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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
The red circled blue spheres are used for the predicted targets.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB01244


43 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)
1 hsa04020 Calcium signaling pathway Environmental Information Processing Signal transduction PDE1B;CACNA1H;CACNA1A;TNNC1;PDE1A 5 0.18 1.9E-5
2 hsa04261 Adrenergic signaling in cardiomyocytes Organismal Systems Circulatory system ATP1A1;KCNQ1;TNNC1;CACNA2D2 4 0.12 0.00019
3 hsa04260 Cardiac muscle contraction Organismal Systems Circulatory system ATP1A1;TNNC1;CACNA2D2 3 0.14 0.00077
4 hsa04742 Taste transduction Organismal Systems Sensory system PDE1B;CACNA1A;PDE1A 3 0.11 0.00077
5 hsa05032 Morphine addiction Human Diseases Substance dependence PDE1B;CACNA1A;PDE1A 3 0.11 0.00081
6 hsa04925 Aldosterone synthesis and secretion Organismal Systems Endocrine system ATP1A1;CACNA1H 2 0.12 0.014
7 hsa04972 Pancreatic secretion Organismal Systems Digestive system ATP1A1;KCNQ1 2 0.11 0.014
8 hsa04924 Renin secretion Organismal Systems Endocrine system PDE1B;PDE1A 2 0.11 0.014
9 hsa04974 Protein digestion and absorption Organismal Systems Digestive system ATP1A1;KCNQ1 2 0.1 0.015
10 hsa05414 Dilated cardiomyopathy (DCM) Human Diseases Cardiovascular diseases TNNC1;CACNA2D2 2 0.11 0.015
11 hsa04010 MAPK signaling pathway Environmental Information Processing Signal transduction CACNA1H;CACNA1A;CACNA2D2 3 0.12 0.016
12 hsa05410 Hypertrophic cardiomyopathy (HCM) Human Diseases Cardiovascular diseases TNNC1;CACNA2D2 2 0.12 0.016
13 hsa04971 Gastric acid secretion Organismal Systems Digestive system ATP1A1;KCNQ1 2 0.1 0.016
14 hsa04725 Cholinergic synapse Organismal Systems Nervous system KCNQ1;CACNA1A 2 0.11 0.018
15 hsa00230 Purine metabolism Metabolism Nucleotide metabolism PDE1B;PDE1A 2 0.099 0.039
16 hsa04964 Proximal tubule bicarbonate reclamation Organismal Systems Excretory system ATP1A1 1 0.12 0.066
17 hsa04960 Aldosterone-regulated sodium reabsorption Organismal Systems Excretory system ATP1A1 1 0.11 0.099
18 hsa04978 Mineral absorption Organismal Systems Digestive system ATP1A1 1 0.18 0.1
19 hsa05110 Vibrio cholerae infection Human Diseases Infectious diseases: Bacterial KCNQ1 1 0.15 0.1
20 hsa05033 Nicotine addiction Human Diseases Substance dependence CACNA1A 1 0.11 0.1
21 hsa04961 Endocrine and other factor-regulated calcium reabsorption Organismal Systems Excretory system ATP1A1 1 0.12 0.1
22 hsa04930 Type II diabetes mellitus Human Diseases Endocrine and metabolic diseases CACNA1A 1 0.12 0.1
23 hsa04973 Carbohydrate digestion and absorption Organismal Systems Digestive system ATP1A1 1 0.13 0.1
24 hsa04927 Cortisol synthesis and secretion Organismal Systems Endocrine system CACNA1H 1 0.12 0.11
25 hsa04721 Synaptic vesicle cycle Organismal Systems Nervous system CACNA1A 1 0.27 0.11
26 hsa04730 Long-term depression Organismal Systems Nervous system CACNA1A 1 0.12 0.11
27 hsa04740 Olfactory transduction Organismal Systems Sensory system PDE1B;PDE1A 2 0.2 0.11
28 hsa04918 Thyroid hormone synthesis Organismal Systems Endocrine system ATP1A1 1 0.11 0.11
29 hsa05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) Human Diseases Cardiovascular diseases CACNA2D2 1 0.15 0.11
30 hsa04976 Bile secretion Organismal Systems Digestive system ATP1A1 1 0.094 0.11
31 hsa04727 GABAergic synapse Organismal Systems Nervous system CACNA1A 1 0.11 0.12
32 hsa04970 Salivary secretion Organismal Systems Digestive system ATP1A1 1 0.11 0.12
33 hsa04911 Insulin secretion Organismal Systems Endocrine system ATP1A1 1 0.097 0.12
34 hsa04713 Circadian entrainment Organismal Systems Environmental adaptation CACNA1H 1 0.094 0.12
35 hsa04726 Serotonergic synapse Organismal Systems Nervous system CACNA1A 1 0.14 0.14
36 hsa04919 Thyroid hormone signaling pathway Organismal Systems Endocrine system ATP1A1 1 0.11 0.14
37 hsa04724 Glutamatergic synapse Organismal Systems Nervous system CACNA1A 1 0.11 0.14
38 hsa04728 Dopaminergic synapse Organismal Systems Nervous system CACNA1A 1 0.12 0.15
39 hsa04934 Cushing syndrome Human Diseases Endocrine and metabolic diseases CACNA1H 1 0.12 0.16
40 hsa04921 Oxytocin signaling pathway Organismal Systems Endocrine system CACNA2D2 1 0.11 0.16
41 hsa04723 Retrograde endocannabinoid signaling Organismal Systems Nervous system CACNA1A 1 0.11 0.16
42 hsa04022 cGMP-PKG signaling pathway Environmental Information Processing Signal transduction ATP1A1 1 0.13 0.17
43 hsa04024 cAMP signaling pathway Environmental Information Processing Signal transduction ATP1A1 1 0.18 0.19


11 pathways for predicted targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)
1 hsa04270 Vascular smooth muscle contraction Organismal Systems Circulatory system ADRA1A;ADRA1B;CACNA1S;CACNA1F;CACNA1C;ADRA1D;CACNA1D 7 0.093 1.8E-7
2 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction ADRA2A;ADRA1A;ADRA1B;ADRB3;ADRA1D;ADRA2C 6 0.27 0.00034
3 hsa04912 GnRH signaling pathway Organismal Systems Endocrine system CACNA1C;CACNA1S;CACNA1D;CACNA1F 4 0.15 0.00034
4 hsa05010 Alzheimer disease Human Diseases Neurodegenerative diseases CACNA1C;CACNA1S;CACNA1D;CACNA1F 4 0.11 0.0027
5 hsa05031 Amphetamine addiction Human Diseases Substance dependence CACNA1C;CACNA1D 2 0.099 0.031
6 hsa04923 Regulation of lipolysis in adipocytes Organismal Systems Endocrine system ADRB3 1 0.1 0.25
7 hsa04720 Long-term potentiation Organismal Systems Nervous system CACNA1C 1 0.22 0.26
8 hsa04152 AMPK signaling pathway Environmental Information Processing Signal transduction ADRA1A 1 0.13 0.38
9 hsa04218 Cellular senescence Cellular Processes Cell growth and death CACNA1D 1 0.093 0.41
10 hsa04530 Tight junction Cellular Processes Cellular community - eukaryotes CACNA1D 1 0.25 0.41
11 hsa04714 Thermogenesis Organismal Systems Environmental adaptation ADRB3 1 0.18 0.46



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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.