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GO enrichment results  
   
Top 20 enriched GO molecular function (p-value based on targets)

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Data source: DrugBank-all; Query type: chemical; # of predictions: 20; Secondary interactions: no
Input drug 1: DB00800


17 GO molecular function of known targets for input drug:
No. GO terms Targets # of targets p-value (EPT)↑ p-value (EPD)
1 alpha1-adrenergic receptor activity ADRA1A;ADRA1B;ADRA1D 3 1.3E-7 0.042
2 alpha2-adrenergic receptor activity ADRA2A;ADRA2B;ADRA2C 3 1.3E-7 0.048
3 epinephrine binding ADRA2A;ADRA2B;ADRA2C 3 1.7E-6 0.054
4 dopamine neurotransmitter receptor activity, coupled via Gs DRD1;DRD5 2 3.0E-5 0.11
5 dopamine neurotransmitter receptor activity DRD1;DRD5 2 7.2E-5 0.093
6 protein heterodimerization activity ADRA2A;ADRA1B;ADRA1A;ADRA2C 4 8.6E-5 0.1
7 G-protein coupled amine receptor activity DRD1;DRD5 2 0.0001 0.073
8 dopamine binding DRD1;DRD5 2 0.00042 0.064
9 heterotrimeric G-protein binding ADRA2A 1 0.0048 0.058
10 alpha-1B adrenergic receptor binding ADRA2A 1 0.0048 0.05
11 alpha-2C adrenergic receptor binding ADRA2A 1 0.0088 0.05
12 norepinephrine binding ADRA2A 1 0.016 0.054
13 alpha-2A adrenergic receptor binding ADRA2C 1 0.017 0.042
14 thioesterase binding ADRA2A 1 0.017 0.044
15 protein homodimerization activity ADRA2A;ADRA2C 2 0.11 0.17
16 drug binding DRD1 1 0.18 0.19
17 protein kinase binding ADRA2A 1 0.23 0.097


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

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The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.