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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB06204

7 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)
1 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction OPRD1;OPRM1;OPRK1 3 0.27 0.0033
2 hsa04726 Serotonergic synapse Organismal Systems Nervous system HTR3A;SLC6A4 2 0.16 0.008
3 hsa04071 Sphingolipid signaling pathway Environmental Information Processing Signal transduction OPRD1 1 0.28 0.1
4 hsa04915 Estrogen signaling pathway Organismal Systems Endocrine system OPRM1 1 0.16 0.1
5 hsa04742 Taste transduction Organismal Systems Sensory system HTR3A 1 0.19 0.1
6 hsa05032 Morphine addiction Human Diseases Substance dependence OPRM1 1 0.19 0.1
7 hsa04022 cGMP-PKG signaling pathway Environmental Information Processing Signal transduction OPRD1 1 0.17 0.1


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.