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Network of pathways (lightgreen rectangle) and targets (blue spheres) for the queried drug is displayed above.
Selecting nodes by clicking will fade out the nodes which are not connected to the selected nodes.

Data source: DrugBank-all; Query type: chemical-target; # of predictions: 20; Secondary interactions: yes
Input drug 1: Loxapine
Input target 1: ADA2A


29 pathways for known targets of input drug:
No. Pathway ID Pathway name Pathway Class 1 Pathway Class 2 Targets # of targets p-value (EPD) p-value (EPT)
1 hsa04080 Neuroactive ligand-receptor interaction Environmental Information Processing Signaling molecules and interaction ADRA2A;HTR1E;DRD2;ADRA1B;ADRB1;DRD4;CHRM5;ADRA1A;ADRA2B;HTR2C;CHRM3;HRH1;DRD3;HTR7;HTR2A;CHRM2;HTR5A;DRD5;CHRM4;HRH4;CHRM1;HTR1D;HTR6;HRH2;ADRA2C;HTR1A;DRD1;HTR1B 28 0.27 2.6E-36
2 hsa04020 Calcium signaling pathway Environmental Information Processing Signal transduction CHRM5;HTR2C;CHRM2;ADRA1A;DRD5;ADRA1B;HTR5A;ADRB1;DRD1;CHRM1;HTR2A;HRH2;CHRM3;HTR6;HRH1;HTR7 16 0.19 2.8E-17
3 hsa04726 Serotonergic synapse Organismal Systems Nervous system SLC6A4;HTR2A;HTR1D;HTR3A;HTR1B;HTR1A;HTR1E;HTR2C;HTR5A;HTR6;HTR7 11 0.15 4.5E-12
4 hsa04024 cAMP signaling pathway Environmental Information Processing Signal transduction CHRM2;HTR1E;HTR1B;DRD5;HTR1A;ADRB1;DRD1;CHRM1;HTR1D;HTR6;DRD2 11 0.19 1.3E-9
5 hsa04742 Taste transduction Organismal Systems Sensory system HTR1E;HTR3A;HTR1B;HTR1A;HTR1D;CHRM3 6 0.21 5.4E-6
6 hsa04728 Dopaminergic synapse Organismal Systems Nervous system DRD5;DRD1;DRD3;DRD4;DRD2;SLC6A3 6 0.14 6.4E-5
7 hsa04540 Gap junction Cellular Processes Cellular community - eukaryotes ADRB1;DRD1;HTR2C;HTR2A;DRD2 5 0.14 0.00011
8 hsa04022 cGMP-PKG signaling pathway Environmental Information Processing Signal transduction ADRA2A;ADRA1A;ADRA1B;ADRB1;ADRA2B;ADRA2C 6 0.14 0.00017
9 hsa04725 Cholinergic synapse Organismal Systems Nervous system CHRM3;CHRM2;CHRM4;CHRM1;CHRM5 5 0.15 0.00028
10 hsa04970 Salivary secretion Organismal Systems Digestive system ADRB1;CHRM3;ADRA1B;ADRA1A 4 0.2 0.0014
11 hsa05030 Cocaine addiction Human Diseases Substance dependence DRD1;DRD2;SLC6A3 3 0.23 0.0028
12 hsa04810 Regulation of actin cytoskeleton Cellular Processes Cell motility CHRM3;CHRM2;CHRM4;CHRM1;CHRM5 5 0.14 0.004
13 hsa04750 Inflammatory mediator regulation of TRP channels Organismal Systems Sensory system HRH1;HTR2C;HTR2A 3 0.15 0.017
14 hsa05012 Parkinson disease Human Diseases Neurodegenerative diseases DRD1;DRD2;SLC6A3 3 0.39 0.041
15 hsa04261 Adrenergic signaling in cardiomyocytes Organismal Systems Circulatory system ADRB1;ADRA1A;ADRA1B 3 0.14 0.041
16 hsa05031 Amphetamine addiction Human Diseases Substance dependence DRD1;SLC6A3 2 0.24 0.058
17 hsa05034 Alcoholism Human Diseases Substance dependence DRD1;DRD2;SLC6A3 3 0.17 0.062
18 hsa04971 Gastric acid secretion Organismal Systems Digestive system CHRM3;HRH2 2 0.48 0.062
19 hsa04270 Vascular smooth muscle contraction Organismal Systems Circulatory system ADRA1A;ADRA1B 2 0.18 0.14
20 hsa04923 Regulation of lipolysis in adipocytes Organismal Systems Endocrine system ADRB1 1 0.26 0.29
21 hsa04924 Renin secretion Organismal Systems Endocrine system ADRB1 1 0.29 0.33
22 hsa05414 Dilated cardiomyopathy (DCM) Human Diseases Cardiovascular diseases ADRB1 1 0.74 0.38
23 hsa05032 Morphine addiction Human Diseases Substance dependence DRD1 1 0.18 0.38
24 hsa04972 Pancreatic secretion Organismal Systems Digestive system CHRM3 1 0.16 0.38
25 hsa04911 Insulin secretion Organismal Systems Endocrine system CHRM3 1 0.59 0.39
26 hsa04152 AMPK signaling pathway Environmental Information Processing Signal transduction ADRA1A 1 0.33 0.44
27 hsa04151 PI3K-Akt signaling pathway Environmental Information Processing Signal transduction CHRM2;CHRM1 2 0.19 0.47
28 hsa04015 Rap1 signaling pathway Environmental Information Processing Signal transduction DRD2 1 0.14 0.6
29 hsa04014 Ras signaling pathway Environmental Information Processing Signal transduction HTR7 1 0.15 0.62



  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.