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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
The red circled blue spheres are used for the predicted targets.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB09244


17 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)
1 hsa04726 Serotonergic synapse Organismal Systems Nervous system MAOA;HTR1A 2 0.16 0.012
2 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction ADRA2A;HTR1A 2 0.27 0.034
3 hsa00330 Arginine and proline metabolism Metabolism Amino acid metabolism MAOA 1 0.098 0.038
4 hsa05030 Cocaine addiction Human Diseases Substance dependence MAOA 1 0.13 0.038
5 hsa00360 Phenylalanine metabolism Metabolism Amino acid metabolism MAOA 1 0.11 0.039
6 hsa00260 Glycine, serine and threonine metabolism Metabolism Amino acid metabolism MAOA 1 0.086 0.039
7 hsa00380 Tryptophan metabolism Metabolism Amino acid metabolism MAOA 1 0.086 0.039
8 hsa00340 Histidine metabolism Metabolism Amino acid metabolism MAOA 1 0.15 0.039
9 hsa05031 Amphetamine addiction Human Diseases Substance dependence MAOA 1 0.14 0.044
10 hsa00982 Drug metabolism - cytochrome P450 Metabolism Xenobiotics biodegradation and metabolism MAOA 1 0.084 0.044
11 hsa00350 Tyrosine metabolism Metabolism Amino acid metabolism MAOA 1 0.084 0.045
12 hsa04742 Taste transduction Organismal Systems Sensory system HTR1A 1 0.13 0.047
13 hsa04728 Dopaminergic synapse Organismal Systems Nervous system MAOA 1 0.15 0.068
14 hsa04022 cGMP-PKG signaling pathway Environmental Information Processing Signal transduction ADRA2A 1 0.15 0.078
15 hsa05034 Alcoholism Human Diseases Substance dependence MAOA 1 0.14 0.08
16 hsa04024 cAMP signaling pathway Environmental Information Processing Signal transduction HTR1A 1 0.2 0.082
17 hsa01100 Metabolic pathways Metabolism Global and overview maps MAOA 1 0.27 0.43


14 pathways for predicted targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)
1 hsa04020 Calcium signaling pathway Environmental Information Processing Signal transduction HTR2C;ADRA1A;DRD5;ADRA1B;ADRB3;DRD1;HTR2A;ADRA1D;HTR2B;HTR7 10 0.18 6.5E-11
2 hsa04540 Gap junction Cellular Processes Cellular community - eukaryotes DRD1;DRD2;HTR2A;HTR2B;HTR2C 5 0.12 1.4E-5
3 hsa04970 Salivary secretion Organismal Systems Digestive system ADRA1A;ADRA1B;ADRB3;ADRA1D 4 0.16 0.00031
4 hsa04750 Inflammatory mediator regulation of TRP channels Organismal Systems Sensory system HTR2A;HTR2B;HTR2C 3 0.13 0.0066
5 hsa04270 Vascular smooth muscle contraction Organismal Systems Circulatory system ADRA1A;ADRA1B;ADRA1D 3 0.14 0.0093
6 hsa04261 Adrenergic signaling in cardiomyocytes Organismal Systems Circulatory system ADRA1A;ADRA1B;ADRA1D 3 0.11 0.011
7 hsa05012 Parkinson disease Human Diseases Neurodegenerative diseases DRD1;DRD2;SLC6A3 3 0.24 0.011
8 hsa04923 Regulation of lipolysis in adipocytes Organismal Systems Endocrine system ADRB3 1 0.19 0.23
9 hsa04924 Renin secretion Organismal Systems Endocrine system ADRB3 1 0.2 0.24
10 hsa05032 Morphine addiction Human Diseases Substance dependence DRD1 1 0.14 0.29
11 hsa04152 AMPK signaling pathway Environmental Information Processing Signal transduction ADRA1A 1 0.31 0.34
12 hsa04714 Thermogenesis Organismal Systems Environmental adaptation ADRB3 1 0.47 0.45
13 hsa04014 Ras signaling pathway Environmental Information Processing Signal transduction HTR7 1 0.12 0.45
14 hsa04015 Rap1 signaling pathway Environmental Information Processing Signal transduction DRD2 1 0.11 0.48



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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.