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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
The red circled blue spheres are used for the predicted targets.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB00145


43 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa00260 Glycine, serine and threonine metabolism Metabolism Amino acid metabolism GLDC;GCSH;GCAT;AGXT;ALAS1;AGXT2;SHMT2;ALAS2;PIPOX;SHMT1;GATM;GNMT 12 0.055 1.9E-20
2 hsa00630 Glyoxylate and dicarboxylate metabolism Metabolism Carbohydrate metabolism SHMT1;SHMT2;GLDC;GCSH;AGXT 5 0.047 8.0E-7
3 hsa05033 Nicotine addiction Human Diseases Substance dependence GRIN2A;SLC32A1;GRIN3B;GRIN2C 4 0.082 0.00012
4 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction GRIN2C;GLRA1;GRIN3B;GLRA3;GRIN2A;GLRB;GLRA2 7 0.27 0.00026
5 hsa01200 Carbon metabolism Metabolism Global and overview maps SHMT1;SHMT2;GLDC;GCSH;AGXT 5 0.063 0.0003
6 hsa01100 Metabolic pathways Metabolism Global and overview maps GLDC;GCSH;GSS;AGXT;ALAS1;AGXT2;SHMT2;ALAS2;PIPOX;SHMT1;GATM;BAAT 12 0.27 0.0028
7 hsa05030 Cocaine addiction Human Diseases Substance dependence GRIN2A;GRIN3B;GRIN2C 3 0.098 0.0034
8 hsa05031 Amphetamine addiction Human Diseases Substance dependence GRIN2A;GRIN3B;GRIN2C 3 0.098 0.0077
9 hsa00670 One carbon pool by folate Metabolism Metabolism of cofactors and vitamins SHMT1;SHMT2 2 0.051 0.0094
10 hsa04146 Peroxisome Cellular Processes Transport and catabolism BAAT;AGXT;PIPOX 3 0.055 0.011
11 hsa01523 Antifolate resistance Human Diseases Drug resistance: Antineoplastic SHMT1;SHMT2 2 0.063 0.018
12 hsa00250 Alanine, aspartate and glutamate metabolism Metabolism Amino acid metabolism AGXT2;AGXT 2 0.041 0.021
13 hsa04724 Glutamatergic synapse Organismal Systems Nervous system GRIN2A;GRIN3B;GRIN2C 3 0.082 0.021
14 hsa00860 Porphyrin and chlorophyll metabolism Metabolism Metabolism of cofactors and vitamins ALAS2;ALAS1 2 0.057 0.026
15 hsa00270 Cysteine and methionine metabolism Metabolism Amino acid metabolism AGXT2;GSS 2 0.046 0.028
16 hsa05014 Amyotrophic lateral sclerosis (ALS) Human Diseases Neurodegenerative diseases GRIN2A;GRIN2C 2 0.08 0.033
17 hsa04720 Long-term potentiation Organismal Systems Nervous system GRIN2A;GRIN2C 2 0.084 0.051
18 hsa05034 Alcoholism Human Diseases Substance dependence GRIN2A;GRIN3B;GRIN2C 3 0.11 0.051
19 hsa01230 Biosynthesis of amino acids Metabolism Global and overview maps SHMT1;SHMT2 2 0.052 0.058
20 hsa04024 cAMP signaling pathway Environmental Information Processing Signal transduction GRIN2A;GRIN3B;GRIN2C 3 0.19 0.059
21 hsa00430 Taurine and hypotaurine metabolism Metabolism Metabolism of other amino acids BAAT 1 0.027 0.074
22 hsa04713 Circadian entrainment Organismal Systems Environmental adaptation GRIN2A;GRIN2C 2 0.077 0.079
23 hsa00120 Primary bile acid biosynthesis Metabolism Lipid metabolism BAAT 1 0.023 0.099
24 hsa00360 Phenylalanine metabolism Metabolism Amino acid metabolism GLYAT 1 0.053 0.099
25 hsa01040 Biosynthesis of unsaturated fatty acids Metabolism Lipid metabolism BAAT 1 0.023 0.13
26 hsa05010 Alzheimer disease Human Diseases Neurodegenerative diseases GRIN2A;GRIN2C 2 0.097 0.18
27 hsa04216 Ferroptosis Cellular Processes Cell growth and death GSS 1 0.041 0.19
28 hsa04020 Calcium signaling pathway Environmental Information Processing Signal transduction GRIN2A;GRIN2C 2 0.19 0.19
29 hsa00280 Valine, leucine and isoleucine degradation Metabolism Amino acid metabolism AGXT2 1 0.043 0.22
30 hsa00330 Arginine and proline metabolism Metabolism Amino acid metabolism GATM 1 0.079 0.22
31 hsa00480 Glutathione metabolism Metabolism Metabolism of other amino acids GSS 1 0.055 0.24
32 hsa00310 Lysine degradation Metabolism Amino acid metabolism PIPOX 1 0.05 0.24
33 hsa04721 Synaptic vesicle cycle Organismal Systems Nervous system SLC32A1 1 0.052 0.25
34 hsa00970 Aminoacyl-tRNA biosynthesis Genetic Information Processing Translation GARS 1 0.05 0.25
35 hsa04976 Bile secretion Organismal Systems Digestive system BAAT 1 0.077 0.26
36 hsa04974 Protein digestion and absorption Organismal Systems Digestive system SLC36A1 1 0.08 0.3
37 hsa05032 Morphine addiction Human Diseases Substance dependence SLC32A1 1 0.1 0.3
38 hsa04727 GABAergic synapse Organismal Systems Nervous system SLC32A1 1 0.091 0.3
39 hsa05322 Systemic lupus erythematosus Human Diseases Immune diseases GRIN2A 1 0.052 0.39
40 hsa04728 Dopaminergic synapse Organismal Systems Nervous system GRIN2A 1 0.12 0.39
41 hsa04723 Retrograde endocannabinoid signaling Organismal Systems Nervous system SLC32A1 1 0.11 0.41
42 hsa04015 Rap1 signaling pathway Environmental Information Processing Signal transduction GRIN2A 1 0.12 0.52
43 hsa04014 Ras signaling pathway Environmental Information Processing Signal transduction GRIN2A 1 0.11 0.55


46 pathways for predicted targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa00290 Valine, leucine and isoleucine biosynthesis Metabolism Amino acid metabolism BCAT2;BCAT1 2 0.084 0.0017
2 hsa04730 Long-term depression Organismal Systems Nervous system NOS1;IGF1R;GRIA2 3 0.14 0.01
3 hsa00770 Pantothenate and CoA biosynthesis Metabolism Metabolism of cofactors and vitamins BCAT2;BCAT1 2 0.084 0.012
4 hsa00220 Arginine biosynthesis Metabolism Amino acid metabolism ARG1;NOS1 2 0.19 0.012
5 hsa01210 2-Oxocarboxylic acid metabolism Metabolism Global and overview maps BCAT2;BCAT1 2 0.075 0.012
6 hsa01522 Endocrine resistance Human Diseases Drug resistance: Antineoplastic ESR1;IGF1R 2 0.11 0.18
7 hsa00130 Ubiquinone and other terpenoid-quinone biosynthesis Metabolism Metabolism of cofactors and vitamins NQO1 1 0.075 0.18
8 hsa05224 Breast cancer Human Diseases Cancers: Specific types ESR1;IGF1R 2 0.11 0.3
9 hsa05225 Hepatocellular carcinoma Human Diseases Cancers: Specific types NQO1;IGF1R 2 0.11 0.34
10 hsa05418 Fluid shear stress and atherosclerosis Human Diseases Cardiovascular diseases NQO1 1 0.12 0.35
11 hsa04550 Signaling pathways regulating pluripotency of stem cells Cellular Processes Cellular community - eukaryotes IGF1R 1 0.13 0.35
12 hsa04150 mTOR signaling pathway Environmental Information Processing Signal transduction IGF1R 1 0.12 0.36
13 hsa04145 Phagosome Cellular Processes Transport and catabolism NOS1 1 0.17 0.36
14 hsa04915 Estrogen signaling pathway Organismal Systems Endocrine system ESR1 1 0.13 0.36
15 hsa04371 Apelin signaling pathway Environmental Information Processing Signal transduction NOS1 1 0.11 0.37
16 hsa04926 Relaxin signaling pathway Organismal Systems Endocrine system NOS1 1 0.11 0.38
17 hsa04068 FoxO signaling pathway Environmental Information Processing Signal transduction IGF1R 1 0.11 0.38
18 hsa05016 Huntington disease Human Diseases Neurodegenerative diseases GRIN2B;GRIN1 2 0.11 0.38
19 hsa05205 Proteoglycans in cancer Human Diseases Cancers: Overview ESR1;IGF1R 2 0.13 0.38
20 hsa04140 Autophagy - animal Cellular Processes Transport and catabolism IGF1R 1 0.11 0.38
21 hsa04914 Progesterone-mediated oocyte maturation Organismal Systems Endocrine system IGF1R 1 0.11 0.39
22 hsa04066 HIF-1 signaling pathway Environmental Information Processing Signal transduction IGF1R 1 0.12 0.39
23 hsa04520 Adherens junction Cellular Processes Cellular community - eukaryotes IGF1R 1 0.11 0.39
24 hsa05218 Melanoma Human Diseases Cancers: Specific types IGF1R 1 0.14 0.39
25 hsa04114 Oocyte meiosis Cellular Processes Cell growth and death IGF1R 1 0.12 0.39
26 hsa04152 AMPK signaling pathway Environmental Information Processing Signal transduction IGF1R 1 0.12 0.39
27 hsa04919 Thyroid hormone signaling pathway Organismal Systems Endocrine system ESR1 1 0.11 0.39
28 hsa04726 Serotonergic synapse Organismal Systems Nervous system GABRB3 1 0.14 0.39
29 hsa05215 Prostate cancer Human Diseases Cancers: Specific types IGF1R 1 0.13 0.4
30 hsa01521 EGFR tyrosine kinase inhibitor resistance Human Diseases Drug resistance: Antineoplastic IGF1R 1 0.12 0.4
31 hsa05146 Amoebiasis Human Diseases Infectious diseases: Parasitic ARG1 1 0.11 0.41
32 hsa04725 Cholinergic synapse Organismal Systems Nervous system CHRNA4 1 0.11 0.41
33 hsa05214 Glioma Human Diseases Cancers: Specific types IGF1R 1 0.16 0.41
34 hsa04211 Longevity regulating pathway Organismal Systems Aging IGF1R 1 0.13 0.41
35 hsa04970 Salivary secretion Organismal Systems Digestive system NOS1 1 0.11 0.41
36 hsa04913 Ovarian steroidogenesis Organismal Systems Endocrine system IGF1R 1 0.11 0.42
37 hsa04961 Endocrine and other factor-regulated calcium reabsorption Organismal Systems Excretory system ESR1 1 0.12 0.42
38 hsa05202 Transcriptional misregulation in cancer Human Diseases Cancers: Overview IGF1R 1 0.12 0.42
39 hsa04213 Longevity regulating pathway - multiple species Organismal Systems Aging IGF1R 1 0.19 0.42
40 hsa05200 Pathways in cancer Human Diseases Cancers: Overview ESR1;NQO1;IGF1R 3 0.25 0.42
41 hsa04917 Prolactin signaling pathway Organismal Systems Endocrine system ESR1 1 0.11 0.42
42 hsa04510 Focal adhesion Cellular Processes Cellular community - eukaryotes IGF1R 1 0.11 0.43
43 hsa00140 Steroid hormone biosynthesis Metabolism Lipid metabolism SULT2B1 1 0.19 0.45
44 hsa04144 Endocytosis Cellular Processes Transport and catabolism IGF1R 1 0.15 0.49
45 hsa04010 MAPK signaling pathway Environmental Information Processing Signal transduction IGF1R 1 0.13 0.55
46 hsa04151 PI3K-Akt signaling pathway Environmental Information Processing Signal transduction IGF1R 1 0.17 0.6


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.