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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
The red circled blue spheres are used for the predicted targets.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB11633


35 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa04723 Retrograde endocannabinoid signaling Organismal Systems Nervous system CACNA1C;KCNJ9;KCNJ6 3 0.12 0.00079
2 hsa04921 Oxytocin signaling pathway Organismal Systems Endocrine system CACNA1C;KCNJ9;KCNJ6 3 0.12 0.00079
3 hsa04725 Cholinergic synapse Organismal Systems Nervous system CACNA1C;KCNQ1;KCNJ6 3 0.12 0.0008
4 hsa04726 Serotonergic synapse Organismal Systems Nervous system CACNA1C;KCNJ9;KCNJ6 3 0.14 0.0008
5 hsa04261 Adrenergic signaling in cardiomyocytes Organismal Systems Circulatory system CACNA1C;KCNQ1;SCN5A 3 0.13 0.00085
6 hsa04728 Dopaminergic synapse Organismal Systems Nervous system CACNA1C;KCNJ9;KCNJ6 3 0.13 0.00089
7 hsa04713 Circadian entrainment Organismal Systems Environmental adaptation CACNA1C;KCNJ9;KCNJ6 3 0.14 0.0011
8 hsa04930 Type II diabetes mellitus Human Diseases Endocrine and metabolic diseases CACNA1C;KCNJ11 2 0.2 0.0024
9 hsa04727 GABAergic synapse Organismal Systems Nervous system CACNA1C;KCNJ6 2 0.14 0.0068
10 hsa05032 Morphine addiction Human Diseases Substance dependence KCNJ9;KCNJ6 2 0.12 0.0068
11 hsa04911 Insulin secretion Organismal Systems Endocrine system CACNA1C;KCNJ11 2 0.14 0.007
12 hsa04915 Estrogen signaling pathway Organismal Systems Endocrine system KCNJ9;KCNJ6 2 0.13 0.014
13 hsa04925 Aldosterone synthesis and secretion Organismal Systems Endocrine system CACNA1C 1 0.22 0.097
14 hsa04972 Pancreatic secretion Organismal Systems Digestive system KCNQ1 1 0.12 0.097
15 hsa04912 GnRH signaling pathway Organismal Systems Endocrine system CACNA1C 1 0.14 0.1
16 hsa05414 Dilated cardiomyopathy (DCM) Human Diseases Cardiovascular diseases CACNA1C 1 0.17 0.1
17 hsa04974 Protein digestion and absorption Organismal Systems Digestive system KCNQ1 1 0.15 0.1
18 hsa04742 Taste transduction Organismal Systems Sensory system CACNA1C 1 0.13 0.1
19 hsa05410 Hypertrophic cardiomyopathy (HCM) Human Diseases Cardiovascular diseases CACNA1C 1 0.22 0.1
20 hsa05110 Vibrio cholerae infection Human Diseases Infectious diseases: Bacterial KCNQ1 1 0.31 0.11
21 hsa04260 Cardiac muscle contraction Organismal Systems Circulatory system CACNA1C 1 0.25 0.11
22 hsa04971 Gastric acid secretion Organismal Systems Digestive system KCNQ1 1 0.15 0.11
23 hsa05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) Human Diseases Cardiovascular diseases CACNA1C 1 0.25 0.11
24 hsa05031 Amphetamine addiction Human Diseases Substance dependence CACNA1C 1 0.13 0.11
25 hsa04720 Long-term potentiation Organismal Systems Nervous system CACNA1C 1 0.18 0.11
26 hsa04724 Glutamatergic synapse Organismal Systems Nervous system CACNA1C 1 0.16 0.11
27 hsa04270 Vascular smooth muscle contraction Organismal Systems Circulatory system CACNA1C 1 0.12 0.11
28 hsa04924 Renin secretion Organismal Systems Endocrine system CACNA1C 1 0.14 0.12
29 hsa04927 Cortisol synthesis and secretion Organismal Systems Endocrine system CACNA1C 1 0.23 0.12
30 hsa04934 Cushing syndrome Human Diseases Endocrine and metabolic diseases CACNA1C 1 0.13 0.14
31 hsa04022 cGMP-PKG signaling pathway Environmental Information Processing Signal transduction CACNA1C 1 0.13 0.14
32 hsa05010 Alzheimer disease Human Diseases Neurodegenerative diseases CACNA1C 1 0.13 0.14
33 hsa04020 Calcium signaling pathway Environmental Information Processing Signal transduction CACNA1C 1 0.18 0.15
34 hsa04024 cAMP signaling pathway Environmental Information Processing Signal transduction CACNA1C 1 0.18 0.15
35 hsa04010 MAPK signaling pathway Environmental Information Processing Signal transduction CACNA1C 1 0.13 0.21


9 pathways for predicted targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)↑
1 hsa05033 Nicotine addiction Human Diseases Substance dependence CACNA1A;CACNA1B 2 0.085 0.041
2 hsa04721 Synaptic vesicle cycle Organismal Systems Nervous system CACNA1A;CACNA1B 2 0.085 0.049
3 hsa04730 Long-term depression Organismal Systems Nervous system CACNA1A 1 0.097 0.28
4 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction CHRM4;HRH1 2 0.27 0.28
5 hsa04973 Carbohydrate digestion and absorption Organismal Systems Digestive system CACNA1D 1 0.099 0.32
6 hsa04750 Inflammatory mediator regulation of TRP channels Organismal Systems Sensory system HRH1 1 0.11 0.34
7 hsa04530 Tight junction Cellular Processes Cellular community - eukaryotes CACNA1D 1 0.085 0.4
8 hsa04218 Cellular senescence Cellular Processes Cell growth and death CACNA1D 1 0.12 0.4
9 hsa04810 Regulation of actin cytoskeleton Cellular Processes Cell motility CHRM4 1 0.11 0.42


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.