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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB00245


12 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)
1 hsa04020 Calcium signaling pathway Environmental Information Processing Signal transduction HRH1;CHRM1 2 0.2 0.021
2 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction HRH1;CHRM1 2 0.27 0.024
3 hsa05030 Cocaine addiction Human Diseases Substance dependence SLC6A3 1 0.26 0.078
4 hsa05031 Amphetamine addiction Human Diseases Substance dependence SLC6A3 1 0.3 0.081
5 hsa04728 Dopaminergic synapse Organismal Systems Nervous system SLC6A3 1 0.16 0.084
6 hsa05012 Parkinson disease Human Diseases Neurodegenerative diseases SLC6A3 1 0.44 0.084
7 hsa04725 Cholinergic synapse Organismal Systems Nervous system CHRM1 1 0.18 0.089
8 hsa04750 Inflammatory mediator regulation of TRP channels Organismal Systems Sensory system HRH1 1 0.17 0.089
9 hsa04810 Regulation of actin cytoskeleton Cellular Processes Cell motility CHRM1 1 0.16 0.091
10 hsa04024 cAMP signaling pathway Environmental Information Processing Signal transduction CHRM1 1 0.2 0.091
11 hsa05034 Alcoholism Human Diseases Substance dependence SLC6A3 1 0.21 0.093
12 hsa04151 PI3K-Akt signaling pathway Environmental Information Processing Signal transduction CHRM1 1 0.21 0.14



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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.