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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB11273


17 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)
1 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction HTR6;ADRA2A;HTR4;ADRA2C;ADRB2;ADRA1B;ADRB3;HTR1A;ADRB1;HTR1B;HTR1D;HTR2C;HTR2A;ADRA1A;HTR1F;HTR7;ADRA1D;ADRA2B;HTR2B;HTR1E 20 0.27 9.4E-24
2 hsa04726 Serotonergic synapse Organismal Systems Nervous system HTR3E;HTR3D;HTR4;HTR3B;HTR3A;HTR1B;HTR1A;HTR3C;HTR1D;HTR2C;HTR2A;HTR6;HTR1F;HTR7;HTR2B;HTR1E 16 0.16 5.3E-23
3 hsa04742 Taste transduction Organismal Systems Sensory system HTR3E;HTR1E;HTR3B;HTR3A;HTR1B;HTR1A;HTR3C;HTR1D;HTR3D;HTR1F 10 0.19 2.7E-13
4 hsa04020 Calcium signaling pathway Environmental Information Processing Signal transduction HTR4;ADRA1A;ADRB2;ADRA1B;ADRB3;ADRB1;HTR2A;HTR6;HTR7;ADRA1D;HTR2B;HTR2C 12 0.19 5.5E-13
5 hsa04022 cGMP-PKG signaling pathway Environmental Information Processing Signal transduction ADRA2A;ADRA1A;ADRB2;ADRA1B;ADRB3;ADRB1;ADRA2B;ADRA1D;ADRA2C 9 0.15 4.6E-9
6 hsa04024 cAMP signaling pathway Environmental Information Processing Signal transduction HTR1E;HTR1B;ADRB2;HTR1A;ADRB1;HTR1D;HTR6;HTR1F;HTR4 9 0.19 2.2E-8
7 hsa04970 Salivary secretion Organismal Systems Digestive system ADRA1A;ADRB2;ADRA1B;ADRB3;ADRB1;ADRA1D 6 0.17 9.3E-7
8 hsa04261 Adrenergic signaling in cardiomyocytes Organismal Systems Circulatory system ADRB1;ADRA1A;ADRB2;ADRA1B;ADRA1D 5 0.14 0.00021
9 hsa04540 Gap junction Cellular Processes Cellular community - eukaryotes ADRB1;HTR2A;HTR2B;HTR2C 4 0.14 0.00036
10 hsa04923 Regulation of lipolysis in adipocytes Organismal Systems Endocrine system ADRB1;ADRB2;ADRB3 3 0.22 0.0012
11 hsa04924 Renin secretion Organismal Systems Endocrine system ADRB1;ADRB2;ADRB3 3 0.24 0.0019
12 hsa04750 Inflammatory mediator regulation of TRP channels Organismal Systems Sensory system HTR2A;HTR2B;HTR2C 3 0.16 0.006
13 hsa04270 Vascular smooth muscle contraction Organismal Systems Circulatory system ADRA1A;ADRA1B;ADRA1D 3 0.17 0.0096
14 hsa05414 Dilated cardiomyopathy (DCM) Human Diseases Cardiovascular diseases ADRB1 1 0.52 0.32
15 hsa04152 AMPK signaling pathway Environmental Information Processing Signal transduction ADRA1A 1 0.29 0.38
16 hsa04714 Thermogenesis Organismal Systems Environmental adaptation ADRB3 1 0.38 0.55
17 hsa04014 Ras signaling pathway Environmental Information Processing Signal transduction HTR7 1 0.15 0.55



  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

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The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.