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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB01392


19 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)
1 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction ADRA2A;DRD3;HTR2C;ADRA2C;DRD2;HTR1A;HTR1D;ADRA2B;HTR2A;HTR1B;HTR2B 11 0.27 7.2E-11
2 hsa04726 Serotonergic synapse Organismal Systems Nervous system HTR1D;HTR1B;HTR1A;HTR2A;HTR2B;HTR2C 6 0.16 1.8E-6
3 hsa04540 Gap junction Cellular Processes Cellular community - eukaryotes DRD2;HTR2A;HTR2B;HTR2C 4 0.15 0.00031
4 hsa04022 cGMP-PKG signaling pathway Environmental Information Processing Signal transduction ADRA2A;KCNJ8;ADRA2B;ADRA2C 4 0.15 0.0025
5 hsa04971 Gastric acid secretion Organismal Systems Digestive system KCNJ15;KCNJ10;KCNJ1 3 0.25 0.0027
6 hsa04742 Taste transduction Organismal Systems Sensory system HTR1B;HTR1A;HTR1D 3 0.19 0.003
7 hsa04024 cAMP signaling pathway Environmental Information Processing Signal transduction HTR1B;DRD2;HTR1A;HTR1D 4 0.19 0.003
8 hsa04750 Inflammatory mediator regulation of TRP channels Organismal Systems Sensory system HTR2A;HTR2B;HTR2C 3 0.15 0.0038
9 hsa04020 Calcium signaling pathway Environmental Information Processing Signal transduction HTR2A;HTR2B;HTR2C 3 0.19 0.019
10 hsa04725 Cholinergic synapse Organismal Systems Nervous system KCNJ14;KCNJ12 2 0.16 0.055
11 hsa04728 Dopaminergic synapse Organismal Systems Nervous system DRD2;DRD3 2 0.15 0.067
12 hsa04921 Oxytocin signaling pathway Organismal Systems Endocrine system KCNJ14;KCNJ12 2 0.19 0.081
13 hsa04960 Aldosterone-regulated sodium reabsorption Organismal Systems Excretory system KCNJ1 1 0.41 0.13
14 hsa05030 Cocaine addiction Human Diseases Substance dependence DRD2 1 0.21 0.14
15 hsa04930 Type II diabetes mellitus Human Diseases Endocrine and metabolic diseases KCNJ11 1 0.32 0.14
16 hsa04911 Insulin secretion Organismal Systems Endocrine system KCNJ11 1 0.29 0.22
17 hsa05012 Parkinson disease Human Diseases Neurodegenerative diseases DRD2 1 0.24 0.33
18 hsa05034 Alcoholism Human Diseases Substance dependence DRD2 1 0.17 0.38
19 hsa04015 Rap1 signaling pathway Environmental Information Processing Signal transduction DRD2 1 0.15 0.4



  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.