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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
The red circled blue spheres are used for the predicted targets.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB00138


3 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa04974 Protein digestion and absorption Organismal Systems Digestive system SLC3A1;SLC7A9 2 0.05 0.0025
2 hsa04216 Ferroptosis Cellular Processes Cell growth and death SLC7A11 1 0.03 0.032
3 hsa04142 Lysosome Cellular Processes Transport and catabolism CTNS 1 0.03 0.064


89 pathways for predicted targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction ADRA2A;TSPO;PRSS1;ADRA1B;NR3C1;HRH4;CHRNA9;HRH1 8 0.27 9.1E-6
2 hsa04620 Toll-like receptor signaling pathway Organismal Systems Immune system IL1B;CTSK 2 0.14 0.19
3 hsa00130 Ubiquinone and other terpenoid-quinone biosynthesis Metabolism Metabolism of cofactors and vitamins NQO1 1 0.37 0.19
4 hsa05142 Chagas disease (American trypanosomiasis) Human Diseases Infectious diseases: Parasitic NOS2;IL1B 2 0.13 0.21
5 hsa04750 Inflammatory mediator regulation of TRP channels Organismal Systems Sensory system HRH1;IL1B 2 0.11 0.22
6 hsa05146 Amoebiasis Human Diseases Infectious diseases: Parasitic NOS2;IL1B 2 0.14 0.23
7 hsa05222 Small cell lung cancer Human Diseases Cancers: Specific types NOS2;CDK2 2 0.12 0.24
8 hsa00220 Arginine biosynthesis Metabolism Amino acid metabolism NOS2 1 0.17 0.24
9 hsa04932 Non-alcoholic fatty liver disease (NAFLD) Human Diseases Endocrine and metabolic diseases PPARA;IL1B 2 0.15 0.24
10 hsa04380 Osteoclast differentiation Organismal Systems Development IL1B;CTSK 2 0.11 0.25
11 hsa05162 Measles Human Diseases Infectious diseases: Viral CDK2;IL1B 2 0.12 0.25
12 hsa05418 Fluid shear stress and atherosclerosis Human Diseases Cardiovascular diseases NQO1;IL1B 2 0.11 0.26
13 hsa04261 Adrenergic signaling in cardiomyocytes Organismal Systems Circulatory system CACNG1;ADRA1B 2 0.12 0.26
14 hsa05323 Rheumatoid arthritis Human Diseases Immune diseases IL1B;CTSK 2 0.16 0.26
15 hsa04022 cGMP-PKG signaling pathway Environmental Information Processing Signal transduction ADRA2A;ADRA1B 2 0.13 0.27
16 hsa05164 Influenza A Human Diseases Infectious diseases: Viral PRSS1;IL1B 2 0.11 0.28
17 hsa05168 Herpes simplex infection Human Diseases Infectious diseases: Viral CDK2;IL1B 2 0.12 0.28
18 hsa01523 Antifolate resistance Human Diseases Drug resistance: Antineoplastic IL1B 1 0.17 0.28
19 hsa05132 Salmonella infection Human Diseases Infectious diseases: Bacterial NOS2;IL1B 2 0.15 0.29
20 hsa05152 Tuberculosis Human Diseases Infectious diseases: Bacterial NOS2;IL1B 2 0.11 0.29
21 hsa05020 Prion diseases Human Diseases Neurodegenerative diseases IL1B 1 0.17 0.29
22 hsa05143 African trypanosomiasis Human Diseases Infectious diseases: Parasitic IL1B 1 0.21 0.29
23 hsa05133 Pertussis Human Diseases Infectious diseases: Bacterial NOS2;IL1B 2 0.15 0.31
24 hsa05140 Leishmaniasis Human Diseases Infectious diseases: Parasitic NOS2;IL1B 2 0.14 0.31
25 hsa00330 Arginine and proline metabolism Metabolism Amino acid metabolism NOS2 1 0.16 0.32
26 hsa04979 Cholesterol metabolism Organismal Systems Digestive system TSPO 1 0.32 0.32
27 hsa02010 ABC transporters Environmental Information Processing Membrane transport ABCC8 1 0.26 0.32
28 hsa04940 Type I diabetes mellitus Human Diseases Endocrine and metabolic diseases IL1B 1 0.22 0.32
29 hsa05332 Graft-versus-host disease Human Diseases Immune diseases IL1B 1 0.24 0.32
30 hsa04930 Type II diabetes mellitus Human Diseases Endocrine and metabolic diseases ABCC8 1 0.16 0.32
31 hsa05144 Malaria Human Diseases Infectious diseases: Parasitic IL1B 1 0.16 0.33
32 hsa05134 Legionellosis Human Diseases Infectious diseases: Bacterial IL1B 1 0.16 0.34
33 hsa05200 Pathways in cancer Human Diseases Cancers: Overview NOS2;NQO1;CDK2 3 0.26 0.34
34 hsa04659 Th17 cell differentiation Organismal Systems Immune system IL1B 1 0.13 0.34
35 hsa04931 Insulin resistance Human Diseases Endocrine and metabolic diseases PPARA 1 0.12 0.34
36 hsa04668 TNF signaling pathway Environmental Information Processing Signal transduction IL1B 1 0.14 0.34
37 hsa04625 C-type lectin receptor signaling pathway Organismal Systems Immune system IL1B 1 0.12 0.34
38 hsa04922 Glucagon signaling pathway Organismal Systems Endocrine system PPARA 1 0.15 0.34
39 hsa04066 HIF-1 signaling pathway Environmental Information Processing Signal transduction NOS2 1 0.13 0.34
40 hsa04933 AGE-RAGE signaling pathway in diabetic complications Human Diseases Endocrine and metabolic diseases IL1B 1 0.12 0.34
41 hsa05145 Toxoplasmosis Human Diseases Infectious diseases: Parasitic NOS2 1 0.14 0.34
42 hsa04914 Progesterone-mediated oocyte maturation Organismal Systems Endocrine system CDK2 1 0.11 0.35
43 hsa04640 Hematopoietic cell lineage Organismal Systems Immune system IL1B 1 0.17 0.35
44 hsa05215 Prostate cancer Human Diseases Cancers: Specific types CDK2 1 0.12 0.35
45 hsa04068 FoxO signaling pathway Environmental Information Processing Signal transduction CDK2 1 0.11 0.35
46 hsa04728 Dopaminergic synapse Organismal Systems Nervous system SCN1A 1 0.12 0.35
47 hsa04371 Apelin signaling pathway Environmental Information Processing Signal transduction NOS2 1 0.14 0.36
48 hsa04210 Apoptosis Cellular Processes Cell growth and death CTSK 1 0.14 0.36
49 hsa04115 p53 signaling pathway Cellular Processes Cell growth and death CDK2 1 0.15 0.36
50 hsa05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) Human Diseases Cardiovascular diseases CACNG1 1 0.22 0.36
51 hsa03320 PPAR signaling pathway Organismal Systems Endocrine system PPARA 1 0.17 0.36
52 hsa04114 Oocyte meiosis Cellular Processes Cell growth and death CDK2 1 0.12 0.36
53 hsa04110 Cell cycle Cellular Processes Cell growth and death CDK2 1 0.14 0.36
54 hsa05160 Hepatitis C Human Diseases Infectious diseases: Viral PPARA 1 0.13 0.36
55 hsa04972 Pancreatic secretion Organismal Systems Digestive system PRSS1 1 0.11 0.36
56 hsa04623 Cytosolic DNA-sensing pathway Organismal Systems Immune system IL1B 1 0.26 0.36
57 hsa04270 Vascular smooth muscle contraction Organismal Systems Circulatory system ADRA1B 1 0.11 0.36
58 hsa05321 Inflammatory bowel disease (IBD) Human Diseases Immune diseases IL1B 1 0.18 0.36
59 hsa04911 Insulin secretion Organismal Systems Endocrine system ABCC8 1 0.15 0.36
60 hsa04146 Peroxisome Cellular Processes Transport and catabolism NOS2 1 0.19 0.36
61 hsa05410 Hypertrophic cardiomyopathy (HCM) Human Diseases Cardiovascular diseases CACNG1 1 0.17 0.36
62 hsa04610 Complement and coagulation cascades Organismal Systems Immune system F10 1 0.14 0.36
63 hsa04260 Cardiac muscle contraction Organismal Systems Circulatory system CACNG1 1 0.2 0.36
64 hsa04926 Relaxin signaling pathway Organismal Systems Endocrine system NOS2 1 0.11 0.36
65 hsa04064 NF-kappa B signaling pathway Environmental Information Processing Signal transduction IL1B 1 0.14 0.36
66 hsa04970 Salivary secretion Organismal Systems Digestive system ADRA1B 1 0.11 0.36
67 hsa05414 Dilated cardiomyopathy (DCM) Human Diseases Cardiovascular diseases CACNG1 1 0.14 0.36
68 hsa04010 MAPK signaling pathway Environmental Information Processing Signal transduction CACNG1;IL1B 2 0.12 0.37
69 hsa05161 Hepatitis B Human Diseases Infectious diseases: Viral CDK2 1 0.11 0.37
70 hsa04657 IL-17 signaling pathway Organismal Systems Immune system IL1B 1 0.11 0.37
71 hsa04920 Adipocytokine signaling pathway Organismal Systems Endocrine system PPARA 1 0.17 0.37
72 hsa05226 Gastric cancer Human Diseases Cancers: Specific types CDK2 1 0.12 0.37
73 hsa04921 Oxytocin signaling pathway Organismal Systems Endocrine system CACNG1 1 0.11 0.37
74 hsa04934 Cushing syndrome Human Diseases Endocrine and metabolic diseases CDK2 1 0.11 0.37
75 hsa04217 Necroptosis Cellular Processes Cell growth and death IL1B 1 0.14 0.38
76 hsa04218 Cellular senescence Cellular Processes Cell growth and death CDK2 1 0.11 0.38
77 hsa05225 Hepatocellular carcinoma Human Diseases Cancers: Specific types NQO1 1 0.15 0.38
78 hsa04621 NOD-like receptor signaling pathway Organismal Systems Immune system IL1B 1 0.13 0.38
79 hsa05010 Alzheimer disease Human Diseases Neurodegenerative diseases IL1B 1 0.12 0.38
80 hsa04020 Calcium signaling pathway Environmental Information Processing Signal transduction NOS2;ADRA1B;HRH1 3 0.19 0.4
81 hsa05203 Viral carcinogenesis Human Diseases Cancers: Overview CDK2 1 0.11 0.42
82 hsa05169 Epstein-Barr virus infection Human Diseases Infectious diseases: Viral CDK2 1 0.11 0.42
83 hsa04024 cAMP signaling pathway Environmental Information Processing Signal transduction PPARA 1 0.19 0.42
84 hsa05163 Human cytomegalovirus infection 0 0 IL1B 1 0.12 0.45
85 hsa05166 Human T-cell leukemia virus 1 infection Human Diseases Infectious diseases: Viral TSPO 1 0.12 0.49
86 hsa04060 Cytokine-cytokine receptor interaction Environmental Information Processing Signaling molecules and interaction IL1B 1 0.16 0.53
87 hsa05165 Human papillomavirus infection Human Diseases Infectious diseases: Viral CDK2 1 0.13 0.58
88 hsa04151 PI3K-Akt signaling pathway Environmental Information Processing Signal transduction CDK2 1 0.18 0.59
89 hsa01100 Metabolic pathways Metabolism Global and overview maps NOS2 1 0.27 0.97


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.