QuartataWeb
Home  |   About  |   Theory  |   Tutorials  |   FAQ  |   Bahar Lab  |   Statistics   |  Return to main result page
 


Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB01120


24 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa04933 AGE-RAGE signaling pathway in diabetic complications Human Diseases Endocrine and metabolic diseases VEGFA 1 0.15 0.058
2 hsa04066 HIF-1 signaling pathway Environmental Information Processing Signal transduction VEGFA 1 0.16 0.058
3 hsa05323 Rheumatoid arthritis Human Diseases Immune diseases VEGFA 1 0.2 0.063
4 hsa04911 Insulin secretion Organismal Systems Endocrine system ABCC8 1 0.17 0.064
5 hsa01521 EGFR tyrosine kinase inhibitor resistance Human Diseases Drug resistance: Antineoplastic VEGFA 1 0.18 0.068
6 hsa05418 Fluid shear stress and atherosclerosis Human Diseases Cardiovascular diseases VEGFA 1 0.14 0.068
7 hsa04926 Relaxin signaling pathway Organismal Systems Endocrine system VEGFA 1 0.14 0.068
8 hsa05212 Pancreatic cancer Human Diseases Cancers: Specific types VEGFA 1 0.17 0.072
9 hsa04015 Rap1 signaling pathway Environmental Information Processing Signal transduction VEGFA 1 0.13 0.077
10 hsa05205 Proteoglycans in cancer Human Diseases Cancers: Overview VEGFA 1 0.13 0.077
11 hsa04014 Ras signaling pathway Environmental Information Processing Signal transduction VEGFA 1 0.14 0.077
12 hsa05163 Human cytomegalovirus infection 0 0 VEGFA 1 0.13 0.077
13 hsa04510 Focal adhesion Cellular Processes Cellular community - eukaryotes VEGFA 1 0.15 0.08
14 hsa05211 Renal cell carcinoma Human Diseases Cancers: Specific types VEGFA 1 0.3 0.08
15 hsa05167 Kaposi sarcoma-associated herpesvirus infection Human Diseases Infectious diseases: Viral VEGFA 1 0.14 0.084
16 hsa04370 VEGF signaling pathway Environmental Information Processing Signal transduction VEGFA 1 0.17 0.088
17 hsa04010 MAPK signaling pathway Environmental Information Processing Signal transduction VEGFA 1 0.13 0.09
18 hsa05206 MicroRNAs in cancer Human Diseases Cancers: Overview VEGFA 1 0.15 0.09
19 hsa04930 Type II diabetes mellitus Human Diseases Endocrine and metabolic diseases ABCC8 1 0.17 0.094
20 hsa04151 PI3K-Akt signaling pathway Environmental Information Processing Signal transduction VEGFA 1 0.17 0.097
21 hsa05165 Human papillomavirus infection Human Diseases Infectious diseases: Viral VEGFA 1 0.13 0.097
22 hsa02010 ABC transporters Environmental Information Processing Membrane transport ABCC8 1 0.26 0.098
23 hsa05200 Pathways in cancer Human Diseases Cancers: Overview VEGFA 1 0.25 0.14
24 hsa05219 Bladder cancer Human Diseases Cancers: Specific types VEGFA 1 0.24 0.14


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.