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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
The red circled blue spheres are used for the predicted targets.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB01120


24 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa04933 AGE-RAGE signaling pathway in diabetic complications Human Diseases Endocrine and metabolic diseases VEGFA 1 0.15 0.058
2 hsa04066 HIF-1 signaling pathway Environmental Information Processing Signal transduction VEGFA 1 0.16 0.058
3 hsa05323 Rheumatoid arthritis Human Diseases Immune diseases VEGFA 1 0.2 0.063
4 hsa04911 Insulin secretion Organismal Systems Endocrine system ABCC8 1 0.17 0.064
5 hsa01521 EGFR tyrosine kinase inhibitor resistance Human Diseases Drug resistance: Antineoplastic VEGFA 1 0.18 0.068
6 hsa05418 Fluid shear stress and atherosclerosis Human Diseases Cardiovascular diseases VEGFA 1 0.14 0.068
7 hsa04926 Relaxin signaling pathway Organismal Systems Endocrine system VEGFA 1 0.14 0.068
8 hsa05212 Pancreatic cancer Human Diseases Cancers: Specific types VEGFA 1 0.17 0.072
9 hsa04015 Rap1 signaling pathway Environmental Information Processing Signal transduction VEGFA 1 0.13 0.077
10 hsa05205 Proteoglycans in cancer Human Diseases Cancers: Overview VEGFA 1 0.13 0.077
11 hsa04014 Ras signaling pathway Environmental Information Processing Signal transduction VEGFA 1 0.14 0.077
12 hsa05163 Human cytomegalovirus infection 0 0 VEGFA 1 0.13 0.077
13 hsa04510 Focal adhesion Cellular Processes Cellular community - eukaryotes VEGFA 1 0.15 0.08
14 hsa05211 Renal cell carcinoma Human Diseases Cancers: Specific types VEGFA 1 0.3 0.08
15 hsa05167 Kaposi sarcoma-associated herpesvirus infection Human Diseases Infectious diseases: Viral VEGFA 1 0.14 0.084
16 hsa04370 VEGF signaling pathway Environmental Information Processing Signal transduction VEGFA 1 0.17 0.088
17 hsa04010 MAPK signaling pathway Environmental Information Processing Signal transduction VEGFA 1 0.13 0.09
18 hsa05206 MicroRNAs in cancer Human Diseases Cancers: Overview VEGFA 1 0.15 0.09
19 hsa04930 Type II diabetes mellitus Human Diseases Endocrine and metabolic diseases ABCC8 1 0.17 0.094
20 hsa04151 PI3K-Akt signaling pathway Environmental Information Processing Signal transduction VEGFA 1 0.17 0.097
21 hsa05165 Human papillomavirus infection Human Diseases Infectious diseases: Viral VEGFA 1 0.13 0.097
22 hsa02010 ABC transporters Environmental Information Processing Membrane transport ABCC8 1 0.26 0.098
23 hsa05200 Pathways in cancer Human Diseases Cancers: Overview VEGFA 1 0.25 0.14
24 hsa05219 Bladder cancer Human Diseases Cancers: Specific types VEGFA 1 0.24 0.14


99 pathways for predicted targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa05140 Leishmaniasis Human Diseases Infectious diseases: Parasitic ITGA4;IFNG 2 0.094 0.15
2 hsa04971 Gastric acid secretion Organismal Systems Digestive system ATP1A1;KCNJ1 2 0.094 0.15
3 hsa04918 Thyroid hormone synthesis Organismal Systems Endocrine system GPX6;ATP1A1 2 0.093 0.16
4 hsa05146 Amoebiasis Human Diseases Infectious diseases: Parasitic CASP3;ARG1;IFNG 3 0.086 0.17
5 hsa04974 Protein digestion and absorption Organismal Systems Digestive system ATP1A1;KCNN4 2 0.086 0.17
6 hsa04657 IL-17 signaling pathway Organismal Systems Immune system CASP3;IFNG 2 0.096 0.17
7 hsa04970 Salivary secretion Organismal Systems Digestive system ATP1A1;KCNN4 2 0.096 0.18
8 hsa01524 Platinum drug resistance Human Diseases Drug resistance: Antineoplastic CASP3;GSTP1 2 0.096 0.18
9 hsa04960 Aldosterone-regulated sodium reabsorption Organismal Systems Excretory system ATP1A1;KCNJ1 2 0.095 0.19
10 hsa04961 Endocrine and other factor-regulated calcium reabsorption Organismal Systems Excretory system ATP1A1;KLK1 2 0.09 0.2
11 hsa04976 Bile secretion Organismal Systems Digestive system ATP1A1;ABCG2 2 0.085 0.2
12 hsa00480 Glutathione metabolism Metabolism Metabolism of other amino acids GPX6;GSTP1 2 0.12 0.22
13 hsa00590 Arachidonic acid metabolism Metabolism Lipid metabolism GPX6;PTGS1 2 0.085 0.22
14 hsa05145 Toxoplasmosis Human Diseases Infectious diseases: Parasitic CASP3;IFNG 2 0.095 0.22
15 hsa04726 Serotonergic synapse Organismal Systems Nervous system CASP3;PTGS1 2 0.14 0.22
16 hsa04650 Natural killer cell mediated cytotoxicity Organismal Systems Immune system CASP3;IFNG 2 0.09 0.27
17 hsa04964 Proximal tubule bicarbonate reclamation Organismal Systems Excretory system ATP1A1 1 0.097 0.3
18 hsa04614 Renin-angiotensin system Organismal Systems Endocrine system KLK1 1 0.13 0.3
19 hsa04022 cGMP-PKG signaling pathway Environmental Information Processing Signal transduction ATP1A1;KCNJ8 2 0.12 0.3
20 hsa04217 Necroptosis Cellular Processes Cell growth and death IFNG;PYGL 2 0.096 0.3
21 hsa00220 Arginine biosynthesis Metabolism Amino acid metabolism ARG1 1 0.098 0.3
22 hsa05330 Allograft rejection Human Diseases Immune diseases IFNG 1 0.16 0.32
23 hsa05340 Primary immunodeficiency Human Diseases Immune diseases ADA 1 0.23 0.32
24 hsa05014 Amyotrophic lateral sclerosis (ALS) Human Diseases Neurodegenerative diseases CASP3 1 0.088 0.32
25 hsa04978 Mineral absorption Organismal Systems Digestive system ATP1A1 1 0.2 0.32
26 hsa00500 Starch and sucrose metabolism Metabolism Carbohydrate metabolism PYGL 1 0.13 0.32
27 hsa05168 Herpes simplex infection Human Diseases Infectious diseases: Viral CASP3;IFNG 2 0.092 0.32
28 hsa04215 Apoptosis - multiple species Cellular Processes Cell growth and death CASP3 1 0.15 0.32
29 hsa05143 African trypanosomiasis Human Diseases Infectious diseases: Parasitic IFNG 1 0.12 0.32
30 hsa05134 Legionellosis Human Diseases Infectious diseases: Bacterial CASP3 1 0.089 0.32
31 hsa04923 Regulation of lipolysis in adipocytes Organismal Systems Endocrine system PTGS1 1 0.09 0.32
32 hsa04973 Carbohydrate digestion and absorption Organismal Systems Digestive system ATP1A1 1 0.11 0.33
33 hsa03050 Proteasome Genetic Information Processing Folding, sorting and degradation IFNG 1 0.29 0.33
34 hsa01523 Antifolate resistance Human Diseases Drug resistance: Antineoplastic ABCG2 1 0.088 0.33
35 hsa00330 Arginine and proline metabolism Metabolism Amino acid metabolism ARG1 1 0.096 0.33
36 hsa05152 Tuberculosis Human Diseases Infectious diseases: Bacterial CASP3;IFNG 2 0.096 0.33
37 hsa05332 Graft-versus-host disease Human Diseases Immune diseases IFNG 1 0.15 0.33
38 hsa04940 Type I diabetes mellitus Human Diseases Endocrine and metabolic diseases IFNG 1 0.14 0.33
39 hsa05144 Malaria Human Diseases Infectious diseases: Parasitic IFNG 1 0.091 0.33
40 hsa00140 Steroid hormone biosynthesis Metabolism Lipid metabolism STS 1 0.11 0.33
41 hsa05416 Viral myocarditis Human Diseases Cardiovascular diseases CASP3 1 0.18 0.33
42 hsa05215 Prostate cancer Human Diseases Cancers: Specific types GSTP1 1 0.12 0.33
43 hsa04640 Hematopoietic cell lineage Organismal Systems Immune system ITGA4 1 0.096 0.33
44 hsa05210 Colorectal cancer Human Diseases Cancers: Specific types CASP3 1 0.092 0.33
45 hsa05132 Salmonella infection Human Diseases Infectious diseases: Bacterial IFNG 1 0.09 0.33
46 hsa04672 Intestinal immune network for IgA production Organismal Systems Immune system ITGA4 1 0.27 0.33
47 hsa05142 Chagas disease (American trypanosomiasis) Human Diseases Infectious diseases: Parasitic IFNG 1 0.093 0.33
48 hsa04922 Glucagon signaling pathway Organismal Systems Endocrine system PYGL 1 0.088 0.33
49 hsa04659 Th17 cell differentiation Organismal Systems Immune system IFNG 1 0.093 0.33
50 hsa04931 Insulin resistance Human Diseases Endocrine and metabolic diseases PYGL 1 0.093 0.33
51 hsa04660 T cell receptor signaling pathway Organismal Systems Immune system IFNG 1 0.087 0.34
52 hsa04925 Aldosterone synthesis and secretion Organismal Systems Endocrine system ATP1A1 1 0.098 0.34
53 hsa04350 TGF-beta signaling pathway Environmental Information Processing Signal transduction IFNG 1 0.13 0.34
54 hsa05410 Hypertrophic cardiomyopathy (HCM) Human Diseases Cardiovascular diseases ITGA4 1 0.09 0.34
55 hsa04972 Pancreatic secretion Organismal Systems Digestive system ATP1A1 1 0.098 0.34
56 hsa04668 TNF signaling pathway Environmental Information Processing Signal transduction CASP3 1 0.094 0.34
57 hsa04512 ECM-receptor interaction Environmental Information Processing Signaling molecules and interaction ITGA4 1 0.36 0.34
58 hsa05222 Small cell lung cancer Human Diseases Cancers: Specific types CASP3 1 0.091 0.34
59 hsa04658 Th1 and Th2 cell differentiation Organismal Systems Immune system IFNG 1 0.096 0.34
60 hsa04670 Leukocyte transendothelial migration Organismal Systems Immune system ITGA4 1 0.089 0.34
61 hsa05414 Dilated cardiomyopathy (DCM) Human Diseases Cardiovascular diseases ITGA4 1 0.086 0.34
62 hsa05204 Chemical carcinogenesis Human Diseases Cancers: Overview GSTP1 1 0.094 0.34
63 hsa00983 Drug metabolism - other enzymes Metabolism Xenobiotics biodegradation and metabolism GSTP1 1 0.088 0.34
64 hsa04260 Cardiac muscle contraction Organismal Systems Circulatory system ATP1A1 1 0.11 0.34
65 hsa04919 Thyroid hormone signaling pathway Organismal Systems Endocrine system ATP1A1 1 0.099 0.34
66 hsa04612 Antigen processing and presentation Organismal Systems Immune system IFNG 1 0.091 0.34
67 hsa00980 Metabolism of xenobiotics by cytochrome P450 Metabolism Xenobiotics biodegradation and metabolism GSTP1 1 0.089 0.35
68 hsa05133 Pertussis Human Diseases Infectious diseases: Bacterial CASP3 1 0.085 0.35
69 hsa05321 Inflammatory bowel disease (IBD) Human Diseases Immune diseases IFNG 1 0.099 0.35
70 hsa00982 Drug metabolism - cytochrome P450 Metabolism Xenobiotics biodegradation and metabolism GSTP1 1 0.089 0.35
71 hsa05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) Human Diseases Cardiovascular diseases ITGA4 1 0.13 0.35
72 hsa01230 Biosynthesis of amino acids Metabolism Global and overview maps ARG1 1 0.099 0.36
73 hsa04611 Platelet activation Organismal Systems Immune system PTGS1 1 0.096 0.36
74 hsa05120 Epithelial cell signaling in Helicobacter pylori infection Human Diseases Infectious diseases: Bacterial CASP3 1 0.089 0.36
75 hsa04115 p53 signaling pathway Cellular Processes Cell growth and death CASP3 1 0.089 0.36
76 hsa04514 Cell adhesion molecules (CAMs) Environmental Information Processing Signaling molecules and interaction ITGA4 1 0.23 0.36
77 hsa04261 Adrenergic signaling in cardiomyocytes Organismal Systems Circulatory system ATP1A1 1 0.11 0.36
78 hsa04380 Osteoclast differentiation Organismal Systems Development IFNG 1 0.095 0.37
79 hsa04910 Insulin signaling pathway Organismal Systems Endocrine system PYGL 1 0.093 0.37
80 hsa04210 Apoptosis Cellular Processes Cell growth and death CASP3 1 0.094 0.37
81 hsa05162 Measles Human Diseases Infectious diseases: Viral IFNG 1 0.09 0.37
82 hsa05322 Systemic lupus erythematosus Human Diseases Immune diseases IFNG 1 0.1 0.37
83 hsa05161 Hepatitis B Human Diseases Infectious diseases: Viral CASP3 1 0.1 0.37
84 hsa04932 Non-alcoholic fatty liver disease (NAFLD) Human Diseases Endocrine and metabolic diseases CASP3 1 0.085 0.37
85 hsa05012 Parkinson disease Human Diseases Neurodegenerative diseases CASP3 1 0.094 0.37
86 hsa04630 JAK-STAT signaling pathway Environmental Information Processing Signal transduction IFNG 1 0.088 0.39
87 hsa05164 Influenza A Human Diseases Infectious diseases: Viral IFNG 1 0.098 0.4
88 hsa05010 Alzheimer disease Human Diseases Neurodegenerative diseases CASP3 1 0.091 0.4
89 hsa00230 Purine metabolism Metabolism Nucleotide metabolism ADA 1 0.086 0.4
90 hsa05225 Hepatocellular carcinoma Human Diseases Cancers: Specific types GSTP1 1 0.085 0.4
91 hsa05203 Viral carcinogenesis Human Diseases Cancers: Overview CASP3 1 0.098 0.43
92 hsa05169 Epstein-Barr virus infection Human Diseases Infectious diseases: Viral IFNG 1 0.098 0.43
93 hsa05016 Huntington disease Human Diseases Neurodegenerative diseases CASP3 1 0.088 0.43
94 hsa04024 cAMP signaling pathway Environmental Information Processing Signal transduction ATP1A1 1 0.18 0.43
95 hsa04810 Regulation of actin cytoskeleton Cellular Processes Cell motility ITGA4 1 0.11 0.43
96 hsa01100 Metabolic pathways Metabolism Global and overview maps PTGS1;ARG1;ADA;PYGL 4 0.27 0.43
97 hsa05170 Human immunodeficiency virus 1 infection 0 0 CASP3 1 0.091 0.44
98 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction NR3C1 1 0.27 0.52
99 hsa04060 Cytokine-cytokine receptor interaction Environmental Information Processing Signaling molecules and interaction IFNG 1 0.09 0.53


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.