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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB09167


18 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)
1 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction ADRA2A;CHRM2;ADRA1B;ADRA1D;CHRM5;ADRA2C;CHRM4;HTR1A;CHRM1;HTR2A;ADRA1A;CHRM3;HRH1;ADRA2B 14 0.27 1.8E-18
2 hsa04020 Calcium signaling pathway Environmental Information Processing Signal transduction CHRM5;ADRA1D;CHRM2;ADRA1A;ADRA1B;CHRM1;HTR2A;CHRM3;HRH1 9 0.19 1.0E-10
3 hsa04022 cGMP-PKG signaling pathway Environmental Information Processing Signal transduction ADRA2A;ADRA1A;ADRA1B;ADRA2B;ADRA1D;ADRA2C 6 0.16 2.5E-6
4 hsa04725 Cholinergic synapse Organismal Systems Nervous system CHRM3;CHRM2;CHRM4;CHRM1;CHRM5 5 0.18 8.3E-6
5 hsa04970 Salivary secretion Organismal Systems Digestive system CHRM3;ADRA1B;ADRA1D;ADRA1A 4 0.24 8.7E-5
6 hsa04810 Regulation of actin cytoskeleton Cellular Processes Cell motility CHRM3;CHRM2;CHRM4;CHRM1;CHRM5 5 0.15 0.00013
7 hsa04726 Serotonergic synapse Organismal Systems Nervous system SLC6A4;HTR1A;HTR2A 3 0.17 0.0036
8 hsa04270 Vascular smooth muscle contraction Organismal Systems Circulatory system ADRA1A;ADRA1B;ADRA1D 3 0.23 0.0037
9 hsa04261 Adrenergic signaling in cardiomyocytes Organismal Systems Circulatory system ADRA1A;ADRA1B;ADRA1D 3 0.15 0.0054
10 hsa04024 cAMP signaling pathway Environmental Information Processing Signal transduction CHRM2;CHRM1;HTR1A 3 0.19 0.012
11 hsa04742 Taste transduction Organismal Systems Sensory system CHRM3;HTR1A 2 0.29 0.019
12 hsa04750 Inflammatory mediator regulation of TRP channels Organismal Systems Sensory system HRH1;HTR2A 2 0.17 0.024
13 hsa04911 Insulin secretion Organismal Systems Endocrine system CHRM3 1 0.55 0.18
14 hsa04540 Gap junction Cellular Processes Cellular community - eukaryotes HTR2A 1 0.16 0.18
15 hsa04972 Pancreatic secretion Organismal Systems Digestive system CHRM3 1 0.2 0.19
16 hsa04151 PI3K-Akt signaling pathway Environmental Information Processing Signal transduction CHRM2;CHRM1 2 0.2 0.19
17 hsa04971 Gastric acid secretion Organismal Systems Digestive system CHRM3 1 0.4 0.19
18 hsa04152 AMPK signaling pathway Environmental Information Processing Signal transduction ADRA1A 1 0.35 0.22



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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.