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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
The red circled blue spheres are used for the predicted targets.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB01363


26 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)
1 hsa05030 Cocaine addiction Human Diseases Substance dependence MAOB;SLC18A2;MAOA;SLC6A3;SLC18A1 5 0.13 2.0E-7
2 hsa05031 Amphetamine addiction Human Diseases Substance dependence MAOB;SLC18A2;MAOA;SLC6A3;SLC18A1 5 0.13 5.3E-7
3 hsa04022 cGMP-PKG signaling pathway Environmental Information Processing Signal transduction ADRA2A;ADRA2C;ADRB2;ADRB3;ADRB1;ADRA2B 6 0.14 7.1E-7
4 hsa04726 Serotonergic synapse Organismal Systems Nervous system SLC6A4;MAOB;SLC18A2;MAOA;SLC18A1 5 0.16 3.7E-6
5 hsa04728 Dopaminergic synapse Organismal Systems Nervous system MAOB;SLC18A2;MAOA;SLC6A3;SLC18A1 5 0.14 5.7E-6
6 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction ADRA2A;ADRA2C;ADRB2;ADRB3;ADRB1;ADRA2B 6 0.27 8.2E-6
7 hsa05034 Alcoholism Human Diseases Substance dependence MAOB;SLC18A2;MAOA;SLC6A3;SLC18A1 5 0.13 2.0E-5
8 hsa04923 Regulation of lipolysis in adipocytes Organismal Systems Endocrine system ADRB1;ADRB2;ADRB3 3 0.13 0.00024
9 hsa04924 Renin secretion Organismal Systems Endocrine system ADRB1;ADRB2;ADRB3 3 0.14 0.00038
10 hsa04970 Salivary secretion Organismal Systems Digestive system ADRB1;ADRB2;ADRB3 3 0.13 0.00081
11 hsa00360 Phenylalanine metabolism Metabolism Amino acid metabolism MAOB;MAOA 2 0.13 0.00081
12 hsa00340 Histidine metabolism Metabolism Amino acid metabolism MAOB;MAOA 2 0.15 0.0013
13 hsa05012 Parkinson disease Human Diseases Neurodegenerative diseases SLC18A2;SLC6A3;SLC18A1 3 0.15 0.0026
14 hsa00350 Tyrosine metabolism Metabolism Amino acid metabolism MAOB;MAOA 2 0.11 0.0027
15 hsa00260 Glycine, serine and threonine metabolism Metabolism Amino acid metabolism MAOB;MAOA 2 0.11 0.0029
16 hsa00380 Tryptophan metabolism Metabolism Amino acid metabolism MAOB;MAOA 2 0.11 0.0029
17 hsa04020 Calcium signaling pathway Environmental Information Processing Signal transduction ADRB1;ADRB2;ADRB3 3 0.2 0.004
18 hsa00330 Arginine and proline metabolism Metabolism Amino acid metabolism MAOB;MAOA 2 0.13 0.004
19 hsa04721 Synaptic vesicle cycle Organismal Systems Nervous system SLC18A2;SLC18A1 2 0.18 0.006
20 hsa00982 Drug metabolism - cytochrome P450 Metabolism Xenobiotics biodegradation and metabolism MAOB;MAOA 2 0.11 0.0074
21 hsa04261 Adrenergic signaling in cardiomyocytes Organismal Systems Circulatory system ADRB1;ADRB2 2 0.14 0.027
22 hsa04024 cAMP signaling pathway Environmental Information Processing Signal transduction ADRB1;ADRB2 2 0.2 0.046
23 hsa04540 Gap junction Cellular Processes Cellular community - eukaryotes ADRB1 1 0.14 0.15
24 hsa05414 Dilated cardiomyopathy (DCM) Human Diseases Cardiovascular diseases ADRB1 1 0.14 0.15
25 hsa04714 Thermogenesis Organismal Systems Environmental adaptation ADRB3 1 0.16 0.32
26 hsa01100 Metabolic pathways Metabolism Global and overview maps MAOB;MAOA 2 0.27 0.64


7 pathways for predicted targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)
1 hsa04742 Taste transduction Organismal Systems Sensory system HTR3A;HTR1B;HTR1A;HTR1D;HTR3B 5 0.19 1.4E-5
2 hsa04750 Inflammatory mediator regulation of TRP channels Organismal Systems Sensory system HRH1;HTR2A;HTR2B;HTR2C 4 0.11 0.00042
3 hsa04270 Vascular smooth muscle contraction Organismal Systems Circulatory system ADRA1A;ADRA1B;ADRA1D 3 0.14 0.009
4 hsa05032 Morphine addiction Human Diseases Substance dependence DRD1 1 0.13 0.38
5 hsa04152 AMPK signaling pathway Environmental Information Processing Signal transduction ADRA1A 1 0.28 0.39
6 hsa04014 Ras signaling pathway Environmental Information Processing Signal transduction HTR7 1 0.11 0.47
7 hsa04015 Rap1 signaling pathway Environmental Information Processing Signal transduction DRD2 1 0.11 0.47



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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.