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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
The red circled blue spheres are used for the predicted targets.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB00392


11 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)
1 hsa04024 cAMP signaling pathway Environmental Information Processing Signal transduction CHRM2;GRIN3A;CHRM1 3 0.2 0.0002
2 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction CHRM2;GRIN3A;CHRM1 3 0.27 0.00028
3 hsa04725 Cholinergic synapse Organismal Systems Nervous system CHRM2;CHRM1 2 0.16 0.0024
4 hsa04020 Calcium signaling pathway Environmental Information Processing Signal transduction CHRM2;CHRM1 2 0.2 0.0048
5 hsa04810 Regulation of actin cytoskeleton Cellular Processes Cell motility CHRM2;CHRM1 2 0.16 0.0052
6 hsa04151 PI3K-Akt signaling pathway Environmental Information Processing Signal transduction CHRM2;CHRM1 2 0.22 0.012
7 hsa05033 Nicotine addiction Human Diseases Substance dependence GRIN3A 1 0.26 0.025
8 hsa05030 Cocaine addiction Human Diseases Substance dependence GRIN3A 1 0.19 0.027
9 hsa05031 Amphetamine addiction Human Diseases Substance dependence GRIN3A 1 0.21 0.033
10 hsa04724 Glutamatergic synapse Organismal Systems Nervous system GRIN3A 1 0.26 0.05
11 hsa05034 Alcoholism Human Diseases Substance dependence GRIN3A 1 0.16 0.071


19 pathways for predicted targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)
1 hsa05014 Amyotrophic lateral sclerosis (ALS) Human Diseases Neurodegenerative diseases GRIN2A;GRIN2B;GRIN2C;GRIN2D;GRIN1 5 0.19 1.8E-6
2 hsa04720 Long-term potentiation Organismal Systems Nervous system GRIN2A;GRIN2B;GRIN2C;GRIN2D;GRIN1 5 0.24 3.7E-6
3 hsa04540 Gap junction Cellular Processes Cellular community - eukaryotes DRD1;DRD2;HTR2A;HTR2B;HTR2C 5 0.11 9.7E-6
4 hsa04713 Circadian entrainment Organismal Systems Environmental adaptation GRIN2A;GRIN2B;GRIN2C;GRIN2D;GRIN1 5 0.16 1.1E-5
5 hsa04726 Serotonergic synapse Organismal Systems Nervous system HTR3A;SLC6A4;HTR2A;HTR2B;HTR2C 5 0.13 2.2E-5
6 hsa05010 Alzheimer disease Human Diseases Neurodegenerative diseases GRIN2A;GRIN2B;GRIN2C;GRIN2D;GRIN1 5 0.15 0.00013
7 hsa04750 Inflammatory mediator regulation of TRP channels Organismal Systems Sensory system HRH1;HTR2A;HTR2B;HTR2C 4 0.12 0.00021
8 hsa04728 Dopaminergic synapse Organismal Systems Nervous system GRIN2A;DRD1;DRD2;GRIN2B 4 0.12 0.00054
9 hsa04015 Rap1 signaling pathway Environmental Information Processing Signal transduction GRIN2A;DRD2;GRIN2B;GRIN1 4 0.12 0.0027
10 hsa04742 Taste transduction Organismal Systems Sensory system HTR3A;CHRM3 2 0.14 0.03
11 hsa04014 Ras signaling pathway Environmental Information Processing Signal transduction GRIN2A;GRIN2B;GRIN1 3 0.11 0.03
12 hsa05322 Systemic lupus erythematosus Human Diseases Immune diseases GRIN2A;GRIN2B 2 0.42 0.063
13 hsa05012 Parkinson disease Human Diseases Neurodegenerative diseases DRD1;DRD2 2 0.15 0.066
14 hsa05016 Huntington disease Human Diseases Neurodegenerative diseases GRIN2B;GRIN1 2 0.29 0.11
15 hsa04972 Pancreatic secretion Organismal Systems Digestive system CHRM3 1 0.12 0.21
16 hsa05032 Morphine addiction Human Diseases Substance dependence DRD1 1 0.13 0.21
17 hsa04970 Salivary secretion Organismal Systems Digestive system CHRM3 1 0.13 0.21
18 hsa04971 Gastric acid secretion Organismal Systems Digestive system CHRM3 1 0.16 0.21
19 hsa04911 Insulin secretion Organismal Systems Endocrine system CHRM3 1 0.16 0.22



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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.