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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
The red circled blue spheres are used for the predicted targets.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB00233


62 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa00590 Arachidonic acid metabolism Metabolism Lipid metabolism ALOX5;PTGS2;PLA2G2E 3 0.14 0.00014
2 hsa04913 Ovarian steroidogenesis Organismal Systems Endocrine system ALOX5;PTGS2 2 0.14 0.0078
3 hsa05145 Toxoplasmosis Human Diseases Infectious diseases: Parasitic ALOX5;CHUK 2 0.14 0.0095
4 hsa04726 Serotonergic synapse Organismal Systems Nervous system ALOX5;PTGS2 2 0.14 0.0095
5 hsa04668 TNF signaling pathway Environmental Information Processing Signal transduction PTGS2;CHUK 2 0.14 0.01
6 hsa04625 C-type lectin receptor signaling pathway Organismal Systems Immune system PTGS2;CHUK 2 0.11 0.011
7 hsa04064 NF-kappa B signaling pathway Environmental Information Processing Signal transduction PTGS2;CHUK 2 0.14 0.012
8 hsa04657 IL-17 signaling pathway Organismal Systems Immune system PTGS2;CHUK 2 0.11 0.012
9 hsa05222 Small cell lung cancer Human Diseases Cancers: Specific types PTGS2;CHUK 2 0.11 0.014
10 hsa05167 Kaposi sarcoma-associated herpesvirus infection Human Diseases Infectious diseases: Viral PTGS2;CHUK 2 0.11 0.022
11 hsa04014 Ras signaling pathway Environmental Information Processing Signal transduction PLA2G2E;CHUK 2 0.11 0.029
12 hsa05163 Human cytomegalovirus infection 0 0 PTGS2;CHUK 2 0.12 0.029
13 hsa05165 Human papillomavirus infection Human Diseases Infectious diseases: Viral PTGS2;CHUK 2 0.13 0.055
14 hsa00592 alpha-Linolenic acid metabolism Metabolism Lipid metabolism PLA2G2E 1 0.32 0.059
15 hsa00591 Linoleic acid metabolism Metabolism Lipid metabolism PLA2G2E 1 0.17 0.064
16 hsa01523 Antifolate resistance Human Diseases Drug resistance: Antineoplastic CHUK 1 0.22 0.064
17 hsa01100 Metabolic pathways Metabolism Global and overview maps ALOX5;PTGS2;PLA2G2E 3 0.27 0.066
18 hsa04975 Fat digestion and absorption Organismal Systems Digestive system PLA2G2E 1 0.17 0.075
19 hsa05220 Chronic myeloid leukemia Human Diseases Cancers: Specific types CHUK 1 0.21 0.075
20 hsa05212 Pancreatic cancer Human Diseases Cancers: Specific types CHUK 1 0.15 0.075
21 hsa05140 Leishmaniasis Human Diseases Infectious diseases: Parasitic PTGS2 1 0.14 0.077
22 hsa04662 B cell receptor signaling pathway Organismal Systems Immune system CHUK 1 0.21 0.077
23 hsa04622 RIG-I-like receptor signaling pathway Organismal Systems Immune system CHUK 1 0.24 0.077
24 hsa05204 Chemical carcinogenesis Human Diseases Cancers: Overview PTGS2 1 0.16 0.079
25 hsa04920 Adipocytokine signaling pathway Organismal Systems Endocrine system CHUK 1 0.2 0.079
26 hsa05120 Epithelial cell signaling in Helicobacter pylori infection Human Diseases Infectious diseases: Bacterial CHUK 1 0.14 0.081
27 hsa00565 Ether lipid metabolism Metabolism Lipid metabolism PLA2G2E 1 0.24 0.081
28 hsa05142 Chagas disease (American trypanosomiasis) Human Diseases Infectious diseases: Parasitic CHUK 1 0.12 0.082
29 hsa04620 Toll-like receptor signaling pathway Organismal Systems Immune system CHUK 1 0.14 0.082
30 hsa04664 Fc epsilon RI signaling pathway Organismal Systems Immune system ALOX5 1 0.15 0.082
31 hsa04659 Th17 cell differentiation Organismal Systems Immune system CHUK 1 0.13 0.083
32 hsa04660 T cell receptor signaling pathway Organismal Systems Immune system CHUK 1 0.14 0.083
33 hsa05215 Prostate cancer Human Diseases Cancers: Specific types CHUK 1 0.12 0.083
34 hsa00564 Glycerophospholipid metabolism Metabolism Lipid metabolism PLA2G2E 1 0.23 0.083
35 hsa05200 Pathways in cancer Human Diseases Cancers: Overview PTGS2;CHUK 2 0.25 0.084
36 hsa04923 Regulation of lipolysis in adipocytes Organismal Systems Endocrine system PTGS2 1 0.11 0.084
37 hsa04972 Pancreatic secretion Organismal Systems Digestive system PLA2G2E 1 0.11 0.085
38 hsa05221 Acute myeloid leukemia Human Diseases Cancers: Specific types CHUK 1 0.18 0.086
39 hsa04658 Th1 and Th2 cell differentiation Organismal Systems Immune system CHUK 1 0.19 0.086
40 hsa05131 Shigellosis Human Diseases Infectious diseases: Bacterial CHUK 1 0.17 0.087
41 hsa04370 VEGF signaling pathway Environmental Information Processing Signal transduction PTGS2 1 0.13 0.088
42 hsa04623 Cytosolic DNA-sensing pathway Organismal Systems Immune system CHUK 1 0.19 0.089
43 hsa05162 Measles Human Diseases Infectious diseases: Viral CHUK 1 0.12 0.091
44 hsa04068 FoxO signaling pathway Environmental Information Processing Signal transduction CHUK 1 0.11 0.091
45 hsa04270 Vascular smooth muscle contraction Organismal Systems Circulatory system PLA2G2E 1 0.11 0.091
46 hsa04210 Apoptosis Cellular Processes Cell growth and death CHUK 1 0.14 0.092
47 hsa05418 Fluid shear stress and atherosclerosis Human Diseases Cardiovascular diseases CHUK 1 0.11 0.092
48 hsa04150 mTOR signaling pathway Environmental Information Processing Signal transduction CHUK 1 0.15 0.092
49 hsa04921 Oxytocin signaling pathway Organismal Systems Endocrine system PTGS2 1 0.11 0.092
50 hsa05160 Hepatitis C Human Diseases Infectious diseases: Viral CHUK 1 0.13 0.093
51 hsa05161 Hepatitis B Human Diseases Infectious diseases: Viral CHUK 1 0.11 0.093
52 hsa04723 Retrograde endocannabinoid signaling Organismal Systems Nervous system PTGS2 1 0.11 0.094
53 hsa04380 Osteoclast differentiation Organismal Systems Development CHUK 1 0.11 0.094
54 hsa04621 NOD-like receptor signaling pathway Organismal Systems Immune system CHUK 1 0.13 0.1
55 hsa05168 Herpes simplex infection Human Diseases Infectious diseases: Viral CHUK 1 0.12 0.11
56 hsa04062 Chemokine signaling pathway Organismal Systems Immune system CHUK 1 0.15 0.11
57 hsa05169 Epstein-Barr virus infection Human Diseases Infectious diseases: Viral CHUK 1 0.11 0.11
58 hsa05170 Human immunodeficiency virus 1 infection 0 0 CHUK 1 0.12 0.12
59 hsa05166 Human T-cell leukemia virus 1 infection Human Diseases Infectious diseases: Viral CHUK 1 0.11 0.14
60 hsa04010 MAPK signaling pathway Environmental Information Processing Signal transduction CHUK 1 0.12 0.15
61 hsa05206 MicroRNAs in cancer Human Diseases Cancers: Overview PTGS2 1 0.11 0.15
62 hsa04151 PI3K-Akt signaling pathway Environmental Information Processing Signal transduction CHUK 1 0.17 0.18


35 pathways for predicted targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa04020 Calcium signaling pathway Environmental Information Processing Signal transduction ADRB1;DRD5;ADRB3;ADRA1D 4 0.19 0.0098
2 hsa04970 Salivary secretion Organismal Systems Digestive system ADRB1;ADRB3;ADRA1D 3 0.11 0.0098
3 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction ADRB1;DRD5;ADRB3;ADRA1D 4 0.27 0.016
4 hsa04022 cGMP-PKG signaling pathway Environmental Information Processing Signal transduction ADRB1;ADRB3;ADRA1D 3 0.13 0.027
5 hsa04024 cAMP signaling pathway Environmental Information Processing Signal transduction ADRB1;DRD5;CFTR 3 0.19 0.037
6 hsa04924 Renin secretion Organismal Systems Endocrine system ADRB1;ADRB3 2 0.1 0.037
7 hsa04931 Insulin resistance Human Diseases Endocrine and metabolic diseases PYGM;IKBKB 2 0.11 0.083
8 hsa04910 Insulin signaling pathway Organismal Systems Endocrine system PYGM;IKBKB 2 0.1 0.11
9 hsa04261 Adrenergic signaling in cardiomyocytes Organismal Systems Circulatory system ADRB1;ADRA1D 2 0.12 0.11
10 hsa04217 Necroptosis Cellular Processes Cell growth and death TYK2;PYGM 2 0.11 0.11
11 hsa04630 JAK-STAT signaling pathway Environmental Information Processing Signal transduction PIM1;TYK2 2 0.13 0.11
12 hsa05164 Influenza A Human Diseases Infectious diseases: Viral TYK2;IKBKB 2 0.11 0.12
13 hsa00500 Starch and sucrose metabolism Metabolism Carbohydrate metabolism PYGM 1 0.15 0.18
14 hsa04216 Ferroptosis Cellular Processes Cell growth and death SLC7A11 1 0.19 0.18
15 hsa04930 Type II diabetes mellitus Human Diseases Endocrine and metabolic diseases IKBKB 1 0.14 0.18
16 hsa02010 ABC transporters Environmental Information Processing Membrane transport CFTR 1 0.19 0.18
17 hsa05110 Vibrio cholerae infection Human Diseases Infectious diseases: Bacterial CFTR 1 0.18 0.18
18 hsa00140 Steroid hormone biosynthesis Metabolism Lipid metabolism AKR1C1 1 0.15 0.2
19 hsa00980 Metabolism of xenobiotics by cytochrome P450 Metabolism Xenobiotics biodegradation and metabolism AKR1C1 1 0.15 0.22
20 hsa00983 Drug metabolism - other enzymes Metabolism Xenobiotics biodegradation and metabolism MPO 1 0.14 0.22
21 hsa04971 Gastric acid secretion Organismal Systems Digestive system CFTR 1 0.12 0.22
22 hsa04540 Gap junction Cellular Processes Cellular community - eukaryotes ADRB1 1 0.12 0.23
23 hsa05414 Dilated cardiomyopathy (DCM) Human Diseases Cardiovascular diseases ADRB1 1 0.13 0.23
24 hsa04976 Bile secretion Organismal Systems Digestive system CFTR 1 0.12 0.23
25 hsa04933 AGE-RAGE signaling pathway in diabetic complications Human Diseases Endocrine and metabolic diseases PIM1 1 0.11 0.24
26 hsa04922 Glucagon signaling pathway Organismal Systems Endocrine system PYGM 1 0.14 0.24
27 hsa04611 Platelet activation Organismal Systems Immune system PTGS1 1 0.11 0.25
28 hsa04152 AMPK signaling pathway Environmental Information Processing Signal transduction CFTR 1 0.11 0.25
29 hsa04722 Neurotrophin signaling pathway Organismal Systems Nervous system IKBKB 1 0.12 0.25
30 hsa04728 Dopaminergic synapse Organismal Systems Nervous system DRD5 1 0.12 0.26
31 hsa04932 Non-alcoholic fatty liver disease (NAFLD) Human Diseases Endocrine and metabolic diseases IKBKB 1 0.12 0.27
32 hsa04145 Phagosome Cellular Processes Transport and catabolism MPO 1 0.14 0.27
33 hsa04530 Tight junction Cellular Processes Cellular community - eukaryotes CFTR 1 0.15 0.29
34 hsa05202 Transcriptional misregulation in cancer Human Diseases Cancers: Overview MPO 1 0.11 0.31
35 hsa04714 Thermogenesis Organismal Systems Environmental adaptation ADRB3 1 0.12 0.35


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.