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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
The red circled blue spheres are used for the predicted targets.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB11386


0 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)


42 pathways for predicted targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)
1 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction ADRA1D;ADRA2C;DRD5;ADRA1B;HTR1A;HRH3;CHRM1;HTR2C;ADRA1A;CHRM3;HRH1;DRD2;ADRA2B 13 0.27 1.7E-14
2 hsa04020 Calcium signaling pathway Environmental Information Processing Signal transduction ADRA1D;ADRA1A;DRD5;ADRA1B;CACNA1C;CHRM1;HTR2C;CHRM3;HRH1 9 0.19 1.1E-9
3 hsa04261 Adrenergic signaling in cardiomyocytes Organismal Systems Circulatory system ADRA1A;ADRA1B;CACNA1C;ADRA1D;CACNA2D1;CACNG1 6 0.13 6.7E-6
4 hsa04022 cGMP-PKG signaling pathway Environmental Information Processing Signal transduction ADRA2C;ADRA1B;CACNA1C;ADRA2B;ADRA1D;ADRA1A 6 0.13 1.0E-5
5 hsa04970 Salivary secretion Organismal Systems Digestive system CHRM3;ADRA1B;ADRA1D;ADRA1A 4 0.14 0.00035
6 hsa04024 cAMP signaling pathway Environmental Information Processing Signal transduction CACNA1C;DRD5;CHRM1;DRD2;HTR1A 5 0.19 0.00042
7 hsa04726 Serotonergic synapse Organismal Systems Nervous system CACNA1C;SLC6A4;HTR1A;HTR2C 4 0.15 0.00065
8 hsa04270 Vascular smooth muscle contraction Organismal Systems Circulatory system CACNA1C;ADRA1A;ADRA1B;ADRA1D 4 0.14 0.0007
9 hsa05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) Human Diseases Cardiovascular diseases CACNA1C;CACNG1;CACNA2D1 3 0.45 0.0025
10 hsa04742 Taste transduction Organismal Systems Sensory system CACNA1C;CHRM3;HTR1A 3 0.15 0.0028
11 hsa05410 Hypertrophic cardiomyopathy (HCM) Human Diseases Cardiovascular diseases CACNA1C;CACNG1;CACNA2D1 3 0.32 0.0028
12 hsa04260 Cardiac muscle contraction Organismal Systems Circulatory system CACNA1C;CACNG1;CACNA2D1 3 0.43 0.0028
13 hsa05414 Dilated cardiomyopathy (DCM) Human Diseases Cardiovascular diseases CACNA1C;CACNG1;CACNA2D1 3 0.22 0.0033
14 hsa04725 Cholinergic synapse Organismal Systems Nervous system CACNA1C;CHRM3;CHRM1 3 0.13 0.0057
15 hsa04728 Dopaminergic synapse Organismal Systems Nervous system CACNA1C;DRD5;DRD2 3 0.13 0.0084
16 hsa04921 Oxytocin signaling pathway Organismal Systems Endocrine system CACNA1C;CACNG1;CACNA2D1 3 0.14 0.012
17 hsa04911 Insulin secretion Organismal Systems Endocrine system CACNA1C;CHRM3 2 0.2 0.038
18 hsa04540 Gap junction Cellular Processes Cellular community - eukaryotes DRD2;HTR2C 2 0.13 0.039
19 hsa04750 Inflammatory mediator regulation of TRP channels Organismal Systems Sensory system HRH1;HTR2C 2 0.13 0.046
20 hsa04010 MAPK signaling pathway Environmental Information Processing Signal transduction CACNA1C;CACNG1;CACNA2D1 3 0.13 0.058
21 hsa04810 Regulation of actin cytoskeleton Cellular Processes Cell motility CHRM3;CHRM1 2 0.13 0.17
22 hsa04930 Type II diabetes mellitus Human Diseases Endocrine and metabolic diseases CACNA1C 1 0.28 0.19
23 hsa05030 Cocaine addiction Human Diseases Substance dependence DRD2 1 0.15 0.19
24 hsa04720 Long-term potentiation Organismal Systems Nervous system CACNA1C 1 0.25 0.22
25 hsa05031 Amphetamine addiction Human Diseases Substance dependence CACNA1C 1 0.16 0.22
26 hsa04924 Renin secretion Organismal Systems Endocrine system CACNA1C 1 0.16 0.23
27 hsa04927 Cortisol synthesis and secretion Organismal Systems Endocrine system CACNA1C 1 0.34 0.23
28 hsa04971 Gastric acid secretion Organismal Systems Digestive system CHRM3 1 0.21 0.24
29 hsa04925 Aldosterone synthesis and secretion Organismal Systems Endocrine system CACNA1C 1 0.3 0.25
30 hsa04972 Pancreatic secretion Organismal Systems Digestive system CHRM3 1 0.13 0.25
31 hsa04713 Circadian entrainment Organismal Systems Environmental adaptation CACNA1C 1 0.2 0.26
32 hsa04727 GABAergic synapse Organismal Systems Nervous system CACNA1C 1 0.2 0.26
33 hsa04912 GnRH signaling pathway Organismal Systems Endocrine system CACNA1C 1 0.19 0.27
34 hsa04724 Glutamatergic synapse Organismal Systems Nervous system CACNA1C 1 0.21 0.28
35 hsa04152 AMPK signaling pathway Environmental Information Processing Signal transduction ADRA1A 1 0.17 0.29
36 hsa05012 Parkinson disease Human Diseases Neurodegenerative diseases DRD2 1 0.17 0.33
37 hsa04723 Retrograde endocannabinoid signaling Organismal Systems Nervous system CACNA1C 1 0.13 0.33
38 hsa04934 Cushing syndrome Human Diseases Endocrine and metabolic diseases CACNA1C 1 0.15 0.33
39 hsa05010 Alzheimer disease Human Diseases Neurodegenerative diseases CACNA1C 1 0.16 0.35
40 hsa05034 Alcoholism Human Diseases Substance dependence DRD2 1 0.14 0.36
41 hsa04015 Rap1 signaling pathway Environmental Information Processing Signal transduction DRD2 1 0.13 0.39
42 hsa04151 PI3K-Akt signaling pathway Environmental Information Processing Signal transduction CHRM1 1 0.18 0.56



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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.