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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB01338


11 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)
1 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction CHRM3;CHRNA2;CHRM2 3 0.27 0.00056
2 hsa04725 Cholinergic synapse Organismal Systems Nervous system CHRM3;CHRM2 2 0.16 0.0036
3 hsa04020 Calcium signaling pathway Environmental Information Processing Signal transduction CHRM3;CHRM2 2 0.2 0.0065
4 hsa04810 Regulation of actin cytoskeleton Cellular Processes Cell motility CHRM3;CHRM2 2 0.16 0.0066
5 hsa04970 Salivary secretion Organismal Systems Digestive system CHRM3 1 0.2 0.047
6 hsa04972 Pancreatic secretion Organismal Systems Digestive system CHRM3 1 0.16 0.047
7 hsa04911 Insulin secretion Organismal Systems Endocrine system CHRM3 1 0.34 0.049
8 hsa04742 Taste transduction Organismal Systems Sensory system CHRM3 1 0.22 0.053
9 hsa04971 Gastric acid secretion Organismal Systems Digestive system CHRM3 1 0.29 0.06
10 hsa04024 cAMP signaling pathway Environmental Information Processing Signal transduction CHRM2 1 0.2 0.085
11 hsa04151 PI3K-Akt signaling pathway Environmental Information Processing Signal transduction CHRM2 1 0.22 0.14



  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.