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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
The red circled blue spheres are used for the predicted targets.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB00808


0 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑


65 pathways for predicted targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa00910 Nitrogen metabolism Metabolism Energy metabolism CA2;CA3;CA4;CA1 4 0.099 2.8E-6
2 hsa04964 Proximal tubule bicarbonate reclamation Organismal Systems Excretory system CA2;ATP1A1;CA4 3 0.097 0.00055
3 hsa04972 Pancreatic secretion Organismal Systems Digestive system CA2;ATP1A1;KCNMA1 3 0.11 0.027
4 hsa00030 Pentose phosphate pathway Metabolism Carbohydrate metabolism GPI;FBP1 2 0.27 0.033
5 hsa04022 cGMP-PKG signaling pathway Environmental Information Processing Signal transduction ATP1A1;ROCK2;KCNMA1 3 0.13 0.06
6 hsa04961 Endocrine and other factor-regulated calcium reabsorption Organismal Systems Excretory system ESR1;ATP1A1 2 0.095 0.06
7 hsa04976 Bile secretion Organismal Systems Digestive system CA2;ATP1A1 2 0.097 0.08
8 hsa04971 Gastric acid secretion Organismal Systems Digestive system CA2;ATP1A1 2 0.11 0.08
9 hsa00010 Glycolysis / Gluconeogenesis Metabolism Carbohydrate metabolism GPI;FBP1 2 0.11 0.08
10 hsa04924 Renin secretion Organismal Systems Endocrine system REN;KCNMA1 2 0.11 0.083
11 hsa04911 Insulin secretion Organismal Systems Endocrine system ATP1A1;KCNMA1 2 0.097 0.092
12 hsa04970 Salivary secretion Organismal Systems Digestive system ATP1A1;KCNMA1 2 0.11 0.094
13 hsa01200 Carbon metabolism Metabolism Global and overview maps GPI;FBP1 2 0.087 0.13
14 hsa04919 Thyroid hormone signaling pathway Organismal Systems Endocrine system ESR1;ATP1A1 2 0.11 0.13
15 hsa04270 Vascular smooth muscle contraction Organismal Systems Circulatory system ROCK2;KCNMA1 2 0.11 0.13
16 hsa04614 Renin-angiotensin system Organismal Systems Endocrine system REN 1 0.16 0.21
17 hsa04966 Collecting duct acid secretion Organismal Systems Excretory system CA2 1 0.13 0.23
18 hsa00500 Starch and sucrose metabolism Metabolism Carbohydrate metabolism GPI 1 0.15 0.23
19 hsa04960 Aldosterone-regulated sodium reabsorption Organismal Systems Excretory system ATP1A1 1 0.094 0.23
20 hsa05143 African trypanosomiasis Human Diseases Infectious diseases: Parasitic HBB 1 0.14 0.23
21 hsa05205 Proteoglycans in cancer Human Diseases Cancers: Overview ESR1;ROCK2 2 0.13 0.24
22 hsa04024 cAMP signaling pathway Environmental Information Processing Signal transduction ATP1A1;ROCK2 2 0.19 0.24
23 hsa00051 Fructose and mannose metabolism Metabolism Carbohydrate metabolism FBP1 1 0.18 0.25
24 hsa04973 Carbohydrate digestion and absorption Organismal Systems Digestive system ATP1A1 1 0.099 0.26
25 hsa05144 Malaria Human Diseases Infectious diseases: Parasitic HBB 1 0.089 0.26
26 hsa00520 Amino sugar and nucleotide sugar metabolism Metabolism Carbohydrate metabolism GPI 1 0.26 0.26
27 hsa04978 Mineral absorption Organismal Systems Digestive system ATP1A1 1 0.18 0.26
28 hsa05130 Pathogenic Escherichia coli infection Human Diseases Infectious diseases: Bacterial ROCK2 1 0.16 0.27
29 hsa04610 Complement and coagulation cascades Organismal Systems Immune system F10 1 0.11 0.29
30 hsa04260 Cardiac muscle contraction Organismal Systems Circulatory system ATP1A1 1 0.12 0.29
31 hsa00980 Metabolism of xenobiotics by cytochrome P450 Metabolism Xenobiotics biodegradation and metabolism CYP2B6 1 0.089 0.3
32 hsa04918 Thyroid hormone synthesis Organismal Systems Endocrine system ATP1A1 1 0.09 0.3
33 hsa00982 Drug metabolism - cytochrome P450 Metabolism Xenobiotics biodegradation and metabolism CYP2B6 1 0.087 0.3
34 hsa00830 Retinol metabolism Metabolism Metabolism of cofactors and vitamins CYP2B6 1 0.23 0.3
35 hsa05131 Shigellosis Human Diseases Infectious diseases: Bacterial ROCK2 1 0.095 0.3
36 hsa04917 Prolactin signaling pathway Organismal Systems Endocrine system ESR1 1 0.11 0.3
37 hsa00590 Arachidonic acid metabolism Metabolism Lipid metabolism CYP2B6 1 0.097 0.3
38 hsa05132 Salmonella infection Human Diseases Infectious diseases: Bacterial ROCK2 1 0.092 0.31
39 hsa04974 Protein digestion and absorption Organismal Systems Digestive system ATP1A1 1 0.1 0.31
40 hsa00564 Glycerophospholipid metabolism Metabolism Lipid metabolism ACHE 1 0.1 0.31
41 hsa01522 Endocrine resistance Human Diseases Drug resistance: Antineoplastic ESR1 1 0.11 0.31
42 hsa04925 Aldosterone synthesis and secretion Organismal Systems Endocrine system ATP1A1 1 0.096 0.32
43 hsa04922 Glucagon signaling pathway Organismal Systems Endocrine system FBP1 1 0.092 0.32
44 hsa04670 Leukocyte transendothelial migration Organismal Systems Immune system ROCK2 1 0.088 0.32
45 hsa04725 Cholinergic synapse Organismal Systems Nervous system ACHE 1 0.11 0.32
46 hsa04659 Th17 cell differentiation Organismal Systems Immune system AHR 1 0.11 0.32
47 hsa04071 Sphingolipid signaling pathway Environmental Information Processing Signal transduction ROCK2 1 0.11 0.33
48 hsa04152 AMPK signaling pathway Environmental Information Processing Signal transduction FBP1 1 0.11 0.33
49 hsa04611 Platelet activation Organismal Systems Immune system ROCK2 1 0.1 0.33
50 hsa04910 Insulin signaling pathway Organismal Systems Endocrine system FBP1 1 0.11 0.34
51 hsa04915 Estrogen signaling pathway Organismal Systems Endocrine system ESR1 1 0.13 0.34
52 hsa04310 Wnt signaling pathway Environmental Information Processing Signal transduction ROCK2 1 0.093 0.35
53 hsa05224 Breast cancer Human Diseases Cancers: Specific types ESR1 1 0.11 0.35
54 hsa04934 Cushing syndrome Human Diseases Endocrine and metabolic diseases AHR 1 0.11 0.35
55 hsa04921 Oxytocin signaling pathway Organismal Systems Endocrine system ROCK2 1 0.1 0.35
56 hsa04261 Adrenergic signaling in cardiomyocytes Organismal Systems Circulatory system ATP1A1 1 0.11 0.35
57 hsa04530 Tight junction Cellular Processes Cellular community - eukaryotes ROCK2 1 0.095 0.37
58 hsa04360 Axon guidance Organismal Systems Development ROCK2 1 0.096 0.37
59 hsa05200 Pathways in cancer Human Diseases Cancers: Overview ESR1;ROCK2 2 0.26 0.37
60 hsa04062 Chemokine signaling pathway Organismal Systems Immune system ROCK2 1 0.098 0.38
61 hsa04510 Focal adhesion Cellular Processes Cellular community - eukaryotes ROCK2 1 0.11 0.39
62 hsa04810 Regulation of actin cytoskeleton Cellular Processes Cell motility ROCK2 1 0.11 0.41
63 hsa05163 Human cytomegalovirus infection 0 0 ROCK2 1 0.12 0.42
64 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction CHRNA2 1 0.27 0.48
65 hsa01100 Metabolic pathways Metabolism Global and overview maps CYP2B6;GPI;FBP1 3 0.27 0.58


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.