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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB01577


17 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)
1 hsa05030 Cocaine addiction Human Diseases Substance dependence MAOB;SLC18A2;MAOA;SLC6A3;SLC18A1 5 0.12 4.1E-8
2 hsa05031 Amphetamine addiction Human Diseases Substance dependence MAOB;SLC18A2;MAOA;SLC6A3;SLC18A1 5 0.12 1.1E-7
3 hsa04726 Serotonergic synapse Organismal Systems Nervous system SLC6A4;MAOB;SLC18A2;MAOA;SLC18A1 5 0.15 1.1E-6
4 hsa04728 Dopaminergic synapse Organismal Systems Nervous system MAOB;SLC18A2;MAOA;SLC6A3;SLC18A1 5 0.14 1.5E-6
5 hsa05034 Alcoholism Human Diseases Substance dependence MAOB;SLC18A2;MAOA;SLC6A3;SLC18A1 5 0.12 6.0E-6
6 hsa00360 Phenylalanine metabolism Metabolism Amino acid metabolism MAOB;MAOA 2 0.083 0.00061
7 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction ADRA2A;TAAR1;ADRA2B;ADRA2C 4 0.27 0.00079
8 hsa00340 Histidine metabolism Metabolism Amino acid metabolism MAOB;MAOA 2 0.097 0.00085
9 hsa05012 Parkinson disease Human Diseases Neurodegenerative diseases SLC18A2;SLC6A3;SLC18A1 3 0.12 0.0014
10 hsa00260 Glycine, serine and threonine metabolism Metabolism Amino acid metabolism MAOB;MAOA 2 0.069 0.0016
11 hsa00380 Tryptophan metabolism Metabolism Amino acid metabolism MAOB;MAOA 2 0.069 0.0016
12 hsa00350 Tyrosine metabolism Metabolism Amino acid metabolism MAOB;MAOA 2 0.072 0.0017
13 hsa04022 cGMP-PKG signaling pathway Environmental Information Processing Signal transduction ADRA2A;ADRA2B;ADRA2C 3 0.14 0.0017
14 hsa00330 Arginine and proline metabolism Metabolism Amino acid metabolism MAOB;MAOA 2 0.085 0.0023
15 hsa04721 Synaptic vesicle cycle Organismal Systems Nervous system SLC18A2;SLC18A1 2 0.12 0.0034
16 hsa00982 Drug metabolism - cytochrome P450 Metabolism Xenobiotics biodegradation and metabolism MAOB;MAOA 2 0.072 0.0042
17 hsa01100 Metabolic pathways Metabolism Global and overview maps MAOB;MAOA 2 0.27 0.54



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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.