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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB00167

10 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)
1 hsa00280 Valine, leucine and isoleucine degradation Metabolism Amino acid metabolism BCAT2;BCAT1;ACADSB 3 0.016 1.2E-5
2 hsa00290 Valine, leucine and isoleucine biosynthesis Metabolism Amino acid metabolism BCAT2;BCAT1 2 0.018 1.2E-5
3 hsa01210 2-Oxocarboxylic acid metabolism Metabolism Global and overview maps BCAT2;BCAT1 2 0.013 0.00015
4 hsa00770 Pantothenate and CoA biosynthesis Metabolism Metabolism of cofactors and vitamins BCAT2;BCAT1 2 0.019 0.00015
5 hsa00270 Cysteine and methionine metabolism Metabolism Amino acid metabolism BCAT2;BCAT1 2 0.016 0.0007
6 hsa00970 Aminoacyl-tRNA biosynthesis Genetic Information Processing Translation IARS2;IARS 2 0.016 0.0013
7 hsa01230 Biosynthesis of amino acids Metabolism Global and overview maps BCAT2;BCAT1 2 0.026 0.0014
8 hsa01212 Fatty acid metabolism Metabolism Global and overview maps ACADSB 1 0.013 0.035
9 hsa00071 Fatty acid degradation Metabolism Lipid metabolism ACADSB 1 0.016 0.035
10 hsa01100 Metabolic pathways Metabolism Global and overview maps BCAT2;BCAT1;ACADSB 3 0.27 0.039


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.