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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB09304


9 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)
1 hsa04726 Serotonergic synapse Organismal Systems Nervous system HTR3E;HTR3D;HTR4;HTR3B;HTR3A;HTR1B;HTR1A;HTR3C;HTR1D;HTR2C;HTR2A;HTR6;HTR1F;HTR7;HTR2B;HTR1E 16 0.2 2.8E-26
2 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction ADRA2A;HTR4;ADRA2C;HTR6;HTR1A;HTR1D;HTR2C;HTR2A;HTR1B;HTR1F;HTR7;ADRA2B;HTR2B;HTR1E 14 0.27 3.0E-16
3 hsa04742 Taste transduction Organismal Systems Sensory system HTR3E;HTR1E;HTR3B;HTR3A;HTR1B;HTR1A;HTR3C;HTR1D;HTR3D;HTR1F 10 0.4 4.2E-15
4 hsa04024 cAMP signaling pathway Environmental Information Processing Signal transduction HTR1E;HTR1B;HTR1A;HTR1D;HTR6;HTR1F;HTR4 7 0.2 7.2E-7
5 hsa04020 Calcium signaling pathway Environmental Information Processing Signal transduction HTR4;HTR2C;HTR2A;HTR6;HTR2B;HTR7 6 0.2 7.5E-6
6 hsa04540 Gap junction Cellular Processes Cellular community - eukaryotes HTR2A;HTR2B;HTR2C 3 0.21 0.002
7 hsa04750 Inflammatory mediator regulation of TRP channels Organismal Systems Sensory system HTR2A;HTR2B;HTR2C 3 0.28 0.0024
8 hsa04022 cGMP-PKG signaling pathway Environmental Information Processing Signal transduction ADRA2A;ADRA2B;ADRA2C 3 0.2 0.0086
9 hsa04014 Ras signaling pathway Environmental Information Processing Signal transduction HTR7 1 0.22 0.45



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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.