 0.13 0.36
15 hsa04726 Serotonergic synapse Organismal Systems Nervous system HTR3A 1 0.15 0.36
16 hsa04919 Thyroid hormone signaling pathway Organismal Systems Endocrine system ATP1A1 1 0.13 0.36
17 hsa04261 Adrenergic signaling in cardiomyocytes Organismal Systems Circulatory system ATP1A1 1 0.13 0.36
18 hsa04072 Phospholipase D signaling pathway Environmental Information Processing Signal transduction ARF1 1 0.13 0.36
19 hsa05418 Fluid shear stress and atherosclerosis Human Diseases Cardiovascular diseases VEGFA 1 0.13 0.37
20 hsa01521 EGFR tyrosine kinase inhibitor resistance Human Diseases Drug resistance: Antineoplastic VEGFA 1 0.15 0.37
21 hsa04260 Cardiac muscle contraction Organismal Systems Circulatory system ATP1A1 1 0.21 0.39
22 hsa05212 Pancreatic cancer Human Diseases Cancers: Specific types VEGFA 1 0.13 0.41
23 hsa04918 Thyroid hormone synthesis Organismal Systems Endocrine system ATP1A1 1 0.14 0.42
24 hsa05205 Proteoglycans in cancer Human Diseases Cancers: Overview VEGFA 1 0.13 0.42
25 hsa04015 Rap1 signaling pathway Environmental Information Processing Signal transduction VEGFA 1 0.13 0.42
26 hsa04510 Focal adhesion Cellular Processes Cellular community - eukaryotes VEGFA 1 0.14 0.42
27 hsa05167 Kaposi sarcoma-associated herpesvirus infection Human Diseases Infectious diseases: Viral VEGFA 1 0.13 0.43
28 hsa04024 cAMP signaling pathway Environmental Information Processing Signal transduction ATP1A1 1 0.19 0.43
29 hsa04014 Ras signaling pathway Environmental Information Processing Signal transduction VEGFA 1 0.13 0.44
30 hsa05163 Human cytomegalovirus infection 0 0 VEGFA 1 0.13 0.44
31 hsa05211 Renal cell carcinoma Human Diseases Cancers: Specific types VEGFA 1 0.17 0.44
32 hsa04924 Renin secretion Organismal Systems Endocrine system KCNMA1 1 0.14 0.45
33 hsa04144 Endocytosis Cellular Processes Transport and catabolism ARF1 1 0.16 0.45
34 hsa05134 Legionellosis Human Diseases Infectious diseases: Bacterial ARF1 1 0.14 0.45
35 hsa04370 VEGF signaling pathway Environmental Information Processing Signal transduction VEGFA 1 0.14 0.45
36 hsa04978 Mineral absorption Organismal Systems Digestive system ATP1A1 1 0.27 0.46
37 hsa05110 Vibrio cholerae infection Human Diseases Infectious diseases: Bacterial ARF1 1 0.26 0.47
38 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction ADRA2C 1 0.27 0.48
39 hsa04010 MAPK signaling pathway Environmental Information Processing Signal transduction VEGFA 1 0.13 0.49
40 hsa05206 MicroRNAs in cancer Human Diseases Cancers: Overview VEGFA 1 0.13 0.49
41 hsa04961 Endocrine and other factor-regulated calcium reabsorption Organismal Systems Excretory system ATP1A1 1 0.13 0.51
42 hsa05165 Human papillomavirus infection Human Diseases Infectious diseases: Viral VEGFA 1 0.13 0.52
43 hsa04151 PI3K-Akt signaling pathway Environmental Information Processing Signal transduction VEGFA 1 0.18 0.53
44 hsa04930 Type II diabetes mellitus Human Diseases Endocrine and metabolic diseases KCNJ11 1 0.13 0.54
45 hsa04973 Carbohydrate digestion and absorption Organismal Systems Digestive system ATP1A1 1 0.2 0.61
46 hsa05200 Pathways in cancer Human Diseases Cancers: Overview VEGFA 1 0.26 0.67
47 hsa05219 Bladder cancer Human Diseases Cancers: Specific types VEGFA 1 0.15 0.68
48 hsa04960 Aldosterone-regulated sodium reabsorption Organismal Systems Excretory system ATP1A1 1 0.16 0.76


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.