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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
The red circled blue spheres are used for the predicted targets.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB05964


9 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)
1 hsa04015 Rap1 signaling pathway Environmental Information Processing Signal transduction DRD2 1 0.16 0.061
2 hsa04024 cAMP signaling pathway Environmental Information Processing Signal transduction DRD2 1 0.2 0.061
3 hsa05034 Alcoholism Human Diseases Substance dependence DRD2 1 0.22 0.067
4 hsa04728 Dopaminergic synapse Organismal Systems Nervous system DRD2 1 0.16 0.068
5 hsa05012 Parkinson disease Human Diseases Neurodegenerative diseases DRD2 1 0.34 0.068
6 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction DRD2 1 0.27 0.073
7 hsa04726 Serotonergic synapse Organismal Systems Nervous system SLC6A4 1 0.17 0.078
8 hsa04540 Gap junction Cellular Processes Cellular community - eukaryotes DRD2 1 0.19 0.092
9 hsa05030 Cocaine addiction Human Diseases Substance dependence DRD2 1 0.26 0.11


14 pathways for predicted targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)
1 hsa04020 Calcium signaling pathway Environmental Information Processing Signal transduction CHRM2;HTR2C;ADRA1A;DRD5;ADRA1B;DRD1;ADRA1D;CHRM1;HTR2A;HRH1;HTR2B;HTR7 12 0.18 4.8E-14
2 hsa04022 cGMP-PKG signaling pathway Environmental Information Processing Signal transduction ADRA2A;ADRA1A;ADRA1B;ADRA2B;ADRA1D;ADRA2C 6 0.14 2.1E-5
3 hsa04750 Inflammatory mediator regulation of TRP channels Organismal Systems Sensory system HRH1;HTR2A;HTR2B;HTR2C 4 0.14 0.00056
4 hsa04970 Salivary secretion Organismal Systems Digestive system ADRA1A;ADRA1B;ADRA1D 3 0.23 0.0058
5 hsa04270 Vascular smooth muscle contraction Organismal Systems Circulatory system ADRA1A;ADRA1B;ADRA1D 3 0.19 0.011
6 hsa04261 Adrenergic signaling in cardiomyocytes Organismal Systems Circulatory system ADRA1A;ADRA1B;ADRA1D 3 0.13 0.015
7 hsa05031 Amphetamine addiction Human Diseases Substance dependence DRD1;SLC6A3 2 0.37 0.028
8 hsa04742 Taste transduction Organismal Systems Sensory system HTR3A;HTR1A 2 0.28 0.036
9 hsa04725 Cholinergic synapse Organismal Systems Nervous system CHRM2;CHRM1 2 0.16 0.055
10 hsa04810 Regulation of actin cytoskeleton Cellular Processes Cell motility CHRM2;CHRM1 2 0.13 0.15
11 hsa05032 Morphine addiction Human Diseases Substance dependence DRD1 1 0.18 0.28
12 hsa04151 PI3K-Akt signaling pathway Environmental Information Processing Signal transduction CHRM2;CHRM1 2 0.18 0.29
13 hsa04152 AMPK signaling pathway Environmental Information Processing Signal transduction ADRA1A 1 0.51 0.3
14 hsa04014 Ras signaling pathway Environmental Information Processing Signal transduction HTR7 1 0.14 0.47



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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.